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Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Wei J, Xiong XF, Lin YH, Zheng BX, Cheng DY - PeerJ (2015)

Bottom Line: Results.Conclusions.No evidence showing positive or negative association between IL-6 concentrations and the severity of pulmonary function impairment was found.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University , Chengdu, Sichuan , China.

ABSTRACT
Background. Interleukin-6 (IL-6) is an important pro-inflammatory cytokine and has been implicated to play a role in the systemic inflammation of patients with chronic obstructive pulmonary disease (COPD). We conducted this meta-analysis to assess the association between serum IL-6 concentrations and COPD. Methods. PubMed and Embase were searched for eligible studies. Data were extracted by two investigators (Wei J, Xiong XF) independently and analyzed using Review Manager 5.3 and STATA 12.0 software. Standard mean differences (SMDs) and 95% confidence intervals (CI) were calculated. Results. Thirty-three studies were included in this meta-analysis. The serum IL-6 concentrations were higher in patients with stable COPD than healthy controls (SMD = 0.65, 95% CI [0.51-0.79]). COPD patients without major comorbidities also showed higher IL-6 levels than healthy controls (SMD = 0.74, 95% CI [0.56-0.91]). COPD patients with an forced expiratory volume in one second (FEV1) of either <50% predicted or >50% predicted had increased IL-6 concentrations compared to healthy controls (SMD = 0.77, 95% CI [0.48-1.05], SMD = 1.01, 95% CI [0.43-1.59], respectively). The serum IL-6 concentrations between mild-moderate and severe-very severe COPD patient groups were not found to be significant (SMD = -0.1, 95% CI [-0.65-0.44]). Conclusions. This meta-analysis indicated that patients with stable COPD had higher serum IL-6 concentrations than healthy controls. No evidence showing positive or negative association between IL-6 concentrations and the severity of pulmonary function impairment was found. The correlation between IL-6 levels and pulmonary function was weak in different severities of stable COPD patients.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of study indentification, inclusion and exclusion.
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fig-1: Flow diagram of study indentification, inclusion and exclusion.

Mentions: We identified 537 relevant studies that fit our search strategy. The procedure for identifying and selecting eligible studies is shown in Fig. 1. Of all the potential studies, 19 duplicate records were removed, leaving 518 articles for screening. 426 articles were excluded by screening titles and abstracts. Two articles were not accessible and only 90 were available for full-text reading. After reading the full text, 26 articles were excluded according to the exclusion criteria. Among the 64 articles, another 30 were excluded as the data were presented as median (range) and were not suitable for meta-analysis. One study had a standard differential with zero, so the data was excluded. Finally, a total of 33 articles were included for our systematic review and meta-analysis (Aaron et al., 2010; Bai et al., 2011; Bolton et al., 2007a; Bolton et al., 2007b; de Moraes et al., 2014; Debigare et al., 2003; Foschino Barbaro et al., 2007; Gagnon et al., 2014; Gale et al., 2011; Hacker et al., 2009; Hageman et al., 2003; He et al., 2010; Higashimoto et al., 2008; Huertas et al., 2010; Itoh et al., 2004; Jammes et al., 2008; Ju & Chen, 2012; Karadag et al., 2008a; Karadag et al., 2008b; Koechlin et al., 2004; Oncel et al., 2010; Palange et al., 2006; Rabinovich et al., 2003; Sabit et al., 2007; Tomoda et al., 2007; Uzum et al., 2014; Van Helvoort et al., 2006; Vogiatzis et al., 2007; Walter et al., 2008; Wang et al., 2014; Yasuda et al., 1998; Yende et al., 2006; Ying et al., 2008). The basic characteristics of all the included studies are listed in Table 1.


Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Wei J, Xiong XF, Lin YH, Zheng BX, Cheng DY - PeerJ (2015)

Flow diagram of study indentification, inclusion and exclusion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556145&req=5

fig-1: Flow diagram of study indentification, inclusion and exclusion.
Mentions: We identified 537 relevant studies that fit our search strategy. The procedure for identifying and selecting eligible studies is shown in Fig. 1. Of all the potential studies, 19 duplicate records were removed, leaving 518 articles for screening. 426 articles were excluded by screening titles and abstracts. Two articles were not accessible and only 90 were available for full-text reading. After reading the full text, 26 articles were excluded according to the exclusion criteria. Among the 64 articles, another 30 were excluded as the data were presented as median (range) and were not suitable for meta-analysis. One study had a standard differential with zero, so the data was excluded. Finally, a total of 33 articles were included for our systematic review and meta-analysis (Aaron et al., 2010; Bai et al., 2011; Bolton et al., 2007a; Bolton et al., 2007b; de Moraes et al., 2014; Debigare et al., 2003; Foschino Barbaro et al., 2007; Gagnon et al., 2014; Gale et al., 2011; Hacker et al., 2009; Hageman et al., 2003; He et al., 2010; Higashimoto et al., 2008; Huertas et al., 2010; Itoh et al., 2004; Jammes et al., 2008; Ju & Chen, 2012; Karadag et al., 2008a; Karadag et al., 2008b; Koechlin et al., 2004; Oncel et al., 2010; Palange et al., 2006; Rabinovich et al., 2003; Sabit et al., 2007; Tomoda et al., 2007; Uzum et al., 2014; Van Helvoort et al., 2006; Vogiatzis et al., 2007; Walter et al., 2008; Wang et al., 2014; Yasuda et al., 1998; Yende et al., 2006; Ying et al., 2008). The basic characteristics of all the included studies are listed in Table 1.

Bottom Line: Results.Conclusions.No evidence showing positive or negative association between IL-6 concentrations and the severity of pulmonary function impairment was found.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University , Chengdu, Sichuan , China.

ABSTRACT
Background. Interleukin-6 (IL-6) is an important pro-inflammatory cytokine and has been implicated to play a role in the systemic inflammation of patients with chronic obstructive pulmonary disease (COPD). We conducted this meta-analysis to assess the association between serum IL-6 concentrations and COPD. Methods. PubMed and Embase were searched for eligible studies. Data were extracted by two investigators (Wei J, Xiong XF) independently and analyzed using Review Manager 5.3 and STATA 12.0 software. Standard mean differences (SMDs) and 95% confidence intervals (CI) were calculated. Results. Thirty-three studies were included in this meta-analysis. The serum IL-6 concentrations were higher in patients with stable COPD than healthy controls (SMD = 0.65, 95% CI [0.51-0.79]). COPD patients without major comorbidities also showed higher IL-6 levels than healthy controls (SMD = 0.74, 95% CI [0.56-0.91]). COPD patients with an forced expiratory volume in one second (FEV1) of either <50% predicted or >50% predicted had increased IL-6 concentrations compared to healthy controls (SMD = 0.77, 95% CI [0.48-1.05], SMD = 1.01, 95% CI [0.43-1.59], respectively). The serum IL-6 concentrations between mild-moderate and severe-very severe COPD patient groups were not found to be significant (SMD = -0.1, 95% CI [-0.65-0.44]). Conclusions. This meta-analysis indicated that patients with stable COPD had higher serum IL-6 concentrations than healthy controls. No evidence showing positive or negative association between IL-6 concentrations and the severity of pulmonary function impairment was found. The correlation between IL-6 levels and pulmonary function was weak in different severities of stable COPD patients.

No MeSH data available.


Related in: MedlinePlus