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Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera.

Akeo K, Kameya S, Gocho K, Kubota D, Yamaki K, Takahashi H - Case Rep Ophthalmol Med (2015)

Bottom Line: A reported RS1 gene mutation was found (P203L) in the patient.Conclusions.However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba 270-1694, Japan.

ABSTRACT
Purpose. To report the morphological and functional changes associated with a regression of foveoschisis in a patient with X-linked retinoschisis (XLRS). Methods. A 42-year-old man with XLRS underwent genetic analysis and detailed ophthalmic examinations. Functional assessments included best-corrected visual acuity (BCVA), full-field electroretinograms (ERGs), and multifocal ERGs (mfERGs). Morphological assessments included fundus photography, spectral-domain optical coherence tomography (SD-OCT), and adaptive optics (AO) fundus imaging. After the baseline clinical data were obtained, topical dorzolamide was applied to the patient. The patient was followed for 24 months. Results. A reported RS1 gene mutation was found (P203L) in the patient. At the baseline, his decimal BCVA was 0.15 in the right and 0.3 in the left eye. Fundus photographs showed bilateral spoke wheel-appearing maculopathy. SD-OCT confirmed the foveoschisis in the left eye. The AO images of the left eye showed spoke wheel retinal folds, and the folds were thinner than those in fundus photographs. During the follow-up period, the foveal thickness in the SD-OCT images and the number of retinal folds in the AO images were reduced. Conclusions. We have presented the detailed morphological changes of foveoschisis in a patient with XLRS detected by SD-OCT and AO fundus camera. However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

No MeSH data available.


Related in: MedlinePlus

Time course of AO images and images (a, c, e) with highlighted retinal folds (b, d, f). (a) and (b) Baseline AO image (a) and image with highlighted retinal folds (b) of the left eye are shown. Spoke wheel pattern of retinal folds is highlighted by yellow line in (b). Red circle indicates 500 μm circle from the fixation point. (c) and (d) AO image of the same eye after 4 months of treatment with dorzolamide is shown. (e) and (f) AO image of the same eye after 20 months of treatment with dorzolamide is shown. Bar 200 μm.
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fig6: Time course of AO images and images (a, c, e) with highlighted retinal folds (b, d, f). (a) and (b) Baseline AO image (a) and image with highlighted retinal folds (b) of the left eye are shown. Spoke wheel pattern of retinal folds is highlighted by yellow line in (b). Red circle indicates 500 μm circle from the fixation point. (c) and (d) AO image of the same eye after 4 months of treatment with dorzolamide is shown. (e) and (f) AO image of the same eye after 20 months of treatment with dorzolamide is shown. Bar 200 μm.

Mentions: Morphologically, cystoid macular edema in his left fundus became undetectable at the center of the fovea in 14 months from the baseline. The time course of the SD-OCT images showed a reduction of the retinal fluid and the foveal thickness in the left eye (Figure 4, Table 1). The number of the retinal folds in the AO images of his left eye was fewer than that at the baseline during the follow-up period (Figure 6, Table 1).


Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera.

Akeo K, Kameya S, Gocho K, Kubota D, Yamaki K, Takahashi H - Case Rep Ophthalmol Med (2015)

Time course of AO images and images (a, c, e) with highlighted retinal folds (b, d, f). (a) and (b) Baseline AO image (a) and image with highlighted retinal folds (b) of the left eye are shown. Spoke wheel pattern of retinal folds is highlighted by yellow line in (b). Red circle indicates 500 μm circle from the fixation point. (c) and (d) AO image of the same eye after 4 months of treatment with dorzolamide is shown. (e) and (f) AO image of the same eye after 20 months of treatment with dorzolamide is shown. Bar 200 μm.
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Related In: Results  -  Collection

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fig6: Time course of AO images and images (a, c, e) with highlighted retinal folds (b, d, f). (a) and (b) Baseline AO image (a) and image with highlighted retinal folds (b) of the left eye are shown. Spoke wheel pattern of retinal folds is highlighted by yellow line in (b). Red circle indicates 500 μm circle from the fixation point. (c) and (d) AO image of the same eye after 4 months of treatment with dorzolamide is shown. (e) and (f) AO image of the same eye after 20 months of treatment with dorzolamide is shown. Bar 200 μm.
Mentions: Morphologically, cystoid macular edema in his left fundus became undetectable at the center of the fovea in 14 months from the baseline. The time course of the SD-OCT images showed a reduction of the retinal fluid and the foveal thickness in the left eye (Figure 4, Table 1). The number of the retinal folds in the AO images of his left eye was fewer than that at the baseline during the follow-up period (Figure 6, Table 1).

Bottom Line: A reported RS1 gene mutation was found (P203L) in the patient.Conclusions.However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba 270-1694, Japan.

ABSTRACT
Purpose. To report the morphological and functional changes associated with a regression of foveoschisis in a patient with X-linked retinoschisis (XLRS). Methods. A 42-year-old man with XLRS underwent genetic analysis and detailed ophthalmic examinations. Functional assessments included best-corrected visual acuity (BCVA), full-field electroretinograms (ERGs), and multifocal ERGs (mfERGs). Morphological assessments included fundus photography, spectral-domain optical coherence tomography (SD-OCT), and adaptive optics (AO) fundus imaging. After the baseline clinical data were obtained, topical dorzolamide was applied to the patient. The patient was followed for 24 months. Results. A reported RS1 gene mutation was found (P203L) in the patient. At the baseline, his decimal BCVA was 0.15 in the right and 0.3 in the left eye. Fundus photographs showed bilateral spoke wheel-appearing maculopathy. SD-OCT confirmed the foveoschisis in the left eye. The AO images of the left eye showed spoke wheel retinal folds, and the folds were thinner than those in fundus photographs. During the follow-up period, the foveal thickness in the SD-OCT images and the number of retinal folds in the AO images were reduced. Conclusions. We have presented the detailed morphological changes of foveoschisis in a patient with XLRS detected by SD-OCT and AO fundus camera. However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

No MeSH data available.


Related in: MedlinePlus