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Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera.

Akeo K, Kameya S, Gocho K, Kubota D, Yamaki K, Takahashi H - Case Rep Ophthalmol Med (2015)

Bottom Line: A reported RS1 gene mutation was found (P203L) in the patient.Conclusions.However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba 270-1694, Japan.

ABSTRACT
Purpose. To report the morphological and functional changes associated with a regression of foveoschisis in a patient with X-linked retinoschisis (XLRS). Methods. A 42-year-old man with XLRS underwent genetic analysis and detailed ophthalmic examinations. Functional assessments included best-corrected visual acuity (BCVA), full-field electroretinograms (ERGs), and multifocal ERGs (mfERGs). Morphological assessments included fundus photography, spectral-domain optical coherence tomography (SD-OCT), and adaptive optics (AO) fundus imaging. After the baseline clinical data were obtained, topical dorzolamide was applied to the patient. The patient was followed for 24 months. Results. A reported RS1 gene mutation was found (P203L) in the patient. At the baseline, his decimal BCVA was 0.15 in the right and 0.3 in the left eye. Fundus photographs showed bilateral spoke wheel-appearing maculopathy. SD-OCT confirmed the foveoschisis in the left eye. The AO images of the left eye showed spoke wheel retinal folds, and the folds were thinner than those in fundus photographs. During the follow-up period, the foveal thickness in the SD-OCT images and the number of retinal folds in the AO images were reduced. Conclusions. We have presented the detailed morphological changes of foveoschisis in a patient with XLRS detected by SD-OCT and AO fundus camera. However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

No MeSH data available.


Related in: MedlinePlus

Fundus photographs and fundus autofluorescence (FAF) images of a patient with X-linked retinoschisis (XLRS). Fundus photographs show spoke wheel-like maculopathy in the left eye and central atrophy in the right eye. The FAF images show hypofluorescent areas in both maculas.
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fig3: Fundus photographs and fundus autofluorescence (FAF) images of a patient with X-linked retinoschisis (XLRS). Fundus photographs show spoke wheel-like maculopathy in the left eye and central atrophy in the right eye. The FAF images show hypofluorescent areas in both maculas.

Mentions: Fundus examination showed spoke wheel-like maculopathy in the left eye and central atrophy in the right eye (Figure 3). The mean width of radial white lines in the spoke wheel pattern in the fundus photographs was 109 ± 21 μm at 500 μm from the foveal center in his left eye. Peripheral retinoschisis was not observed in both eyes. FAF imaging showed a hypofluorescent lesion in the macula of both eyes (Figure 3). The SD-OCT images showed a thinning of the total retinal thickness in right eye and foveoschisis mainly at the inner nuclear layer of the left eye. The ellipsoid and interdigitation zones were not detected in the fovea of the SD-OCT images of both eyes. The structure of inner nuclear layer, inner plexiform layer, and ganglion cell layer in the right eye was relatively preserved (Figure 4). Examination of a montage of the AO images of the left eye showed a spoke wheel pattern of retinal folds which had a thin inner retinal cavity possibly caused by the foveoschisis in the inner retinal layer (Figure 5). These folds were not present in the right eye (Figure 5). The width of spoke wheel retinal folds in the AO image in the left eye was thinner than that in the fundus photographs (Figures 3 and 5, Table 1). The cone mosaic was not clearly resolved throughout the retinal region, in which the ellipsoid and interdigitation zones were undetectable in SD-OCT images.


Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera.

Akeo K, Kameya S, Gocho K, Kubota D, Yamaki K, Takahashi H - Case Rep Ophthalmol Med (2015)

Fundus photographs and fundus autofluorescence (FAF) images of a patient with X-linked retinoschisis (XLRS). Fundus photographs show spoke wheel-like maculopathy in the left eye and central atrophy in the right eye. The FAF images show hypofluorescent areas in both maculas.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4556076&req=5

fig3: Fundus photographs and fundus autofluorescence (FAF) images of a patient with X-linked retinoschisis (XLRS). Fundus photographs show spoke wheel-like maculopathy in the left eye and central atrophy in the right eye. The FAF images show hypofluorescent areas in both maculas.
Mentions: Fundus examination showed spoke wheel-like maculopathy in the left eye and central atrophy in the right eye (Figure 3). The mean width of radial white lines in the spoke wheel pattern in the fundus photographs was 109 ± 21 μm at 500 μm from the foveal center in his left eye. Peripheral retinoschisis was not observed in both eyes. FAF imaging showed a hypofluorescent lesion in the macula of both eyes (Figure 3). The SD-OCT images showed a thinning of the total retinal thickness in right eye and foveoschisis mainly at the inner nuclear layer of the left eye. The ellipsoid and interdigitation zones were not detected in the fovea of the SD-OCT images of both eyes. The structure of inner nuclear layer, inner plexiform layer, and ganglion cell layer in the right eye was relatively preserved (Figure 4). Examination of a montage of the AO images of the left eye showed a spoke wheel pattern of retinal folds which had a thin inner retinal cavity possibly caused by the foveoschisis in the inner retinal layer (Figure 5). These folds were not present in the right eye (Figure 5). The width of spoke wheel retinal folds in the AO image in the left eye was thinner than that in the fundus photographs (Figures 3 and 5, Table 1). The cone mosaic was not clearly resolved throughout the retinal region, in which the ellipsoid and interdigitation zones were undetectable in SD-OCT images.

Bottom Line: A reported RS1 gene mutation was found (P203L) in the patient.Conclusions.However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba 270-1694, Japan.

ABSTRACT
Purpose. To report the morphological and functional changes associated with a regression of foveoschisis in a patient with X-linked retinoschisis (XLRS). Methods. A 42-year-old man with XLRS underwent genetic analysis and detailed ophthalmic examinations. Functional assessments included best-corrected visual acuity (BCVA), full-field electroretinograms (ERGs), and multifocal ERGs (mfERGs). Morphological assessments included fundus photography, spectral-domain optical coherence tomography (SD-OCT), and adaptive optics (AO) fundus imaging. After the baseline clinical data were obtained, topical dorzolamide was applied to the patient. The patient was followed for 24 months. Results. A reported RS1 gene mutation was found (P203L) in the patient. At the baseline, his decimal BCVA was 0.15 in the right and 0.3 in the left eye. Fundus photographs showed bilateral spoke wheel-appearing maculopathy. SD-OCT confirmed the foveoschisis in the left eye. The AO images of the left eye showed spoke wheel retinal folds, and the folds were thinner than those in fundus photographs. During the follow-up period, the foveal thickness in the SD-OCT images and the number of retinal folds in the AO images were reduced. Conclusions. We have presented the detailed morphological changes of foveoschisis in a patient with XLRS detected by SD-OCT and AO fundus camera. However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

No MeSH data available.


Related in: MedlinePlus