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Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera.

Akeo K, Kameya S, Gocho K, Kubota D, Yamaki K, Takahashi H - Case Rep Ophthalmol Med (2015)

Bottom Line: A reported RS1 gene mutation was found (P203L) in the patient.Conclusions.However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba 270-1694, Japan.

ABSTRACT
Purpose. To report the morphological and functional changes associated with a regression of foveoschisis in a patient with X-linked retinoschisis (XLRS). Methods. A 42-year-old man with XLRS underwent genetic analysis and detailed ophthalmic examinations. Functional assessments included best-corrected visual acuity (BCVA), full-field electroretinograms (ERGs), and multifocal ERGs (mfERGs). Morphological assessments included fundus photography, spectral-domain optical coherence tomography (SD-OCT), and adaptive optics (AO) fundus imaging. After the baseline clinical data were obtained, topical dorzolamide was applied to the patient. The patient was followed for 24 months. Results. A reported RS1 gene mutation was found (P203L) in the patient. At the baseline, his decimal BCVA was 0.15 in the right and 0.3 in the left eye. Fundus photographs showed bilateral spoke wheel-appearing maculopathy. SD-OCT confirmed the foveoschisis in the left eye. The AO images of the left eye showed spoke wheel retinal folds, and the folds were thinner than those in fundus photographs. During the follow-up period, the foveal thickness in the SD-OCT images and the number of retinal folds in the AO images were reduced. Conclusions. We have presented the detailed morphological changes of foveoschisis in a patient with XLRS detected by SD-OCT and AO fundus camera. However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

No MeSH data available.


Related in: MedlinePlus

Time course of the changes in the full-field ERGs in the left eye of a patient with XLRS and a normal control is shown. The baseline of full-field ERGs recorded from the left eye of the patient and the same eye after 14 months of follow-up is shown on the top and middle row. The full-field ERGs of the normal control are shown in the bottom row. The dark-adapted 0.01, dark-adapted 3.0, light-adapted 3.0, and light-adapted 3.0 flicker ERGs of the full-field ERGs are shown. The amplitudes and implicit times of the full-field ERGs of the patient during the follow-up do not differ from those at the baseline.
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fig1: Time course of the changes in the full-field ERGs in the left eye of a patient with XLRS and a normal control is shown. The baseline of full-field ERGs recorded from the left eye of the patient and the same eye after 14 months of follow-up is shown on the top and middle row. The full-field ERGs of the normal control are shown in the bottom row. The dark-adapted 0.01, dark-adapted 3.0, light-adapted 3.0, and light-adapted 3.0 flicker ERGs of the full-field ERGs are shown. The amplitudes and implicit times of the full-field ERGs of the patient during the follow-up do not differ from those at the baseline.

Mentions: The decimal best-corrected visual acuity (BCVA) of our patient was 0.15 in the right eye and 0.3 in the left eye. The intraocular pressure and anterior ocular segments were normal in both eyes. The amplitudes of both the cone and the rod full-field ERGs were reduced, and the waveforms were similar in both eyes. The dark-adapted 3.0 b wave of the ERG had a negative-type pattern in both eyes (Figure 1). The amplitudes of the mfERGs were reduced in the fovea and also in the peripheral areas in both eyes (Figure 2). Goldmann visual field examination showed the presence of central scotomas in both eyes.


Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera.

Akeo K, Kameya S, Gocho K, Kubota D, Yamaki K, Takahashi H - Case Rep Ophthalmol Med (2015)

Time course of the changes in the full-field ERGs in the left eye of a patient with XLRS and a normal control is shown. The baseline of full-field ERGs recorded from the left eye of the patient and the same eye after 14 months of follow-up is shown on the top and middle row. The full-field ERGs of the normal control are shown in the bottom row. The dark-adapted 0.01, dark-adapted 3.0, light-adapted 3.0, and light-adapted 3.0 flicker ERGs of the full-field ERGs are shown. The amplitudes and implicit times of the full-field ERGs of the patient during the follow-up do not differ from those at the baseline.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4556076&req=5

fig1: Time course of the changes in the full-field ERGs in the left eye of a patient with XLRS and a normal control is shown. The baseline of full-field ERGs recorded from the left eye of the patient and the same eye after 14 months of follow-up is shown on the top and middle row. The full-field ERGs of the normal control are shown in the bottom row. The dark-adapted 0.01, dark-adapted 3.0, light-adapted 3.0, and light-adapted 3.0 flicker ERGs of the full-field ERGs are shown. The amplitudes and implicit times of the full-field ERGs of the patient during the follow-up do not differ from those at the baseline.
Mentions: The decimal best-corrected visual acuity (BCVA) of our patient was 0.15 in the right eye and 0.3 in the left eye. The intraocular pressure and anterior ocular segments were normal in both eyes. The amplitudes of both the cone and the rod full-field ERGs were reduced, and the waveforms were similar in both eyes. The dark-adapted 3.0 b wave of the ERG had a negative-type pattern in both eyes (Figure 1). The amplitudes of the mfERGs were reduced in the fovea and also in the peripheral areas in both eyes (Figure 2). Goldmann visual field examination showed the presence of central scotomas in both eyes.

Bottom Line: A reported RS1 gene mutation was found (P203L) in the patient.Conclusions.However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba 270-1694, Japan.

ABSTRACT
Purpose. To report the morphological and functional changes associated with a regression of foveoschisis in a patient with X-linked retinoschisis (XLRS). Methods. A 42-year-old man with XLRS underwent genetic analysis and detailed ophthalmic examinations. Functional assessments included best-corrected visual acuity (BCVA), full-field electroretinograms (ERGs), and multifocal ERGs (mfERGs). Morphological assessments included fundus photography, spectral-domain optical coherence tomography (SD-OCT), and adaptive optics (AO) fundus imaging. After the baseline clinical data were obtained, topical dorzolamide was applied to the patient. The patient was followed for 24 months. Results. A reported RS1 gene mutation was found (P203L) in the patient. At the baseline, his decimal BCVA was 0.15 in the right and 0.3 in the left eye. Fundus photographs showed bilateral spoke wheel-appearing maculopathy. SD-OCT confirmed the foveoschisis in the left eye. The AO images of the left eye showed spoke wheel retinal folds, and the folds were thinner than those in fundus photographs. During the follow-up period, the foveal thickness in the SD-OCT images and the number of retinal folds in the AO images were reduced. Conclusions. We have presented the detailed morphological changes of foveoschisis in a patient with XLRS detected by SD-OCT and AO fundus camera. However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

No MeSH data available.


Related in: MedlinePlus