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Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development.

Ayers D, Day PJ - Mol Biol Int (2015)

Bottom Line: The exponential development of highly advanced scientific and medical research technologies throughout the past 30 years has arrived to the point where the high number of characterized molecular agents related to pathogenesis cannot be readily integrated or processed by conventional analytical approaches.Indeed, the realization that several moieties are signatures of disease has partly led to the increment of complex diseases being characterized.Scientists and clinicians can now investigate and analyse any individual dysregulations occurring within the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks to currently available advanced technologies.

View Article: PubMed Central - PubMed

Affiliation: Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, Malta ; Faculty of Medical & Human Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.

ABSTRACT
The exponential development of highly advanced scientific and medical research technologies throughout the past 30 years has arrived to the point where the high number of characterized molecular agents related to pathogenesis cannot be readily integrated or processed by conventional analytical approaches. Indeed, the realization that several moieties are signatures of disease has partly led to the increment of complex diseases being characterized. Scientists and clinicians can now investigate and analyse any individual dysregulations occurring within the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks to currently available advanced technologies. However, there are drawbacks within this scientific brave new age in that only isolated molecular levels are individually investigated for their influence in affecting any particular health condition. Since their conception in 1992, systems biology/medicine focuses mainly on the perturbations of overall pathway kinetics for the consequent onset and/or deterioration of the investigated condition/s. Systems medicine approaches can therefore be employed for shedding light in multiple research scenarios, ultimately leading to the practical result of uncovering novel dynamic interaction networks that are critical for influencing the course of medical conditions. Consequently, systems medicine also serves to identify clinically important molecular targets for diagnostic and therapeutic measures against such a condition.

No MeSH data available.


Related in: MedlinePlus

Overview of the required facets for implementation of systems medicine approaches to modern medical research.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig2: Overview of the required facets for implementation of systems medicine approaches to modern medical research.

Mentions: The traditional reductionist approach to medical research has been discussed and can be restricted to the investigation of the biological effects of individual or minute quantities of key molecular players for complex, multifactorial human conditions, including cancer. The application of systems biology within the remit of present day medical research can be defined as systems medicine, its concept dating back to 1992 [9]. Such a wider perspective opens new doors of perception and insight into the holistic nature of such disease conditions, focusing mainly on the perturbations of overall pathway kinetics for the consequent onset and/or deterioration of the investigated condition/s. Systems medicine requires the employment of several vital facets in order to attain its clinical theranostic goals whenever such an approach is implemented [35] (see Figure 2).


Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development.

Ayers D, Day PJ - Mol Biol Int (2015)

Overview of the required facets for implementation of systems medicine approaches to modern medical research.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4556074&req=5

fig2: Overview of the required facets for implementation of systems medicine approaches to modern medical research.
Mentions: The traditional reductionist approach to medical research has been discussed and can be restricted to the investigation of the biological effects of individual or minute quantities of key molecular players for complex, multifactorial human conditions, including cancer. The application of systems biology within the remit of present day medical research can be defined as systems medicine, its concept dating back to 1992 [9]. Such a wider perspective opens new doors of perception and insight into the holistic nature of such disease conditions, focusing mainly on the perturbations of overall pathway kinetics for the consequent onset and/or deterioration of the investigated condition/s. Systems medicine requires the employment of several vital facets in order to attain its clinical theranostic goals whenever such an approach is implemented [35] (see Figure 2).

Bottom Line: The exponential development of highly advanced scientific and medical research technologies throughout the past 30 years has arrived to the point where the high number of characterized molecular agents related to pathogenesis cannot be readily integrated or processed by conventional analytical approaches.Indeed, the realization that several moieties are signatures of disease has partly led to the increment of complex diseases being characterized.Scientists and clinicians can now investigate and analyse any individual dysregulations occurring within the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks to currently available advanced technologies.

View Article: PubMed Central - PubMed

Affiliation: Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, Malta ; Faculty of Medical & Human Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.

ABSTRACT
The exponential development of highly advanced scientific and medical research technologies throughout the past 30 years has arrived to the point where the high number of characterized molecular agents related to pathogenesis cannot be readily integrated or processed by conventional analytical approaches. Indeed, the realization that several moieties are signatures of disease has partly led to the increment of complex diseases being characterized. Scientists and clinicians can now investigate and analyse any individual dysregulations occurring within the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks to currently available advanced technologies. However, there are drawbacks within this scientific brave new age in that only isolated molecular levels are individually investigated for their influence in affecting any particular health condition. Since their conception in 1992, systems biology/medicine focuses mainly on the perturbations of overall pathway kinetics for the consequent onset and/or deterioration of the investigated condition/s. Systems medicine approaches can therefore be employed for shedding light in multiple research scenarios, ultimately leading to the practical result of uncovering novel dynamic interaction networks that are critical for influencing the course of medical conditions. Consequently, systems medicine also serves to identify clinically important molecular targets for diagnostic and therapeutic measures against such a condition.

No MeSH data available.


Related in: MedlinePlus