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Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development.

Ayers D, Day PJ - Mol Biol Int (2015)

Bottom Line: The exponential development of highly advanced scientific and medical research technologies throughout the past 30 years has arrived to the point where the high number of characterized molecular agents related to pathogenesis cannot be readily integrated or processed by conventional analytical approaches.Indeed, the realization that several moieties are signatures of disease has partly led to the increment of complex diseases being characterized.Scientists and clinicians can now investigate and analyse any individual dysregulations occurring within the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks to currently available advanced technologies.

View Article: PubMed Central - PubMed

Affiliation: Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, Malta ; Faculty of Medical & Human Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.

ABSTRACT
The exponential development of highly advanced scientific and medical research technologies throughout the past 30 years has arrived to the point where the high number of characterized molecular agents related to pathogenesis cannot be readily integrated or processed by conventional analytical approaches. Indeed, the realization that several moieties are signatures of disease has partly led to the increment of complex diseases being characterized. Scientists and clinicians can now investigate and analyse any individual dysregulations occurring within the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks to currently available advanced technologies. However, there are drawbacks within this scientific brave new age in that only isolated molecular levels are individually investigated for their influence in affecting any particular health condition. Since their conception in 1992, systems biology/medicine focuses mainly on the perturbations of overall pathway kinetics for the consequent onset and/or deterioration of the investigated condition/s. Systems medicine approaches can therefore be employed for shedding light in multiple research scenarios, ultimately leading to the practical result of uncovering novel dynamic interaction networks that are critical for influencing the course of medical conditions. Consequently, systems medicine also serves to identify clinically important molecular targets for diagnostic and therapeutic measures against such a condition.

No MeSH data available.


Related in: MedlinePlus

Overview of the main concepts for conventional (reductionist) and systems approaches to modern medical research.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Overview of the main concepts for conventional (reductionist) and systems approaches to modern medical research.

Mentions: In essence, the field of systems biology revolves around the principle that the phenotype of any individual living organism is a reflection of the simultaneous multitude of molecular interactions from various levels occurring at any one time, combined in a holistic manner to produce such a phenotype (see Figure 1) [3]. Consequently, against the standard concept of reductionist approach where dysregulations in isolated molecular components are studied, data from dysregulations of multiple key molecular players from varying cellular levels of activity are pooled and studied in their entirety, for the purpose of identifying distinct changes in the pattern of intermolecular relationships, vis a vis the organism's investigated phenotypes [3, 4]. The methods applied as the principal research tools vary, depending on the nature of the molecular level being investigated and also on the volumes of data generated; therefore, nowadays most self-sufficient systems biology research groups are composed of research scientists with a discernable knowledge of experimental investigation for most molecular level research and/or are unique experts in their own specific research field. Consequently, systems biology is very much an interdisciplinary field of research, requiring the technology platforms and research expertise of individuals from a spectrum of scientific research niche [3, 4]. However, the measurement of all molecular parts of an organ or even biomedical pathway is far from routinely achievable, and great efforts to improve sensitivity of analysis and to make the output data possess a quantitative significance are starting to improve through implementation of field standards [5, 6]. Given current constraints, Boolean approaches are assisting with production of 1st generation systems biology models [7]. A main difference between systems biology and systems medicine is that the former assumes the data to be correct and useable as often wet-lab data generation expertise is not the main goal but is assumed to be correct and useable. Systems medicine (sometimes referred to as systems healthcare) promises to lead with clinical and molecular know-how to produce exquisite datasets that are employed to generate pathway models and treatment and will hopefully directly contribute to stratified medicine en-route to personalized healthcare [4, 8–11].


Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development.

Ayers D, Day PJ - Mol Biol Int (2015)

Overview of the main concepts for conventional (reductionist) and systems approaches to modern medical research.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4556074&req=5

fig1: Overview of the main concepts for conventional (reductionist) and systems approaches to modern medical research.
Mentions: In essence, the field of systems biology revolves around the principle that the phenotype of any individual living organism is a reflection of the simultaneous multitude of molecular interactions from various levels occurring at any one time, combined in a holistic manner to produce such a phenotype (see Figure 1) [3]. Consequently, against the standard concept of reductionist approach where dysregulations in isolated molecular components are studied, data from dysregulations of multiple key molecular players from varying cellular levels of activity are pooled and studied in their entirety, for the purpose of identifying distinct changes in the pattern of intermolecular relationships, vis a vis the organism's investigated phenotypes [3, 4]. The methods applied as the principal research tools vary, depending on the nature of the molecular level being investigated and also on the volumes of data generated; therefore, nowadays most self-sufficient systems biology research groups are composed of research scientists with a discernable knowledge of experimental investigation for most molecular level research and/or are unique experts in their own specific research field. Consequently, systems biology is very much an interdisciplinary field of research, requiring the technology platforms and research expertise of individuals from a spectrum of scientific research niche [3, 4]. However, the measurement of all molecular parts of an organ or even biomedical pathway is far from routinely achievable, and great efforts to improve sensitivity of analysis and to make the output data possess a quantitative significance are starting to improve through implementation of field standards [5, 6]. Given current constraints, Boolean approaches are assisting with production of 1st generation systems biology models [7]. A main difference between systems biology and systems medicine is that the former assumes the data to be correct and useable as often wet-lab data generation expertise is not the main goal but is assumed to be correct and useable. Systems medicine (sometimes referred to as systems healthcare) promises to lead with clinical and molecular know-how to produce exquisite datasets that are employed to generate pathway models and treatment and will hopefully directly contribute to stratified medicine en-route to personalized healthcare [4, 8–11].

Bottom Line: The exponential development of highly advanced scientific and medical research technologies throughout the past 30 years has arrived to the point where the high number of characterized molecular agents related to pathogenesis cannot be readily integrated or processed by conventional analytical approaches.Indeed, the realization that several moieties are signatures of disease has partly led to the increment of complex diseases being characterized.Scientists and clinicians can now investigate and analyse any individual dysregulations occurring within the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks to currently available advanced technologies.

View Article: PubMed Central - PubMed

Affiliation: Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, Malta ; Faculty of Medical & Human Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.

ABSTRACT
The exponential development of highly advanced scientific and medical research technologies throughout the past 30 years has arrived to the point where the high number of characterized molecular agents related to pathogenesis cannot be readily integrated or processed by conventional analytical approaches. Indeed, the realization that several moieties are signatures of disease has partly led to the increment of complex diseases being characterized. Scientists and clinicians can now investigate and analyse any individual dysregulations occurring within the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks to currently available advanced technologies. However, there are drawbacks within this scientific brave new age in that only isolated molecular levels are individually investigated for their influence in affecting any particular health condition. Since their conception in 1992, systems biology/medicine focuses mainly on the perturbations of overall pathway kinetics for the consequent onset and/or deterioration of the investigated condition/s. Systems medicine approaches can therefore be employed for shedding light in multiple research scenarios, ultimately leading to the practical result of uncovering novel dynamic interaction networks that are critical for influencing the course of medical conditions. Consequently, systems medicine also serves to identify clinically important molecular targets for diagnostic and therapeutic measures against such a condition.

No MeSH data available.


Related in: MedlinePlus