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Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 T with 3D spectral-spatial EPI.

Miller JJ, Lau AZ, Teh I, Schneider JE, Kinchesh P, Smart S, Ball V, Sibson NR, Tyler DJ - Magn Reson Med (2015)

Bottom Line: Significant differences in myocardial pyruvate dehydrogenase flux were observed between the three groups of animals, concomitant with the known biochemistry.The field of view enabled the simultaneous multi-organ acquisition of metabolic information from the rat, which is of great utility for preclinical research in cardiovascular disease.Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Clarendon Laboratory, University of Oxford, England, UK.

No MeSH data available.


Related in: MedlinePlus

Representative single-slice whole-heart time courses acquired from fasted animals (a), fed animals (b), and animals fed and administered DCA (c).
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Figure 6: Representative single-slice whole-heart time courses acquired from fasted animals (a), fed animals (b), and animals fed and administered DCA (c).

Mentions: The temporal resolution of the technique was sufficient to resolve metabolic dynamics following injection of hyperpolarized [1-13C]pyruvate in a single voxel. Concomitantly with the known anatomy, pyruvate was observed perfusing the great vessels at early times, before arriving in the right and then left ventricles. Myocardial bicarbonate and lactate production subsequently followed. Summing the data acquired in a manually segmented ROI over the heart allowed for the reconstruction of metabolic dynamic time-courses (Fig. 6), as expected.


Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 T with 3D spectral-spatial EPI.

Miller JJ, Lau AZ, Teh I, Schneider JE, Kinchesh P, Smart S, Ball V, Sibson NR, Tyler DJ - Magn Reson Med (2015)

Representative single-slice whole-heart time courses acquired from fasted animals (a), fed animals (b), and animals fed and administered DCA (c).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556070&req=5

Figure 6: Representative single-slice whole-heart time courses acquired from fasted animals (a), fed animals (b), and animals fed and administered DCA (c).
Mentions: The temporal resolution of the technique was sufficient to resolve metabolic dynamics following injection of hyperpolarized [1-13C]pyruvate in a single voxel. Concomitantly with the known anatomy, pyruvate was observed perfusing the great vessels at early times, before arriving in the right and then left ventricles. Myocardial bicarbonate and lactate production subsequently followed. Summing the data acquired in a manually segmented ROI over the heart allowed for the reconstruction of metabolic dynamic time-courses (Fig. 6), as expected.

Bottom Line: Significant differences in myocardial pyruvate dehydrogenase flux were observed between the three groups of animals, concomitant with the known biochemistry.The field of view enabled the simultaneous multi-organ acquisition of metabolic information from the rat, which is of great utility for preclinical research in cardiovascular disease.Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Clarendon Laboratory, University of Oxford, England, UK.

No MeSH data available.


Related in: MedlinePlus