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Potentiated clinoptilolite reduces signs and symptoms associated with veisalgia.

Gandy JJ, Laurens I, Snyman JR - Clin Exp Gastroenterol (2015)

Bottom Line: Abundant anecdotal evidence for products claiming to reduce veisalgia after alcohol overindulgence are available on the Internet and as many advertisements in journals.This research indicates that Absorbatox™ does not have an effect on blood- or breath-alcohol levels.Furthermore, treatment with Absorbatox™ resulted in an overall significant reduction in central nervous system and gastrointestinal tract symptoms associated with veisalgia, warranting further investigation.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, Gauteng, South Africa.

ABSTRACT

Introduction: Abundant anecdotal evidence for products claiming to reduce veisalgia after alcohol overindulgence are available on the Internet and as many advertisements in journals. None of these claims are, however, substantiated by research. The aim of this research was to ascertain the validity of such claims for the substance Absorbatox™, a potentiated aluminosilicate (cation exchanger able to bind NH(4+), histamine, and other positively charged ions) by investigating the signs and symptoms, as well as blood or breath alcohol levels, in healthy volunteers.

Methods: Blood or breath alcohol levels were measured in all volunteers in initial controlled experiments, and symptoms were scored on a diary card for gastrointestinal tract symptoms, as well as other symptoms such as headache and light sensitivity. Eighteen volunteers completed the initial blood alcohol study, which investigated the effect of Absorbatox™ on blood alcohol levels after fasting. The follow-up studies researched the effects of the symptoms and signs of alcohol overindulgence. The "night out" study was completed by ten volunteers in a typical controlled environment, which was followed by the real-life four-leg crossover study. In the crossover study, volunteers (number =25 completers) had to fill matching diary cards to containers of two placebo and two active drugs after a night out where they themselves decided on the container (color coded) to be used and the amount of alcohol to be consumed.

Results: Absorbatox™ had no effect on blood alcohol levels, but it significantly reduced the symptoms and signs of veisalgia by approximately 40%-50%.

Conclusion: This research indicates that Absorbatox™ does not have an effect on blood- or breath-alcohol levels. Furthermore, treatment with Absorbatox™ resulted in an overall significant reduction in central nervous system and gastrointestinal tract symptoms associated with veisalgia, warranting further investigation.

No MeSH data available.


Related in: MedlinePlus

Patients’ mean blood alcohol concentration from study A.Notes: No significant difference in blood alcohol concentrations at different time intervals were obtained between the group taking Absorbatox™ versus those in the placebo group. Study A is the effect of Absorbatox™ on alcohol absorption while fasting: determination of peak blood alcohol concentrations.Abbreviation: min, minutes.
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f1-ceg-8-271: Patients’ mean blood alcohol concentration from study A.Notes: No significant difference in blood alcohol concentrations at different time intervals were obtained between the group taking Absorbatox™ versus those in the placebo group. Study A is the effect of Absorbatox™ on alcohol absorption while fasting: determination of peak blood alcohol concentrations.Abbreviation: min, minutes.

Mentions: It was proven that there were no significant differences in the blood alcohol concentrations at the different time intervals (time =0, 30, 60, 90, 120, or 240 minutes) between the groups taking Absorbatox™ vs the placebo group (Figure 1). Absorbatox™ did not reduce the blood alcohol concentrations of participants who ingested three drinks (33 mL EtOH) over a 30-minute period. There was also no delay in the absorption, reflecting a normal gastric emptying time (motility not affected).


Potentiated clinoptilolite reduces signs and symptoms associated with veisalgia.

Gandy JJ, Laurens I, Snyman JR - Clin Exp Gastroenterol (2015)

Patients’ mean blood alcohol concentration from study A.Notes: No significant difference in blood alcohol concentrations at different time intervals were obtained between the group taking Absorbatox™ versus those in the placebo group. Study A is the effect of Absorbatox™ on alcohol absorption while fasting: determination of peak blood alcohol concentrations.Abbreviation: min, minutes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555977&req=5

f1-ceg-8-271: Patients’ mean blood alcohol concentration from study A.Notes: No significant difference in blood alcohol concentrations at different time intervals were obtained between the group taking Absorbatox™ versus those in the placebo group. Study A is the effect of Absorbatox™ on alcohol absorption while fasting: determination of peak blood alcohol concentrations.Abbreviation: min, minutes.
Mentions: It was proven that there were no significant differences in the blood alcohol concentrations at the different time intervals (time =0, 30, 60, 90, 120, or 240 minutes) between the groups taking Absorbatox™ vs the placebo group (Figure 1). Absorbatox™ did not reduce the blood alcohol concentrations of participants who ingested three drinks (33 mL EtOH) over a 30-minute period. There was also no delay in the absorption, reflecting a normal gastric emptying time (motility not affected).

Bottom Line: Abundant anecdotal evidence for products claiming to reduce veisalgia after alcohol overindulgence are available on the Internet and as many advertisements in journals.This research indicates that Absorbatox™ does not have an effect on blood- or breath-alcohol levels.Furthermore, treatment with Absorbatox™ resulted in an overall significant reduction in central nervous system and gastrointestinal tract symptoms associated with veisalgia, warranting further investigation.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, Gauteng, South Africa.

ABSTRACT

Introduction: Abundant anecdotal evidence for products claiming to reduce veisalgia after alcohol overindulgence are available on the Internet and as many advertisements in journals. None of these claims are, however, substantiated by research. The aim of this research was to ascertain the validity of such claims for the substance Absorbatox™, a potentiated aluminosilicate (cation exchanger able to bind NH(4+), histamine, and other positively charged ions) by investigating the signs and symptoms, as well as blood or breath alcohol levels, in healthy volunteers.

Methods: Blood or breath alcohol levels were measured in all volunteers in initial controlled experiments, and symptoms were scored on a diary card for gastrointestinal tract symptoms, as well as other symptoms such as headache and light sensitivity. Eighteen volunteers completed the initial blood alcohol study, which investigated the effect of Absorbatox™ on blood alcohol levels after fasting. The follow-up studies researched the effects of the symptoms and signs of alcohol overindulgence. The "night out" study was completed by ten volunteers in a typical controlled environment, which was followed by the real-life four-leg crossover study. In the crossover study, volunteers (number =25 completers) had to fill matching diary cards to containers of two placebo and two active drugs after a night out where they themselves decided on the container (color coded) to be used and the amount of alcohol to be consumed.

Results: Absorbatox™ had no effect on blood alcohol levels, but it significantly reduced the symptoms and signs of veisalgia by approximately 40%-50%.

Conclusion: This research indicates that Absorbatox™ does not have an effect on blood- or breath-alcohol levels. Furthermore, treatment with Absorbatox™ resulted in an overall significant reduction in central nervous system and gastrointestinal tract symptoms associated with veisalgia, warranting further investigation.

No MeSH data available.


Related in: MedlinePlus