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Giant molluscum contagiosum with granulomatous inflammation and panniculitis: An unusual clinical and histopathological pattern in an HIV seropositive child.

Poojary SA, Kokane PT - Indian J Sex Transm Dis (2015 Jan-Jun)

Bottom Line: Molluscum contagiosum is known to occur in the advanced stages of immunodeficiency in HIV infected patients and may present as atypical variants including giant molluscum.Here we describe the rare occurrence of giant molluscum contagiosum in an HIV seropositive child, which warranted surgical excision followed by skin grafting due to its unusually large size.We also highlight in this case report, a rare granulomatous inflammatory reaction pattern to molluscum with panniculitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology and Leprology, K.J Somaiya Medical College and Research Centre, Mumbai, Maharashtra, India.

ABSTRACT
Molluscum contagiosum is known to occur in the advanced stages of immunodeficiency in HIV infected patients and may present as atypical variants including giant molluscum. Here we describe the rare occurrence of giant molluscum contagiosum in an HIV seropositive child, which warranted surgical excision followed by skin grafting due to its unusually large size. We also highlight in this case report, a rare granulomatous inflammatory reaction pattern to molluscum with panniculitis.

No MeSH data available.


Related in: MedlinePlus

Single, well defined, lobulated, tumoral swelling (5 cm × 6 cm × 7 cm in size) on the left cheek. Surface of the swelling showed few pearly white flat topped papules, ulceration with hemorrhagic crust and slough. Multiple, discrete, pearly white, umbilicated papules were present over surrounding skin
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Figure 1: Single, well defined, lobulated, tumoral swelling (5 cm × 6 cm × 7 cm in size) on the left cheek. Surface of the swelling showed few pearly white flat topped papules, ulceration with hemorrhagic crust and slough. Multiple, discrete, pearly white, umbilicated papules were present over surrounding skin

Mentions: On examination there was a single, well defined, lobulated, tumoral swelling 5 cm × 6 cm × 7 cm in size on the left cheek [Figure 1]. Skin overlying the swelling was thinned out with surface showing evidence of ulceration, haemorrhagic crust with slough. Swelling was freely mobile over underlying structures. Multiple, discrete, pearly white, umbilicated papules were present over cheek, forehead, upper eyelids, nose, lower extremities and buttocks. There was no lymphadenopathy. Systemic examination including central nervous system examination was normal. A differential diagnosis of giant molluscum contagiosum, keratoacanthoma, squamous cell carcinoma and cryptococcosis was considered.


Giant molluscum contagiosum with granulomatous inflammation and panniculitis: An unusual clinical and histopathological pattern in an HIV seropositive child.

Poojary SA, Kokane PT - Indian J Sex Transm Dis (2015 Jan-Jun)

Single, well defined, lobulated, tumoral swelling (5 cm × 6 cm × 7 cm in size) on the left cheek. Surface of the swelling showed few pearly white flat topped papules, ulceration with hemorrhagic crust and slough. Multiple, discrete, pearly white, umbilicated papules were present over surrounding skin
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555913&req=5

Figure 1: Single, well defined, lobulated, tumoral swelling (5 cm × 6 cm × 7 cm in size) on the left cheek. Surface of the swelling showed few pearly white flat topped papules, ulceration with hemorrhagic crust and slough. Multiple, discrete, pearly white, umbilicated papules were present over surrounding skin
Mentions: On examination there was a single, well defined, lobulated, tumoral swelling 5 cm × 6 cm × 7 cm in size on the left cheek [Figure 1]. Skin overlying the swelling was thinned out with surface showing evidence of ulceration, haemorrhagic crust with slough. Swelling was freely mobile over underlying structures. Multiple, discrete, pearly white, umbilicated papules were present over cheek, forehead, upper eyelids, nose, lower extremities and buttocks. There was no lymphadenopathy. Systemic examination including central nervous system examination was normal. A differential diagnosis of giant molluscum contagiosum, keratoacanthoma, squamous cell carcinoma and cryptococcosis was considered.

Bottom Line: Molluscum contagiosum is known to occur in the advanced stages of immunodeficiency in HIV infected patients and may present as atypical variants including giant molluscum.Here we describe the rare occurrence of giant molluscum contagiosum in an HIV seropositive child, which warranted surgical excision followed by skin grafting due to its unusually large size.We also highlight in this case report, a rare granulomatous inflammatory reaction pattern to molluscum with panniculitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology and Leprology, K.J Somaiya Medical College and Research Centre, Mumbai, Maharashtra, India.

ABSTRACT
Molluscum contagiosum is known to occur in the advanced stages of immunodeficiency in HIV infected patients and may present as atypical variants including giant molluscum. Here we describe the rare occurrence of giant molluscum contagiosum in an HIV seropositive child, which warranted surgical excision followed by skin grafting due to its unusually large size. We also highlight in this case report, a rare granulomatous inflammatory reaction pattern to molluscum with panniculitis.

No MeSH data available.


Related in: MedlinePlus