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Multiple osteolytic lesions in a 14-year-old boy with HIV disease.

Murugan S - Indian J Sex Transm Dis (2015 Jan-Jun)

Bottom Line: Now the boy is on ART (ZDV + 3TC + EFV) since August 2013.His CD4 count improved and viral load became undetectable and he gained weight within 5 months of ART.Due to the rarity of its presentation, this case report is being reported.

View Article: PubMed Central - PubMed

Affiliation: Department of STD, SHIFA Hospitals, Tirunelveli, Tamil Nadu, India.

ABSTRACT
A 14 year old boy, said to have had multiple transfusions during infancy, was brought to the hospital for complaints of pain over right thigh for one week duration. MRI reveals multiple osteolytic lesions with enhancing hyperintense bone marrow lesions over iliac bones, right acetabulum and lumbar vertebral bodies and enlarged para-aortic, iliac and inguinal lymph nodes. CT of the whole body revealed osteolytic lesions on skull, mandible, right scapula, head of both humeri, L1 and L4 vertebrae, 5(th) and 10(th) ribs, both acetabulum and ala of sacrum along with enlargement of cervical, axillary and mesenteric, iliac and inguinal nodes. HIV ELISA was positive. Viral load was 141,700 copies/ml. CD4 count was 226 cells/mm(3). Multiple biopsy from the lesions and bone marrow revealed no evidence of tuberculosis and malignancy. Now the boy is on ART (ZDV + 3TC + EFV) since August 2013. His CD4 count improved and viral load became undetectable and he gained weight within 5 months of ART. Due to the rarity of its presentation, this case report is being reported.

No MeSH data available.


Related in: MedlinePlus

Before antiretroviral therapy computed tomography scan 2
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Figure 2: Before antiretroviral therapy computed tomography scan 2

Mentions: Computed tomography of the whole body revealed osteolytic lesions on skull, mandible, right scapula, head of both humeri, L1 and L4 Vertebrae, 5th and 10th ribs, both acetabulum and ala of sacrum and enlargement of cervical, axillary, mesenteric, iliac and inguinal nodes (Figures 1 and 2). Magnetic resonance imaging of pelvis revealed multiple osteolytic lesions over both acetabulum and a larger one over the ala of Sacrum. Enhancing hyperintense bone marrow lesions of iliac bones, right acetabulum and lumbar vertebral bodies were noticed along with enlarged para-aortic, iliac and inguinal lymph nodes [Figure 3].


Multiple osteolytic lesions in a 14-year-old boy with HIV disease.

Murugan S - Indian J Sex Transm Dis (2015 Jan-Jun)

Before antiretroviral therapy computed tomography scan 2
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555912&req=5

Figure 2: Before antiretroviral therapy computed tomography scan 2
Mentions: Computed tomography of the whole body revealed osteolytic lesions on skull, mandible, right scapula, head of both humeri, L1 and L4 Vertebrae, 5th and 10th ribs, both acetabulum and ala of sacrum and enlargement of cervical, axillary, mesenteric, iliac and inguinal nodes (Figures 1 and 2). Magnetic resonance imaging of pelvis revealed multiple osteolytic lesions over both acetabulum and a larger one over the ala of Sacrum. Enhancing hyperintense bone marrow lesions of iliac bones, right acetabulum and lumbar vertebral bodies were noticed along with enlarged para-aortic, iliac and inguinal lymph nodes [Figure 3].

Bottom Line: Now the boy is on ART (ZDV + 3TC + EFV) since August 2013.His CD4 count improved and viral load became undetectable and he gained weight within 5 months of ART.Due to the rarity of its presentation, this case report is being reported.

View Article: PubMed Central - PubMed

Affiliation: Department of STD, SHIFA Hospitals, Tirunelveli, Tamil Nadu, India.

ABSTRACT
A 14 year old boy, said to have had multiple transfusions during infancy, was brought to the hospital for complaints of pain over right thigh for one week duration. MRI reveals multiple osteolytic lesions with enhancing hyperintense bone marrow lesions over iliac bones, right acetabulum and lumbar vertebral bodies and enlarged para-aortic, iliac and inguinal lymph nodes. CT of the whole body revealed osteolytic lesions on skull, mandible, right scapula, head of both humeri, L1 and L4 vertebrae, 5(th) and 10(th) ribs, both acetabulum and ala of sacrum along with enlargement of cervical, axillary and mesenteric, iliac and inguinal nodes. HIV ELISA was positive. Viral load was 141,700 copies/ml. CD4 count was 226 cells/mm(3). Multiple biopsy from the lesions and bone marrow revealed no evidence of tuberculosis and malignancy. Now the boy is on ART (ZDV + 3TC + EFV) since August 2013. His CD4 count improved and viral load became undetectable and he gained weight within 5 months of ART. Due to the rarity of its presentation, this case report is being reported.

No MeSH data available.


Related in: MedlinePlus