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Squamous cell carcinoma on a syphilitic gumma: A unique presentation.

Rahima S, Riyaz N, Latheef EN, Shyni PM - Indian J Sex Transm Dis (2015 Jan-Jun)

Bottom Line: Examination revealed a well-defined ulcer with a perforation of 1.5 cm over the hard palate with induration and nodularity at the margins.To conclude, this is a unique presentation of syphilitic gumma with palatal perforation with SCC and syphilitic leukoplakia with Ca in situ over tongue.Thus, serology for syphilis should be done in all patients with SCC of the oral cavity.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology, Leprosy, Government Medical College, Kozhikode, Kerala, India.

ABSTRACT
Gumma is a characteristic lesion of tertiary syphilis that is rare nowadays, but still rarer is squamous cell carcinoma (SCC) arising from it. A 74-year-old male presented with throat pain and nasal twang with a past history of genital ulcer. Examination revealed a well-defined ulcer with a perforation of 1.5 cm over the hard palate with induration and nodularity at the margins. This patient also had leukoplakia over the ventral aspect of the tongue. His treponema pallidum hemagglutination assay was positive, and biopsy revealed well-differentiated SCC from the lesion over the palate and leukoplakia with dysplasia from the lesion over the tongue. Patient is on treatment from radiotherapy. To conclude, this is a unique presentation of syphilitic gumma with palatal perforation with SCC and syphilitic leukoplakia with Ca in situ over tongue. Thus, serology for syphilis should be done in all patients with SCC of the oral cavity.

No MeSH data available.


Related in: MedlinePlus

Leukoplakia over the ventral aspect of the tongue
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Figure 1: Leukoplakia over the ventral aspect of the tongue

Mentions: A 74-year-old man presented to our department with a history of nasal twang and nasal regurgitation since many years. He also had a swelling over the palate that ulcerated since 1 month. He gives a history of penile ulcer at the age of 18 following a premarital exposure. On examination, there was a white patch of 1 cm × 1 cm over the ventral aspect of the tongue [Figure 1]. There was also a perforation of 1.5 cm × 1 cm over the hard palate with induration and sloughing at the margins [Figure 2]. An atrophic scar of 2 cm × 2 cm was present over the prepuce. There was a firm to hard cervical lymphadenopathy. Neurological evaluation revealed features suggestive of bilateral pyramidal signs. His erythrocyte sedimentation rate was raised, venereal disease research laboratory (VDRL) was 1:1 and treponema pallidum hemagglutination assay was positive. His cerebrospinal fluid VDRL and HIV were negative. Biopsy from palatal lesion showed squamous cells with nuclear hyperchromasia and high mitotic index extending beyond the basement membrane [Figure 3a]. Epithelial pearl/keratin whorl/malignant pearl was seen as concentric squames of keratin within an epithelial island [Figure 3b]. There was also areas of necrosis with surrounding lymphocytic infiltrate [Figure 3c]. Biopsy from the leukoplakia of the tongue showed marked epithelial dysplasia with an intact basement membrane. There was cellular atypia with hyperchromatic nuclei [Figure 4]. Patient was treated with doxycycline twice a day for 28 days and was referred to surgery and radiotherapy for further management.


Squamous cell carcinoma on a syphilitic gumma: A unique presentation.

Rahima S, Riyaz N, Latheef EN, Shyni PM - Indian J Sex Transm Dis (2015 Jan-Jun)

Leukoplakia over the ventral aspect of the tongue
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555910&req=5

Figure 1: Leukoplakia over the ventral aspect of the tongue
Mentions: A 74-year-old man presented to our department with a history of nasal twang and nasal regurgitation since many years. He also had a swelling over the palate that ulcerated since 1 month. He gives a history of penile ulcer at the age of 18 following a premarital exposure. On examination, there was a white patch of 1 cm × 1 cm over the ventral aspect of the tongue [Figure 1]. There was also a perforation of 1.5 cm × 1 cm over the hard palate with induration and sloughing at the margins [Figure 2]. An atrophic scar of 2 cm × 2 cm was present over the prepuce. There was a firm to hard cervical lymphadenopathy. Neurological evaluation revealed features suggestive of bilateral pyramidal signs. His erythrocyte sedimentation rate was raised, venereal disease research laboratory (VDRL) was 1:1 and treponema pallidum hemagglutination assay was positive. His cerebrospinal fluid VDRL and HIV were negative. Biopsy from palatal lesion showed squamous cells with nuclear hyperchromasia and high mitotic index extending beyond the basement membrane [Figure 3a]. Epithelial pearl/keratin whorl/malignant pearl was seen as concentric squames of keratin within an epithelial island [Figure 3b]. There was also areas of necrosis with surrounding lymphocytic infiltrate [Figure 3c]. Biopsy from the leukoplakia of the tongue showed marked epithelial dysplasia with an intact basement membrane. There was cellular atypia with hyperchromatic nuclei [Figure 4]. Patient was treated with doxycycline twice a day for 28 days and was referred to surgery and radiotherapy for further management.

Bottom Line: Examination revealed a well-defined ulcer with a perforation of 1.5 cm over the hard palate with induration and nodularity at the margins.To conclude, this is a unique presentation of syphilitic gumma with palatal perforation with SCC and syphilitic leukoplakia with Ca in situ over tongue.Thus, serology for syphilis should be done in all patients with SCC of the oral cavity.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology, Leprosy, Government Medical College, Kozhikode, Kerala, India.

ABSTRACT
Gumma is a characteristic lesion of tertiary syphilis that is rare nowadays, but still rarer is squamous cell carcinoma (SCC) arising from it. A 74-year-old male presented with throat pain and nasal twang with a past history of genital ulcer. Examination revealed a well-defined ulcer with a perforation of 1.5 cm over the hard palate with induration and nodularity at the margins. This patient also had leukoplakia over the ventral aspect of the tongue. His treponema pallidum hemagglutination assay was positive, and biopsy revealed well-differentiated SCC from the lesion over the palate and leukoplakia with dysplasia from the lesion over the tongue. Patient is on treatment from radiotherapy. To conclude, this is a unique presentation of syphilitic gumma with palatal perforation with SCC and syphilitic leukoplakia with Ca in situ over tongue. Thus, serology for syphilis should be done in all patients with SCC of the oral cavity.

No MeSH data available.


Related in: MedlinePlus