Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation.
Bottom Line: In nonneuronal cells, protein kinase D (PKD) has an important role in stabilizing F-actin via multiple molecular pathways.Consequently, impaired PKD functions attenuate activity-dependent changes in hippocampal dendritic spines, including LTP formation, cause morphological alterations in vivo, and have deleterious consequences on spatial memory formation.We thus provide compelling evidence that PKD controls synaptic plasticity and learning by regulating actin stability in dendritic spines.
Affiliation: Department of Physiology and Neurobiology, Eötvös Loránd University, H-1117 Budapest, Hungary.Show MeSH
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Mentions: To assess neuron-specific functions of PKD in vivo, we used a transgenic TetOn mouse line, allowing inducible expression of the dominant-negative kdPKD-EGFP protein (Czöndör et al., 2009). For better readability, doxycycline (DOX)-treated CaMKIIα-rtTA2 × kdPKD-EGFP double transgenic mice are named kdPKD-EGFP–expressing mice, whereas single transgenic littermates treated with DOX are referred to as the control group (Fig. 4, and Fig. 5, and Fig. S3).
Affiliation: Department of Physiology and Neurobiology, Eötvös Loránd University, H-1117 Budapest, Hungary.