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Chemically modified tetracyclines: The novel host modulating agents.

Swamy DN, Sanivarapu S, Moogla S, Kapalavai V - J Indian Soc Periodontol (2015 Jul-Aug)

Bottom Line: A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins.Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property.The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.

ABSTRACT
Periodontal pathogens and destructive host responses are involved in the initiation and progression of periodontitis. The emergence of host response modulation as a treatment concept has resulted from our improved understanding of the pathogenesis of periodontal disease. A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins. Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property. The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

No MeSH data available.


Related in: MedlinePlus

Schematic illustration of the pathogenesis of periodontitis, including targets for host modulation, depicting the action of CMTs on MMPs
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Figure 6: Schematic illustration of the pathogenesis of periodontitis, including targets for host modulation, depicting the action of CMTs on MMPs

Mentions: CMTs are used as HMT agents in the management of periodontitis by inhibition of MMPs, inhibition of proinflammatory cytokines, inducible nitric oxide synthase (iNOS) and inhibition of bone resorption, enhancement of the attachment of fibroblasts and connective tissues to the tooth surface [Figure 6].[12]


Chemically modified tetracyclines: The novel host modulating agents.

Swamy DN, Sanivarapu S, Moogla S, Kapalavai V - J Indian Soc Periodontol (2015 Jul-Aug)

Schematic illustration of the pathogenesis of periodontitis, including targets for host modulation, depicting the action of CMTs on MMPs
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555791&req=5

Figure 6: Schematic illustration of the pathogenesis of periodontitis, including targets for host modulation, depicting the action of CMTs on MMPs
Mentions: CMTs are used as HMT agents in the management of periodontitis by inhibition of MMPs, inhibition of proinflammatory cytokines, inducible nitric oxide synthase (iNOS) and inhibition of bone resorption, enhancement of the attachment of fibroblasts and connective tissues to the tooth surface [Figure 6].[12]

Bottom Line: A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins.Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property.The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.

ABSTRACT
Periodontal pathogens and destructive host responses are involved in the initiation and progression of periodontitis. The emergence of host response modulation as a treatment concept has resulted from our improved understanding of the pathogenesis of periodontal disease. A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins. Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property. The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

No MeSH data available.


Related in: MedlinePlus