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Chemically modified tetracyclines: The novel host modulating agents.

Swamy DN, Sanivarapu S, Moogla S, Kapalavai V - J Indian Soc Periodontol (2015 Jul-Aug)

Bottom Line: A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins.Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property.The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.

ABSTRACT
Periodontal pathogens and destructive host responses are involved in the initiation and progression of periodontitis. The emergence of host response modulation as a treatment concept has resulted from our improved understanding of the pathogenesis of periodontal disease. A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins. Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property. The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

No MeSH data available.


Related in: MedlinePlus

Structure of CMT-2 and CMT-3
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Related In: Results  -  Collection

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Figure 3: Structure of CMT-2 and CMT-3


Chemically modified tetracyclines: The novel host modulating agents.

Swamy DN, Sanivarapu S, Moogla S, Kapalavai V - J Indian Soc Periodontol (2015 Jul-Aug)

Structure of CMT-2 and CMT-3
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555791&req=5

Figure 3: Structure of CMT-2 and CMT-3
Bottom Line: A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins.Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property.The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.

ABSTRACT
Periodontal pathogens and destructive host responses are involved in the initiation and progression of periodontitis. The emergence of host response modulation as a treatment concept has resulted from our improved understanding of the pathogenesis of periodontal disease. A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins. Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property. The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

No MeSH data available.


Related in: MedlinePlus