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Chemically modified tetracyclines: The novel host modulating agents.

Swamy DN, Sanivarapu S, Moogla S, Kapalavai V - J Indian Soc Periodontol (2015 Jul-Aug)

Bottom Line: A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins.Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property.The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.

ABSTRACT
Periodontal pathogens and destructive host responses are involved in the initiation and progression of periodontitis. The emergence of host response modulation as a treatment concept has resulted from our improved understanding of the pathogenesis of periodontal disease. A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins. Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property. The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

No MeSH data available.


Related in: MedlinePlus

Structure of tetracyclines
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Figure 1: Structure of tetracyclines

Mentions: Golub et al. discovered that the carbon 4 position side chain was responsible for the antimicrobial activity of tetracyclines [Figure 1]. CMTs were produced by removing the dimethylamino group from the carbon-4 position of the A ring of the four ringed (A, B, C, D) structure. The resulting compound, 4-dedimethylamino tetracycline (CMT-1) did not have antimicrobial property but the anti-collagenase activity was retained both in vitro and in vivo. Further modifications in the central structure of tetracyclines by addition or deletion of functional groups resulted in the formation of other CMTs. Currently, about 10 CMTs have been developed.


Chemically modified tetracyclines: The novel host modulating agents.

Swamy DN, Sanivarapu S, Moogla S, Kapalavai V - J Indian Soc Periodontol (2015 Jul-Aug)

Structure of tetracyclines
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555791&req=5

Figure 1: Structure of tetracyclines
Mentions: Golub et al. discovered that the carbon 4 position side chain was responsible for the antimicrobial activity of tetracyclines [Figure 1]. CMTs were produced by removing the dimethylamino group from the carbon-4 position of the A ring of the four ringed (A, B, C, D) structure. The resulting compound, 4-dedimethylamino tetracycline (CMT-1) did not have antimicrobial property but the anti-collagenase activity was retained both in vitro and in vivo. Further modifications in the central structure of tetracyclines by addition or deletion of functional groups resulted in the formation of other CMTs. Currently, about 10 CMTs have been developed.

Bottom Line: A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins.Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property.The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.

ABSTRACT
Periodontal pathogens and destructive host responses are involved in the initiation and progression of periodontitis. The emergence of host response modulation as a treatment concept has resulted from our improved understanding of the pathogenesis of periodontal disease. A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins. Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property. The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.

No MeSH data available.


Related in: MedlinePlus