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Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial.

Li P, Tjen-A-Looi SC, Cheng L, Liu D, Painovich J, Vinjamury S, Longhurst JC - Med Acupunct (2015)

Bottom Line: Objective: To examine effectiveness of electroacupuncture (EA) at select acupoints to reduce systolic blood pressure (SBP) and diastolic blood pressures (DBP) in hypertensive patients.Results: After 8 weeks, 33 patients treated with EA at PC 5-6+ST 36-37 had decreased peak and average SBP and DBP, compared with 32 patients treated with EA at LI 6-7+GB 37-39 control acupoints.Conclusions: EA at select acupoints reduces blood pressure.

View Article: PubMed Central - PubMed

Affiliation: Susan-Samueli Center for Integrative Medicine, University of California , Irvine, School of Medicine, Irvine, CA.

ABSTRACT

Background: Acupuncture at specific acupoints has experimentally been found to reduce chronically elevated blood pressure. Objective: To examine effectiveness of electroacupuncture (EA) at select acupoints to reduce systolic blood pressure (SBP) and diastolic blood pressures (DBP) in hypertensive patients. Design: Two-arm parallel study. Patients: Sixty-five hypertensive patients not receiving medication were assigned randomly to one of the two acupuncture intervention (33 versus 32 patients). Intervention: Patients were assessed with 24-hour ambulatory blood pressure monitoring. They were treated with 30-minutes of EA at PC 5-6+ST 36-37 or LI 6-7+GB 37-39 once weekly for 8 weeks. Four acupuncturists provided single-blinded treatment. Main outcome measures: Primary outcomes measuring effectiveness of EA were peak and average SBP and DBP. Secondary outcomes examined underlying mechanisms of acupuncture with plasma norepinephrine, renin, and aldosterone before and after 8 weeks of treatment. Outcomes were obtained by double-blinded evaluation. Results: After 8 weeks, 33 patients treated with EA at PC 5-6+ST 36-37 had decreased peak and average SBP and DBP, compared with 32 patients treated with EA at LI 6-7+GB 37-39 control acupoints. Changes in blood pressures significantly differed between the two patient groups. In 14 patients, a long-lasting blood pressure-lowering acupuncture effect was observed for an additional 4 weeks of EA at PC 5-6+ST 36-37. After treatment, the plasma concentration of norepinephrine, which was initially elevated, was decreased by 41%; likewise, renin was decreased by 67% and aldosterone by 22%. Conclusions: EA at select acupoints reduces blood pressure. Sympathetic and renin-aldosterone systems were likely related to the long-lasting EA actions.

No MeSH data available.


Related in: MedlinePlus

Group comparison of the changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) at 2, 4, 6, and 8 weeks with electroacupuncture (EA) treatment at active and control acupoints. The changes in SBP were different at week 8 in the two groups of patients with treatment at PC 5-6+ST 36-37 and LI 6-7+GB 36-37 (A). EA treatment at PC 5-6+ST 36-37 acupoints for 8 weeks decreased average DBP compared with control treatment (B).
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f6: Group comparison of the changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) at 2, 4, 6, and 8 weeks with electroacupuncture (EA) treatment at active and control acupoints. The changes in SBP were different at week 8 in the two groups of patients with treatment at PC 5-6+ST 36-37 and LI 6-7+GB 36-37 (A). EA treatment at PC 5-6+ST 36-37 acupoints for 8 weeks decreased average DBP compared with control treatment (B).

Mentions: Post hoc analyses demonstrated a significant difference in reduction of BP after 8 weeks of EA therapy at the active and control acupoints (Fig. 6). The difference in average SBP was 6.8 mmHg between groups by week 8. The change in average DBP was also different after 8 weeks of acupuncture.


Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial.

Li P, Tjen-A-Looi SC, Cheng L, Liu D, Painovich J, Vinjamury S, Longhurst JC - Med Acupunct (2015)

Group comparison of the changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) at 2, 4, 6, and 8 weeks with electroacupuncture (EA) treatment at active and control acupoints. The changes in SBP were different at week 8 in the two groups of patients with treatment at PC 5-6+ST 36-37 and LI 6-7+GB 36-37 (A). EA treatment at PC 5-6+ST 36-37 acupoints for 8 weeks decreased average DBP compared with control treatment (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555646&req=5

f6: Group comparison of the changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) at 2, 4, 6, and 8 weeks with electroacupuncture (EA) treatment at active and control acupoints. The changes in SBP were different at week 8 in the two groups of patients with treatment at PC 5-6+ST 36-37 and LI 6-7+GB 36-37 (A). EA treatment at PC 5-6+ST 36-37 acupoints for 8 weeks decreased average DBP compared with control treatment (B).
Mentions: Post hoc analyses demonstrated a significant difference in reduction of BP after 8 weeks of EA therapy at the active and control acupoints (Fig. 6). The difference in average SBP was 6.8 mmHg between groups by week 8. The change in average DBP was also different after 8 weeks of acupuncture.

Bottom Line: Objective: To examine effectiveness of electroacupuncture (EA) at select acupoints to reduce systolic blood pressure (SBP) and diastolic blood pressures (DBP) in hypertensive patients.Results: After 8 weeks, 33 patients treated with EA at PC 5-6+ST 36-37 had decreased peak and average SBP and DBP, compared with 32 patients treated with EA at LI 6-7+GB 37-39 control acupoints.Conclusions: EA at select acupoints reduces blood pressure.

View Article: PubMed Central - PubMed

Affiliation: Susan-Samueli Center for Integrative Medicine, University of California , Irvine, School of Medicine, Irvine, CA.

ABSTRACT

Background: Acupuncture at specific acupoints has experimentally been found to reduce chronically elevated blood pressure. Objective: To examine effectiveness of electroacupuncture (EA) at select acupoints to reduce systolic blood pressure (SBP) and diastolic blood pressures (DBP) in hypertensive patients. Design: Two-arm parallel study. Patients: Sixty-five hypertensive patients not receiving medication were assigned randomly to one of the two acupuncture intervention (33 versus 32 patients). Intervention: Patients were assessed with 24-hour ambulatory blood pressure monitoring. They were treated with 30-minutes of EA at PC 5-6+ST 36-37 or LI 6-7+GB 37-39 once weekly for 8 weeks. Four acupuncturists provided single-blinded treatment. Main outcome measures: Primary outcomes measuring effectiveness of EA were peak and average SBP and DBP. Secondary outcomes examined underlying mechanisms of acupuncture with plasma norepinephrine, renin, and aldosterone before and after 8 weeks of treatment. Outcomes were obtained by double-blinded evaluation. Results: After 8 weeks, 33 patients treated with EA at PC 5-6+ST 36-37 had decreased peak and average SBP and DBP, compared with 32 patients treated with EA at LI 6-7+GB 37-39 control acupoints. Changes in blood pressures significantly differed between the two patient groups. In 14 patients, a long-lasting blood pressure-lowering acupuncture effect was observed for an additional 4 weeks of EA at PC 5-6+ST 36-37. After treatment, the plasma concentration of norepinephrine, which was initially elevated, was decreased by 41%; likewise, renin was decreased by 67% and aldosterone by 22%. Conclusions: EA at select acupoints reduces blood pressure. Sympathetic and renin-aldosterone systems were likely related to the long-lasting EA actions.

No MeSH data available.


Related in: MedlinePlus