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Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma.

Lu J, Pan Y, Xia X, Gu Y, Lei Y - Biomed Res Int (2015)

Bottom Line: The Pearson correlation coefficient revealed a significant negative correlation in two proteins (correlation coefficient = -0.189, P < 0.005).The difference of survival rate between the two groups remained statistically significant. mTOR-low or PTEN-high patients had better 3-year rates of OS and DFS than mTOR-high or PTEN-low group (P < 0.001 by the log-rank test).This study also found that mTOR was an independence prognostic factor by multivariate analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

ABSTRACT
The prognostic value of mTOR in ESCC is much controversial; this study aimed to determine the prognostic importance of mTOR and PTEN in patients with ESCC. A total of 148 consecutive patients who underwent esophagectomy from 2010 to 2012 were included in this study, tested by western bolt and immunohistochemistry for mTOR and PTEN expression. Correlation coefficient was calculated using Pearson's correlation test. The 3-year overall survival (OS) and disease-free survival (DFS) were calculated in relation to the two markers. 94 (63.5%) of 148 were mTOR high expression, and PTEN high expression was detected in 46 (31.1%) of the 148 patients with ESCC. The Pearson correlation coefficient revealed a significant negative correlation in two proteins (correlation coefficient = -0.189, P < 0.005). The 3-year OS and DFS time in the mTOR-high group was 23.9 and 18.4 months, respectively, and the time in the mTOR-low group was 33.9 months and 31.4 months, respectively. The difference of survival rate between the two groups remained statistically significant. mTOR-low or PTEN-high patients had better 3-year rates of OS and DFS than mTOR-high or PTEN-low group (P < 0.001 by the log-rank test). This study also found that mTOR was an independence prognostic factor by multivariate analysis.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier estimates of survival among the study patients, according to tumor PTEN expression. For 3-year overall survival time (a) and 3-year progression-free survival time (b), PTEN expression was significantly associated with improved outcomes (P < 0.001; P < 0.001, resp.).
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fig5: Kaplan-Meier estimates of survival among the study patients, according to tumor PTEN expression. For 3-year overall survival time (a) and 3-year progression-free survival time (b), PTEN expression was significantly associated with improved outcomes (P < 0.001; P < 0.001, resp.).

Mentions: Based on Kaplan-Meier analysis, OS was superior in the PTEN-high expression group compared with that in the PTEN-low group, with 3-year survival time of 32.8 months and 25.2 months, respectively (P < 0.001; Figure 5(a)). PTEN-high patients also had statistically significantly better DFS than PTEN-low patients; the 3-year DFS were 29.7 months and 20.2 months, respectively (P < 0.001; Figure 5(b)). Using mTOR status as a stratification factor, the survival results were inversely correlated with the results based on PTEN expression. OS was superior in the mTOR-low group compared with that in the mTOR-high group, with 3-year survival time (33.9 months and 23.9 months, resp.; P < 0.001, Figure 6(a)). The low group also has longer DFS compared with high group. The 3-year DFS were 31.4 months and 18.4 months, respectively (P < 0.001, Figure 6(b)).


Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma.

Lu J, Pan Y, Xia X, Gu Y, Lei Y - Biomed Res Int (2015)

Kaplan-Meier estimates of survival among the study patients, according to tumor PTEN expression. For 3-year overall survival time (a) and 3-year progression-free survival time (b), PTEN expression was significantly associated with improved outcomes (P < 0.001; P < 0.001, resp.).
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Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4555449&req=5

fig5: Kaplan-Meier estimates of survival among the study patients, according to tumor PTEN expression. For 3-year overall survival time (a) and 3-year progression-free survival time (b), PTEN expression was significantly associated with improved outcomes (P < 0.001; P < 0.001, resp.).
Mentions: Based on Kaplan-Meier analysis, OS was superior in the PTEN-high expression group compared with that in the PTEN-low group, with 3-year survival time of 32.8 months and 25.2 months, respectively (P < 0.001; Figure 5(a)). PTEN-high patients also had statistically significantly better DFS than PTEN-low patients; the 3-year DFS were 29.7 months and 20.2 months, respectively (P < 0.001; Figure 5(b)). Using mTOR status as a stratification factor, the survival results were inversely correlated with the results based on PTEN expression. OS was superior in the mTOR-low group compared with that in the mTOR-high group, with 3-year survival time (33.9 months and 23.9 months, resp.; P < 0.001, Figure 6(a)). The low group also has longer DFS compared with high group. The 3-year DFS were 31.4 months and 18.4 months, respectively (P < 0.001, Figure 6(b)).

Bottom Line: The Pearson correlation coefficient revealed a significant negative correlation in two proteins (correlation coefficient = -0.189, P < 0.005).The difference of survival rate between the two groups remained statistically significant. mTOR-low or PTEN-high patients had better 3-year rates of OS and DFS than mTOR-high or PTEN-low group (P < 0.001 by the log-rank test).This study also found that mTOR was an independence prognostic factor by multivariate analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

ABSTRACT
The prognostic value of mTOR in ESCC is much controversial; this study aimed to determine the prognostic importance of mTOR and PTEN in patients with ESCC. A total of 148 consecutive patients who underwent esophagectomy from 2010 to 2012 were included in this study, tested by western bolt and immunohistochemistry for mTOR and PTEN expression. Correlation coefficient was calculated using Pearson's correlation test. The 3-year overall survival (OS) and disease-free survival (DFS) were calculated in relation to the two markers. 94 (63.5%) of 148 were mTOR high expression, and PTEN high expression was detected in 46 (31.1%) of the 148 patients with ESCC. The Pearson correlation coefficient revealed a significant negative correlation in two proteins (correlation coefficient = -0.189, P < 0.005). The 3-year OS and DFS time in the mTOR-high group was 23.9 and 18.4 months, respectively, and the time in the mTOR-low group was 33.9 months and 31.4 months, respectively. The difference of survival rate between the two groups remained statistically significant. mTOR-low or PTEN-high patients had better 3-year rates of OS and DFS than mTOR-high or PTEN-low group (P < 0.001 by the log-rank test). This study also found that mTOR was an independence prognostic factor by multivariate analysis.

No MeSH data available.


Related in: MedlinePlus