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The Application of Fluorescence Optical Imaging in Systemic Sclerosis.

Pfeil A, Drummer KF, Böttcher J, Jung C, Oelzner P, Renz DM, Franz M, Hansch A, Wolf G - Biomed Res Int (2015)

Bottom Line: After seven days of either iloprost or alprostadil therapy a significant reduction in the ICG was observed which ranged from 40.9% to 24.7%.The study demonstrates that the FOI technique is able to visualize soft-tissue inflammation with both high sensitivity and specificity.The anti-inflammatory therapeutic effects of iloprost were slightly stronger than alprostadil.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine III, Jena University Hospital, Friedrich Schiller University Jena, Erlanger Allee 101, 07747 Jena, Germany.

ABSTRACT

Objective: The aim of this study was to visualize soft tissue inflammation using FOI on patients with Systemic Sclerosis (SSc) characterized by SSc-related Raynaud's phenomenon and to detect the therapeutic response to treatment with iloprost or alprostadil.

Methods: Twenty-one patients with SSc and Raynaud's phenomenon and twenty-six healthy controls were prospectively included. The SSc patients were intravenously treated with iloprost or alprostadil over seven days. FOI was performed at baseline and after seven days using an intravenous application of indocyanine green (ICG). The hands were divided into nineteen segments per hand. All segments were quantitatively evaluated to determine changes in ICG.

Results: The sensitivity and specificity of FOI in the detection of ICG enhancement in patients with SSc were 95% versus 96%. At baseline, 31.5% hand segments showed ICG enhancement. After seven days of either iloprost or alprostadil therapy a significant reduction in the ICG was observed which ranged from 40.9% to 24.7%.

Conclusion: The study demonstrates that the FOI technique is able to visualize soft-tissue inflammation with both high sensitivity and specificity. The anti-inflammatory therapeutic effects of iloprost were slightly stronger than alprostadil. FOI offers promising benefits in the diagnosis and therapy of patients with SSc-associated Raynaud's phenomenon.

No MeSH data available.


Related in: MedlinePlus

Segments of both hands for quantification of inflammatory associated enhancement of indocyanine green in SSc (S = segment, MH = middle hand).
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fig1: Segments of both hands for quantification of inflammatory associated enhancement of indocyanine green in SSc (S = segment, MH = middle hand).

Mentions: All images were read in consensus by three observers to determine the ICG enhancement of both hands. Each hand was divided into 19 segments (see Figure 1). All 38 segments from both hands were analyzed and ICG fluorescence enhancement was determined per hand, and the total sum score from both hand segments was archived.


The Application of Fluorescence Optical Imaging in Systemic Sclerosis.

Pfeil A, Drummer KF, Böttcher J, Jung C, Oelzner P, Renz DM, Franz M, Hansch A, Wolf G - Biomed Res Int (2015)

Segments of both hands for quantification of inflammatory associated enhancement of indocyanine green in SSc (S = segment, MH = middle hand).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555360&req=5

fig1: Segments of both hands for quantification of inflammatory associated enhancement of indocyanine green in SSc (S = segment, MH = middle hand).
Mentions: All images were read in consensus by three observers to determine the ICG enhancement of both hands. Each hand was divided into 19 segments (see Figure 1). All 38 segments from both hands were analyzed and ICG fluorescence enhancement was determined per hand, and the total sum score from both hand segments was archived.

Bottom Line: After seven days of either iloprost or alprostadil therapy a significant reduction in the ICG was observed which ranged from 40.9% to 24.7%.The study demonstrates that the FOI technique is able to visualize soft-tissue inflammation with both high sensitivity and specificity.The anti-inflammatory therapeutic effects of iloprost were slightly stronger than alprostadil.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine III, Jena University Hospital, Friedrich Schiller University Jena, Erlanger Allee 101, 07747 Jena, Germany.

ABSTRACT

Objective: The aim of this study was to visualize soft tissue inflammation using FOI on patients with Systemic Sclerosis (SSc) characterized by SSc-related Raynaud's phenomenon and to detect the therapeutic response to treatment with iloprost or alprostadil.

Methods: Twenty-one patients with SSc and Raynaud's phenomenon and twenty-six healthy controls were prospectively included. The SSc patients were intravenously treated with iloprost or alprostadil over seven days. FOI was performed at baseline and after seven days using an intravenous application of indocyanine green (ICG). The hands were divided into nineteen segments per hand. All segments were quantitatively evaluated to determine changes in ICG.

Results: The sensitivity and specificity of FOI in the detection of ICG enhancement in patients with SSc were 95% versus 96%. At baseline, 31.5% hand segments showed ICG enhancement. After seven days of either iloprost or alprostadil therapy a significant reduction in the ICG was observed which ranged from 40.9% to 24.7%.

Conclusion: The study demonstrates that the FOI technique is able to visualize soft-tissue inflammation with both high sensitivity and specificity. The anti-inflammatory therapeutic effects of iloprost were slightly stronger than alprostadil. FOI offers promising benefits in the diagnosis and therapy of patients with SSc-associated Raynaud's phenomenon.

No MeSH data available.


Related in: MedlinePlus