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Multimodal imaging of a case of peripheral cone dystrophy.

Ito N, Kameya S, Gocho K, Hayashi T, Kikuchi S, Katagiri S, Gekka T, Yamaki K, Takahashi H, Tsuneoka H - Doc Ophthalmol (2015)

Bottom Line: Fluorescein and indocyanine green angiographies did not show any hyper- or hypofluorescent areas of the retina.The scotopic full-field ERGs were normal, but the photopic ERGs were markedly reduced.The parafoveal cone densities were severely decreased in both eyes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

ABSTRACT

Purpose: To characterize the peripheral cones in the images obtained by spectral-domain optical coherence tomography (OCT), swept source OCT, and adaptive optics fundus camera in a patient with peripheral cone dystrophy.

Methods: A 28-year-old Japanese man underwent detailed ophthalmic evaluations including high-resolution imaging of the fundus of both eyes.

Results: The decimal best-corrected visual acuity was 1.2 in both eyes. The results of slit-lamp biomicroscopy and ophthalmoscopy were essentially normal. Fluorescein and indocyanine green angiographies did not show any hyper- or hypofluorescent areas of the retina. Goldmann perimetry showed full peripheral visual fields but relative central scotomas within the central 20°. The results of the Humphrey Visual Field Analyzer showed a limited preservation of the central sensitivity. Color vision tests showed no errors in both eyes. Spectral-domain OCT showed attenuation of both the ellipsoid and interdigitation zones throughout the macular region except the center of the fovea. The scotopic full-field ERGs were normal, but the photopic ERGs were markedly reduced. Regular cone mosaics were not observed especially more than 450 μm radius from the fovea in the adaptive optics retinal images. The parafoveal cone densities were severely decreased in both eyes.

Conclusions: Our findings indicate that the peripheral cone dystrophy diagnosed by full-field ERGs and perimetry is due to a reduction in the density of parafoveal and peripheral cones.

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Related in: MedlinePlus

Visual fields of PCD patient. Results of Goldman kinetic perimetry (a, b) and pattern standard deviation of Humphrey Visual Field Analyzer (c, d) are shown. Results from the right eye (b, d) and left eye (a, c) are shown. Goldmann visual field tests show that the peripheral visual fields are full, but a relative central scotoma is present within 20° of the fovea in both eyes. Humphrey visual field testing (30-2) shows a relative central scotoma within 20° in right eye and 30° in left eye in the PCD patient. The central sensitivity is preserved locally in both eyes
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Fig2: Visual fields of PCD patient. Results of Goldman kinetic perimetry (a, b) and pattern standard deviation of Humphrey Visual Field Analyzer (c, d) are shown. Results from the right eye (b, d) and left eye (a, c) are shown. Goldmann visual field tests show that the peripheral visual fields are full, but a relative central scotoma is present within 20° of the fovea in both eyes. Humphrey visual field testing (30-2) shows a relative central scotoma within 20° in right eye and 30° in left eye in the PCD patient. The central sensitivity is preserved locally in both eyes

Mentions: Goldmann visual field tests showed that the peripheral visual fields were full, but a relative scotoma was found within 20° of the fovea in both eyes (Fig. 2a, b). The results of Humphrey Visual Field Analyzer with the central 30-2 SITA-standard program showed mean deviation (MD) values of −9.98 dB for the right eyes (P < 0.5 %) and −9.78 dB for the left eyes (P < 0.5 %). The pattern standard deviation (PSD) values were 5.21 dB for the right eye (P < 0.5 %) and 7.53 dB for the left eye (P < 0.5; Fig. 2c, d). The central sensitivity was not altered significantly in both eyes.Fig. 2


Multimodal imaging of a case of peripheral cone dystrophy.

Ito N, Kameya S, Gocho K, Hayashi T, Kikuchi S, Katagiri S, Gekka T, Yamaki K, Takahashi H, Tsuneoka H - Doc Ophthalmol (2015)

Visual fields of PCD patient. Results of Goldman kinetic perimetry (a, b) and pattern standard deviation of Humphrey Visual Field Analyzer (c, d) are shown. Results from the right eye (b, d) and left eye (a, c) are shown. Goldmann visual field tests show that the peripheral visual fields are full, but a relative central scotoma is present within 20° of the fovea in both eyes. Humphrey visual field testing (30-2) shows a relative central scotoma within 20° in right eye and 30° in left eye in the PCD patient. The central sensitivity is preserved locally in both eyes
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4555344&req=5

Fig2: Visual fields of PCD patient. Results of Goldman kinetic perimetry (a, b) and pattern standard deviation of Humphrey Visual Field Analyzer (c, d) are shown. Results from the right eye (b, d) and left eye (a, c) are shown. Goldmann visual field tests show that the peripheral visual fields are full, but a relative central scotoma is present within 20° of the fovea in both eyes. Humphrey visual field testing (30-2) shows a relative central scotoma within 20° in right eye and 30° in left eye in the PCD patient. The central sensitivity is preserved locally in both eyes
Mentions: Goldmann visual field tests showed that the peripheral visual fields were full, but a relative scotoma was found within 20° of the fovea in both eyes (Fig. 2a, b). The results of Humphrey Visual Field Analyzer with the central 30-2 SITA-standard program showed mean deviation (MD) values of −9.98 dB for the right eyes (P < 0.5 %) and −9.78 dB for the left eyes (P < 0.5 %). The pattern standard deviation (PSD) values were 5.21 dB for the right eye (P < 0.5 %) and 7.53 dB for the left eye (P < 0.5; Fig. 2c, d). The central sensitivity was not altered significantly in both eyes.Fig. 2

Bottom Line: Fluorescein and indocyanine green angiographies did not show any hyper- or hypofluorescent areas of the retina.The scotopic full-field ERGs were normal, but the photopic ERGs were markedly reduced.The parafoveal cone densities were severely decreased in both eyes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

ABSTRACT

Purpose: To characterize the peripheral cones in the images obtained by spectral-domain optical coherence tomography (OCT), swept source OCT, and adaptive optics fundus camera in a patient with peripheral cone dystrophy.

Methods: A 28-year-old Japanese man underwent detailed ophthalmic evaluations including high-resolution imaging of the fundus of both eyes.

Results: The decimal best-corrected visual acuity was 1.2 in both eyes. The results of slit-lamp biomicroscopy and ophthalmoscopy were essentially normal. Fluorescein and indocyanine green angiographies did not show any hyper- or hypofluorescent areas of the retina. Goldmann perimetry showed full peripheral visual fields but relative central scotomas within the central 20°. The results of the Humphrey Visual Field Analyzer showed a limited preservation of the central sensitivity. Color vision tests showed no errors in both eyes. Spectral-domain OCT showed attenuation of both the ellipsoid and interdigitation zones throughout the macular region except the center of the fovea. The scotopic full-field ERGs were normal, but the photopic ERGs were markedly reduced. Regular cone mosaics were not observed especially more than 450 μm radius from the fovea in the adaptive optics retinal images. The parafoveal cone densities were severely decreased in both eyes.

Conclusions: Our findings indicate that the peripheral cone dystrophy diagnosed by full-field ERGs and perimetry is due to a reduction in the density of parafoveal and peripheral cones.

Show MeSH
Related in: MedlinePlus