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Additional Burden of Diseases Associated with Cadmium Exposure: A Case Study of Cadmium Contaminated Rice Fields in Mae Sot District, Tak Province, Thailand.

Songprasert N, Sukaew T, Kusreesakul K, Swaddiwudhipong W, Padungtod C, Bundhamcharoen K - Int J Environ Res Public Health (2015)

Bottom Line: The ceiling effect was observed in results using dietary Cd intake because of the high Cd content in rice grown in the Mae Sot area.The results from β2-MG were more robust with additional DALYs ranging from 36%-86% for heart failure, cerebral infraction, and nephrosis/nephritis.The Mae Sot population lost more healthy life compared to populations living in a non- or less Cd polluted area.

View Article: PubMed Central - PubMed

Affiliation: International Health Policy Program, Ministry of Public Health, Nonthaburi 11000, Thailand. nisarat@ihpp.thaigov.net.

ABSTRACT
The cadmium (Cd) contaminated rice fields in Mae Sot District, Tak Province, Thailand has been one of the major environmental problems in Thailand for the last 10 years. We used disability adjusted life years (DALYs) to estimate the burden of disease attributable to Cd in terms of additional DALYs of Mae Sot residents. Cd exposure data included Cd and β2-microglobulin (β2-MG) in urine (as an internal exposure dose) and estimated cadmium daily intake (as an external exposure dose). Compared to the general Thai population, Mae Sot residents gained 10%-86% DALYs from nephrosis/nephritis, heart diseases, osteoporosis and cancer depending on their Cd exposure type and exposure level. The results for urinary Cd and dietary Cd intake varied according to the studies used for risk estimation. The ceiling effect was observed in results using dietary Cd intake because of the high Cd content in rice grown in the Mae Sot area. The results from β2-MG were more robust with additional DALYs ranging from 36%-86% for heart failure, cerebral infraction, and nephrosis/nephritis. Additional DALYs is a useful approach for assessing the magnitude of environmental Cd exposure. The Mae Sot population lost more healthy life compared to populations living in a non- or less Cd polluted area. This method should be applicable to various types of environmental contamination problems if exposure assessment information is available.

No MeSH data available.


Related in: MedlinePlus

Distribution of β2–microglobulin (β2-MG) in surveyed population in Mae Sot areas: residents in Mae Ku (mean = 150 µg/g creatinine, 95% CI = 108–194), Mae Tao (mean = 264 µg/g creatinine, 95% CI = 199–328), and Pra Tad Pha Dang (mean = 201 µg/g creatinine, 95% CI = 146–257).
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ijerph-12-09199-f002: Distribution of β2–microglobulin (β2-MG) in surveyed population in Mae Sot areas: residents in Mae Ku (mean = 150 µg/g creatinine, 95% CI = 108–194), Mae Tao (mean = 264 µg/g creatinine, 95% CI = 199–328), and Pra Tad Pha Dang (mean = 201 µg/g creatinine, 95% CI = 146–257).

Mentions: The β2-MG data was obtained from the subset of U-Cd survey in 2004 [13], which included 480 residents with U-Cd exceeding 5 µg/g creatinine. Figure 2 shows the distribution of β2-MG level across the population in the study: from Mae Ku (n = 75), Mae Tao (n = 283) and Phra Tad Pha Dang (n = 122). The body burden of β2-MG in these inhabitants ranged from 2.17–146,129 µg/g creatinine, and approximately 60% of this surveyed population exhibited β2-MG concentration over 300 µg/g creatinine.


Additional Burden of Diseases Associated with Cadmium Exposure: A Case Study of Cadmium Contaminated Rice Fields in Mae Sot District, Tak Province, Thailand.

Songprasert N, Sukaew T, Kusreesakul K, Swaddiwudhipong W, Padungtod C, Bundhamcharoen K - Int J Environ Res Public Health (2015)

Distribution of β2–microglobulin (β2-MG) in surveyed population in Mae Sot areas: residents in Mae Ku (mean = 150 µg/g creatinine, 95% CI = 108–194), Mae Tao (mean = 264 µg/g creatinine, 95% CI = 199–328), and Pra Tad Pha Dang (mean = 201 µg/g creatinine, 95% CI = 146–257).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555274&req=5

ijerph-12-09199-f002: Distribution of β2–microglobulin (β2-MG) in surveyed population in Mae Sot areas: residents in Mae Ku (mean = 150 µg/g creatinine, 95% CI = 108–194), Mae Tao (mean = 264 µg/g creatinine, 95% CI = 199–328), and Pra Tad Pha Dang (mean = 201 µg/g creatinine, 95% CI = 146–257).
Mentions: The β2-MG data was obtained from the subset of U-Cd survey in 2004 [13], which included 480 residents with U-Cd exceeding 5 µg/g creatinine. Figure 2 shows the distribution of β2-MG level across the population in the study: from Mae Ku (n = 75), Mae Tao (n = 283) and Phra Tad Pha Dang (n = 122). The body burden of β2-MG in these inhabitants ranged from 2.17–146,129 µg/g creatinine, and approximately 60% of this surveyed population exhibited β2-MG concentration over 300 µg/g creatinine.

Bottom Line: The ceiling effect was observed in results using dietary Cd intake because of the high Cd content in rice grown in the Mae Sot area.The results from β2-MG were more robust with additional DALYs ranging from 36%-86% for heart failure, cerebral infraction, and nephrosis/nephritis.The Mae Sot population lost more healthy life compared to populations living in a non- or less Cd polluted area.

View Article: PubMed Central - PubMed

Affiliation: International Health Policy Program, Ministry of Public Health, Nonthaburi 11000, Thailand. nisarat@ihpp.thaigov.net.

ABSTRACT
The cadmium (Cd) contaminated rice fields in Mae Sot District, Tak Province, Thailand has been one of the major environmental problems in Thailand for the last 10 years. We used disability adjusted life years (DALYs) to estimate the burden of disease attributable to Cd in terms of additional DALYs of Mae Sot residents. Cd exposure data included Cd and β2-microglobulin (β2-MG) in urine (as an internal exposure dose) and estimated cadmium daily intake (as an external exposure dose). Compared to the general Thai population, Mae Sot residents gained 10%-86% DALYs from nephrosis/nephritis, heart diseases, osteoporosis and cancer depending on their Cd exposure type and exposure level. The results for urinary Cd and dietary Cd intake varied according to the studies used for risk estimation. The ceiling effect was observed in results using dietary Cd intake because of the high Cd content in rice grown in the Mae Sot area. The results from β2-MG were more robust with additional DALYs ranging from 36%-86% for heart failure, cerebral infraction, and nephrosis/nephritis. Additional DALYs is a useful approach for assessing the magnitude of environmental Cd exposure. The Mae Sot population lost more healthy life compared to populations living in a non- or less Cd polluted area. This method should be applicable to various types of environmental contamination problems if exposure assessment information is available.

No MeSH data available.


Related in: MedlinePlus