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Chronic Exposure to Static Magnetic Fields from Magnetic Resonance Imaging Devices Deserves Screening for Osteoporosis and Vitamin D Levels: A Rat Model.

Gungor HR, Akkaya S, Ok N, Yorukoglu A, Yorukoglu C, Kiter E, Oguz EO, Keskin N, Mete GA - Int J Environ Res Public Health (2015)

Bottom Line: The mean vitamin D level in Group A was lower than in the other groups (p = 0.002).The mean cortical thickness, the mean trabecular wall thickness, and number of trabeculae per 1 mm2 were significantly lower in Group A (p = 0.003).TUNEL assay revealed that apoptosis of osteocytes were significantly greater in Group A than the other groups (p = 0.005).

View Article: PubMed Central - PubMed

Affiliation: Orthopedics and Traumatology Department, Pamukkale University Medical Faculty, Denizli 20070, Turkey. hrgungor@gmail.com.

ABSTRACT
Technicians often receive chronic magnetic exposures from magnetic resonance imaging (MRI) devices, mainly due to static magnetic fields (SMFs). Here, we ascertain the biological effects of chronic exposure to SMFs from MRI devices on the bone quality using rats exposed to SMFs in MRI examining rooms. Eighteen Wistar albino male rats were randomly assigned to SMF exposure (A), sham (B), and control (C) groups. Group A rats were positioned within 50 centimeters of the bore of the magnet of 1.5 T MRI machine during the nighttime for 8 weeks. We collected blood samples for biochemical analysis, and bone tissue samples for electron microscopic and histological analysis. The mean vitamin D level in Group A was lower than in the other groups (p = 0.002). The mean cortical thickness, the mean trabecular wall thickness, and number of trabeculae per 1 mm2 were significantly lower in Group A (p = 0.003). TUNEL assay revealed that apoptosis of osteocytes were significantly greater in Group A than the other groups (p = 0.005). The effect of SMFs in chronic exposure is related to movement within the magnetic field that induces low-frequency fields within the tissues. These fields can exceed the exposure limits necessary to deteriorate bone microstructure and vitamin D metabolism.

No MeSH data available.


Related in: MedlinePlus

Measurement of trabecular bone thickness and determination of number of trabeculae (on a chart area of approximately 878 × 1250 µm2 at 4× magnification) on the histologic specimen (specimen from Group A).
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ijerph-12-08919-f002: Measurement of trabecular bone thickness and determination of number of trabeculae (on a chart area of approximately 878 × 1250 µm2 at 4× magnification) on the histologic specimen (specimen from Group A).

Mentions: Number of trabeculae in each cross section of histogical specimen counted on a chart area of approximately 878 × 1250 µm2 at 4× magnification (Figure 2). The average number of trabeculae per 1 mm2 area was calculated for each rat (number of trabeculae in 1 mm2 / number of cross sectional specimen for each rat). Thickness of each trabeculae was measured in designated area of each slice of the specimen using the software of the computer that the measurements were done, and average thickness of the measured trabecular width was assigned for evaluation of the specific specimen (sum of the thickness of the trabeculae on each slice of specimen / total number of trabeculae on each slice of specimen).


Chronic Exposure to Static Magnetic Fields from Magnetic Resonance Imaging Devices Deserves Screening for Osteoporosis and Vitamin D Levels: A Rat Model.

Gungor HR, Akkaya S, Ok N, Yorukoglu A, Yorukoglu C, Kiter E, Oguz EO, Keskin N, Mete GA - Int J Environ Res Public Health (2015)

Measurement of trabecular bone thickness and determination of number of trabeculae (on a chart area of approximately 878 × 1250 µm2 at 4× magnification) on the histologic specimen (specimen from Group A).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555256&req=5

ijerph-12-08919-f002: Measurement of trabecular bone thickness and determination of number of trabeculae (on a chart area of approximately 878 × 1250 µm2 at 4× magnification) on the histologic specimen (specimen from Group A).
Mentions: Number of trabeculae in each cross section of histogical specimen counted on a chart area of approximately 878 × 1250 µm2 at 4× magnification (Figure 2). The average number of trabeculae per 1 mm2 area was calculated for each rat (number of trabeculae in 1 mm2 / number of cross sectional specimen for each rat). Thickness of each trabeculae was measured in designated area of each slice of the specimen using the software of the computer that the measurements were done, and average thickness of the measured trabecular width was assigned for evaluation of the specific specimen (sum of the thickness of the trabeculae on each slice of specimen / total number of trabeculae on each slice of specimen).

Bottom Line: The mean vitamin D level in Group A was lower than in the other groups (p = 0.002).The mean cortical thickness, the mean trabecular wall thickness, and number of trabeculae per 1 mm2 were significantly lower in Group A (p = 0.003).TUNEL assay revealed that apoptosis of osteocytes were significantly greater in Group A than the other groups (p = 0.005).

View Article: PubMed Central - PubMed

Affiliation: Orthopedics and Traumatology Department, Pamukkale University Medical Faculty, Denizli 20070, Turkey. hrgungor@gmail.com.

ABSTRACT
Technicians often receive chronic magnetic exposures from magnetic resonance imaging (MRI) devices, mainly due to static magnetic fields (SMFs). Here, we ascertain the biological effects of chronic exposure to SMFs from MRI devices on the bone quality using rats exposed to SMFs in MRI examining rooms. Eighteen Wistar albino male rats were randomly assigned to SMF exposure (A), sham (B), and control (C) groups. Group A rats were positioned within 50 centimeters of the bore of the magnet of 1.5 T MRI machine during the nighttime for 8 weeks. We collected blood samples for biochemical analysis, and bone tissue samples for electron microscopic and histological analysis. The mean vitamin D level in Group A was lower than in the other groups (p = 0.002). The mean cortical thickness, the mean trabecular wall thickness, and number of trabeculae per 1 mm2 were significantly lower in Group A (p = 0.003). TUNEL assay revealed that apoptosis of osteocytes were significantly greater in Group A than the other groups (p = 0.005). The effect of SMFs in chronic exposure is related to movement within the magnetic field that induces low-frequency fields within the tissues. These fields can exceed the exposure limits necessary to deteriorate bone microstructure and vitamin D metabolism.

No MeSH data available.


Related in: MedlinePlus