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CA-SSR1 Polymorphism in Intron 1 of the EGFR Gene in Patients with Malignant Tumors Who Develop Acneiform Rash Associated with the Use of Cetuximab.

Jarząbek T, Rucińska M, Rogowski W, Lewandowska M, Tujakowski J, Habib M, Kowalczyk A, Byszek A, Dziadziuszko R, Nawrocki S - Mol Diagn Ther (2015)

Bottom Line: The study included 60 patients treated with cetuximab.The cutoffs S≤17(CA), L>17(CA), n(CA)≤35, and n(CA)>35 were tested, as well as the sum of the two allele repetitions.No statistically significant relationship between genotype and response to treatment was observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, University of Warmia and Mazury, Olsztyn, Poland.

ABSTRACT

Background and objective: Epidermal growth factor receptor (EGFR) inhibitors are not equally effective in all cancer patients. One potential clinical factor that could help in selecting patients who may benefit from treatment with cetuximab is acneiform rash, which correlates with the clinical response to EGFR inhibitors. Some previous studies have suggested that the tendency to develop rash may depend on polymorphisms in the EGFR gene. In this investigation, the association of degree of CA dinucleotide polymorphism with skin rash and cetuximab therapy outcome was examined.

Methods: The study included 60 patients treated with cetuximab. For each patient, the severity of acneiform rash was assessed, and the type of polymorphism was determined by genotyping. Associations between genotypes, the acneiform rash, and response to treatment were determined by using the chi-square test and Spearman's rank correlation. The cutoffs S≤17(CA), L>17(CA), n(CA)≤35, and n(CA)>35 were tested, as well as the sum of the two allele repetitions.

Results: A correlation was found between body surface area covered by rash and the sum of the two allele repetitions (p=0.030). No statistically significant relationship between genotype and response to treatment was observed. However, in patients who have had partial remission, we noticed a higher incidence of polymorphism, with less CA dinucleotide repetitions and early onset of rash.

Conclusion: A correlation between genotype and severity of rash was observed. That is, the severity of rash decreased with an increased number of CA repetitions.

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Related in: MedlinePlus

Examination of the relationship between the rash and CA-SSR1 polymorphism of the EGFR gene. Scatterplot of total repetitions two alleles CA-SSR1 vs. body surface area covered by acneiform rash. CA-SSR1 CA simple sequence repeat in intron 1, EGFR epidermal growth factor receptor
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Related In: Results  -  Collection


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Fig2: Examination of the relationship between the rash and CA-SSR1 polymorphism of the EGFR gene. Scatterplot of total repetitions two alleles CA-SSR1 vs. body surface area covered by acneiform rash. CA-SSR1 CA simple sequence repeat in intron 1, EGFR epidermal growth factor receptor

Mentions: Examination of the relationship between the acneiform rash and CA simple sequence repeat in intron 1 (CA-SSR1) polymorphism of the epidermal growth factor receptor (EGFR) gene


CA-SSR1 Polymorphism in Intron 1 of the EGFR Gene in Patients with Malignant Tumors Who Develop Acneiform Rash Associated with the Use of Cetuximab.

Jarząbek T, Rucińska M, Rogowski W, Lewandowska M, Tujakowski J, Habib M, Kowalczyk A, Byszek A, Dziadziuszko R, Nawrocki S - Mol Diagn Ther (2015)

Examination of the relationship between the rash and CA-SSR1 polymorphism of the EGFR gene. Scatterplot of total repetitions two alleles CA-SSR1 vs. body surface area covered by acneiform rash. CA-SSR1 CA simple sequence repeat in intron 1, EGFR epidermal growth factor receptor
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4555232&req=5

Fig2: Examination of the relationship between the rash and CA-SSR1 polymorphism of the EGFR gene. Scatterplot of total repetitions two alleles CA-SSR1 vs. body surface area covered by acneiform rash. CA-SSR1 CA simple sequence repeat in intron 1, EGFR epidermal growth factor receptor
Mentions: Examination of the relationship between the acneiform rash and CA simple sequence repeat in intron 1 (CA-SSR1) polymorphism of the epidermal growth factor receptor (EGFR) gene

Bottom Line: The study included 60 patients treated with cetuximab.The cutoffs S≤17(CA), L>17(CA), n(CA)≤35, and n(CA)>35 were tested, as well as the sum of the two allele repetitions.No statistically significant relationship between genotype and response to treatment was observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, University of Warmia and Mazury, Olsztyn, Poland.

ABSTRACT

Background and objective: Epidermal growth factor receptor (EGFR) inhibitors are not equally effective in all cancer patients. One potential clinical factor that could help in selecting patients who may benefit from treatment with cetuximab is acneiform rash, which correlates with the clinical response to EGFR inhibitors. Some previous studies have suggested that the tendency to develop rash may depend on polymorphisms in the EGFR gene. In this investigation, the association of degree of CA dinucleotide polymorphism with skin rash and cetuximab therapy outcome was examined.

Methods: The study included 60 patients treated with cetuximab. For each patient, the severity of acneiform rash was assessed, and the type of polymorphism was determined by genotyping. Associations between genotypes, the acneiform rash, and response to treatment were determined by using the chi-square test and Spearman's rank correlation. The cutoffs S≤17(CA), L>17(CA), n(CA)≤35, and n(CA)>35 were tested, as well as the sum of the two allele repetitions.

Results: A correlation was found between body surface area covered by rash and the sum of the two allele repetitions (p=0.030). No statistically significant relationship between genotype and response to treatment was observed. However, in patients who have had partial remission, we noticed a higher incidence of polymorphism, with less CA dinucleotide repetitions and early onset of rash.

Conclusion: A correlation between genotype and severity of rash was observed. That is, the severity of rash decreased with an increased number of CA repetitions.

Show MeSH
Related in: MedlinePlus