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The Placental Microbiome Varies in Association with Low Birth Weight in Full-Term Neonates.

Zheng J, Xiao X, Zhang Q, Mao L, Yu M, Xu J - Nutrients (2015)

Bottom Line: There were significant variations in the composition of placenta microbiota between the LBW and NBW neonates at the phylum and genus level.Furthermore, it indicated that Lactobacillus percentage was positively associated with birth weight (r = 0.541, p = 0.025).In conclusion, our present study for the first time detected the relationship between birth weight and placental microbiome profile in full-term neonates.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. zhengjiapumc@163.com.

ABSTRACT
Substantial evidence indicated that low birth weight was an independent risk factor for obesity, impaired glucose regulation, and diabetes later in life. However, investigations into the association between low birth weight and placental microbiome in full-term neonates are limited. Placentas were collected from low birth weight (LBW) and normal birth weight (NBW) full-term neonates (gestational age 37 w0d-41 w6d) consecutively born at Peking Union Medical College Hospital. The anthropometric measurements were measured and 16S ribosomal DNAamplicon high-throughput sequencing were utilized to define bacteria within placenta tissues. It showed that birth weight, ponderal index, head circumference, and placenta weight were significantly lower in LBW than NBW neonates (p < 0.05). The operational taxonomic units (OTUs) (p < 0.05) and the estimators of community richness (Chao) indexes (p < 0.05) showed a significantly lower diversity in LBW than NBW neonates. There were significant variations in the composition of placenta microbiota between the LBW and NBW neonates at the phylum and genus level. Furthermore, it indicated that Lactobacillus percentage was positively associated with birth weight (r = 0.541, p = 0.025). In conclusion, our present study for the first time detected the relationship between birth weight and placental microbiome profile in full-term neonates. It is novel in showing that the placental microbiome varies in association with low birth weight in full-term neonates.

No MeSH data available.


Related in: MedlinePlus

Relative abundance (%) of placenta microbiota in each sample at the genus level. n = 12, in each group. Abbreviations: LBW, Low birth weight; NBW, Normal birth weight.
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nutrients-07-05315-f002: Relative abundance (%) of placenta microbiota in each sample at the genus level. n = 12, in each group. Abbreviations: LBW, Low birth weight; NBW, Normal birth weight.

Mentions: Figure 2 shows relative abundance (%) of placenta microbiota in each sample at the genus level. The overall microbiota structure for each group at the phylum and genus level is shown in Figure 3. At the phylum level, the dominant phylum of the two groups was Firmicutes. The relative abundance (%) of Firmicutes was decreased in LBW group, while Proteobacteria and Actinobacteria were increased in LBW group, compared with NBW group. At the genus level, the dominant phylum of the two groups was Enterococcus. The relative abundance (%) of Enterococcus was decreased in LBW group, while Lactococcus and Bacillus were increased in LBW group, compared with NBW group. The relative abundance of microbiota sequences revealed that microbial structures of the placenta differed significantly between LBW and NBW groups. The heatmap according to bacterial genus level also demonstrated the same phenomenon (Figure 4).


The Placental Microbiome Varies in Association with Low Birth Weight in Full-Term Neonates.

Zheng J, Xiao X, Zhang Q, Mao L, Yu M, Xu J - Nutrients (2015)

Relative abundance (%) of placenta microbiota in each sample at the genus level. n = 12, in each group. Abbreviations: LBW, Low birth weight; NBW, Normal birth weight.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555154&req=5

nutrients-07-05315-f002: Relative abundance (%) of placenta microbiota in each sample at the genus level. n = 12, in each group. Abbreviations: LBW, Low birth weight; NBW, Normal birth weight.
Mentions: Figure 2 shows relative abundance (%) of placenta microbiota in each sample at the genus level. The overall microbiota structure for each group at the phylum and genus level is shown in Figure 3. At the phylum level, the dominant phylum of the two groups was Firmicutes. The relative abundance (%) of Firmicutes was decreased in LBW group, while Proteobacteria and Actinobacteria were increased in LBW group, compared with NBW group. At the genus level, the dominant phylum of the two groups was Enterococcus. The relative abundance (%) of Enterococcus was decreased in LBW group, while Lactococcus and Bacillus were increased in LBW group, compared with NBW group. The relative abundance of microbiota sequences revealed that microbial structures of the placenta differed significantly between LBW and NBW groups. The heatmap according to bacterial genus level also demonstrated the same phenomenon (Figure 4).

Bottom Line: There were significant variations in the composition of placenta microbiota between the LBW and NBW neonates at the phylum and genus level.Furthermore, it indicated that Lactobacillus percentage was positively associated with birth weight (r = 0.541, p = 0.025).In conclusion, our present study for the first time detected the relationship between birth weight and placental microbiome profile in full-term neonates.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. zhengjiapumc@163.com.

ABSTRACT
Substantial evidence indicated that low birth weight was an independent risk factor for obesity, impaired glucose regulation, and diabetes later in life. However, investigations into the association between low birth weight and placental microbiome in full-term neonates are limited. Placentas were collected from low birth weight (LBW) and normal birth weight (NBW) full-term neonates (gestational age 37 w0d-41 w6d) consecutively born at Peking Union Medical College Hospital. The anthropometric measurements were measured and 16S ribosomal DNAamplicon high-throughput sequencing were utilized to define bacteria within placenta tissues. It showed that birth weight, ponderal index, head circumference, and placenta weight were significantly lower in LBW than NBW neonates (p < 0.05). The operational taxonomic units (OTUs) (p < 0.05) and the estimators of community richness (Chao) indexes (p < 0.05) showed a significantly lower diversity in LBW than NBW neonates. There were significant variations in the composition of placenta microbiota between the LBW and NBW neonates at the phylum and genus level. Furthermore, it indicated that Lactobacillus percentage was positively associated with birth weight (r = 0.541, p = 0.025). In conclusion, our present study for the first time detected the relationship between birth weight and placental microbiome profile in full-term neonates. It is novel in showing that the placental microbiome varies in association with low birth weight in full-term neonates.

No MeSH data available.


Related in: MedlinePlus