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Role of MicroRNAs-221/222 in Digestive Systems.

Matsuzaki J, Suzuki H - J Clin Med (2015)

Bottom Line: MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors, such as esophageal adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma.On the other hand, miR-221/222 also play onco-suppressive roles in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs).Here we will review the roles of miR-221/222 in digestive systems and their possibility as prognostic and therapeutic tools.

View Article: PubMed Central - PubMed

Affiliation: Center for Preventive Medicine, Keio University Hospital, Tokyo 160-0016, Japan. juntaro.matsuzaki@gmail.com.

ABSTRACT
MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors, such as esophageal adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma. In these cancers, silencing miR-221/222 could represent a novel anti-tumor approach to inhibit tumor growth and metastasis. On the other hand, miR-221/222 also play onco-suppressive roles in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs). Here we will review the roles of miR-221/222 in digestive systems and their possibility as prognostic and therapeutic tools.

No MeSH data available.


Related in: MedlinePlus

A schematic of the regulatory mechanisms of miR-221/222 in hepatocarcinogenesis.
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jcm-04-01566-f001: A schematic of the regulatory mechanisms of miR-221/222 in hepatocarcinogenesis.

Mentions: In HCC cells or hepatocyte, various functions of miR-221/222 have been investigated (Figure 1). In addition to p27Kip1 and p57Kip2, several direct targets of miR-221/222 were identified, such as estrogen receptor-alpha (ERα) and a proapoptotic BH3-only protein (BMF) [33,34]. DNA damage-inducible transcript 4 (DDIT4), a modulator of mTOR pathway, was also a direct target of miR-221 [30]. Garofalo et al. showed that miR-221/222, by targeting PTEN and TIMP3 tumor suppressors, induce TRAIL resistance and enhance cellular migration through the activation of the AKT pathway and metallopeptidases. Xu et al. reported that miR-221 was upregulated by HCV infection [35]. In addition, an miR-221 mimic could accentuate the anti-HCV effect of IFN-α in an HCV model, through the inhibition of two members of the suppressor of cytokine signaling (SOCS) family, SOCS1 and SOCS3.


Role of MicroRNAs-221/222 in Digestive Systems.

Matsuzaki J, Suzuki H - J Clin Med (2015)

A schematic of the regulatory mechanisms of miR-221/222 in hepatocarcinogenesis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555077&req=5

jcm-04-01566-f001: A schematic of the regulatory mechanisms of miR-221/222 in hepatocarcinogenesis.
Mentions: In HCC cells or hepatocyte, various functions of miR-221/222 have been investigated (Figure 1). In addition to p27Kip1 and p57Kip2, several direct targets of miR-221/222 were identified, such as estrogen receptor-alpha (ERα) and a proapoptotic BH3-only protein (BMF) [33,34]. DNA damage-inducible transcript 4 (DDIT4), a modulator of mTOR pathway, was also a direct target of miR-221 [30]. Garofalo et al. showed that miR-221/222, by targeting PTEN and TIMP3 tumor suppressors, induce TRAIL resistance and enhance cellular migration through the activation of the AKT pathway and metallopeptidases. Xu et al. reported that miR-221 was upregulated by HCV infection [35]. In addition, an miR-221 mimic could accentuate the anti-HCV effect of IFN-α in an HCV model, through the inhibition of two members of the suppressor of cytokine signaling (SOCS) family, SOCS1 and SOCS3.

Bottom Line: MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors, such as esophageal adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma.On the other hand, miR-221/222 also play onco-suppressive roles in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs).Here we will review the roles of miR-221/222 in digestive systems and their possibility as prognostic and therapeutic tools.

View Article: PubMed Central - PubMed

Affiliation: Center for Preventive Medicine, Keio University Hospital, Tokyo 160-0016, Japan. juntaro.matsuzaki@gmail.com.

ABSTRACT
MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors, such as esophageal adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma. In these cancers, silencing miR-221/222 could represent a novel anti-tumor approach to inhibit tumor growth and metastasis. On the other hand, miR-221/222 also play onco-suppressive roles in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs). Here we will review the roles of miR-221/222 in digestive systems and their possibility as prognostic and therapeutic tools.

No MeSH data available.


Related in: MedlinePlus