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Calibrated integrated backscatter and myocardial fibrosis in patients undergoing cardiac surgery.

Prior DL, Somaratne JB, Jenkins AJ, Yii M, Newcomb AE, Schalkwijk CG, Black MJ, Kelly DJ, Campbell DJ - Open Heart (2015)

Bottom Line: However, cIB was not significantly associated with other histological parameters, including immunostaining for collagens I and III, the advanced glycation end product (AGE) N(ε)-(carboxymethyl)lysine (CML) and the receptor for AGEs (RAGE).When biomarkers were examined, cIB was weakly associated with log plasma levels of amino-terminal pro-B-type natriuretic peptide (r=0.34, p=0.03), creatinine (r=0.33, p=0.04) and glomerular filtration rate (r=-0.33, p=0.04), and was more strongly associated with log plasma levels of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) (r=0.44, p=0.01) and soluble RAGE (r=0.53, p=0.002).Higher cIB was not a marker of increased myocardial fibrosis in patients with coronary artery disease, but was associated with higher plasma levels of sVEGFR-1 and soluble RAGE.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology , St. Vincent's Hospital Melbourne , Fitzroy , Australia ; Department of Medicine , University of Melbourne, St. Vincent's Hospital Melbourne , Fitzroy , Australia ; St. Vincent's Institute of Medical Research , Fitzroy , Australia.

ABSTRACT

Objective: The reported association between calibrated integrated backscatter (cIB) and myocardial fibrosis is based on study of patients with dilated or hypertrophic cardiomyopathy and extensive (mean 15-34%) fibrosis. Its association with lesser degrees of fibrosis is unknown. We examined the relationship between cIB and myocardial fibrosis in patients with coronary artery disease.

Methods: Myocardial histology was examined in left ventricular epicardial biopsies from 40 patients (29 men and 11 women) undergoing coronary artery bypass graft surgery, who had preoperative echocardiography with cIB measurement.

Results: Total fibrosis (picrosirius red staining) varied from 0.7% to 4%, and in contrast to previous reports, cIB showed weak inverse associations with total fibrosis (r=-0.32, p=0.047) and interstitial fibrosis (r=-0.34, p=0.03). However, cIB was not significantly associated with other histological parameters, including immunostaining for collagens I and III, the advanced glycation end product (AGE) N(ε)-(carboxymethyl)lysine (CML) and the receptor for AGEs (RAGE). When biomarkers were examined, cIB was weakly associated with log plasma levels of amino-terminal pro-B-type natriuretic peptide (r=0.34, p=0.03), creatinine (r=0.33, p=0.04) and glomerular filtration rate (r=-0.33, p=0.04), and was more strongly associated with log plasma levels of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) (r=0.44, p=0.01) and soluble RAGE (r=0.53, p=0.002).

Conclusions: Higher cIB was not a marker of increased myocardial fibrosis in patients with coronary artery disease, but was associated with higher plasma levels of sVEGFR-1 and soluble RAGE. The role of cIB as a non-invasive index of fibrosis in clinical studies of patients without extensive fibrosis is, therefore, questionable.

No MeSH data available.


Related in: MedlinePlus

Correlations of calibrated integrated backscatter (cIB) with log10 plasma soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) (A), and log10 plasma soluble receptor for advanced glycation end products (sRAGE) (B) in patients undergoing coronary artery bypass graft surgery, n=33. The correlations of cIB with log10 sVEGFR-1 and log10 sRAGE were also statistically significant using non-parametric Spearman correlations (r=0.41, p=0.02 for sVEGFR-1; r=0.40, p=0.02 for sRAGE).
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OPENHRT2015000278F2: Correlations of calibrated integrated backscatter (cIB) with log10 plasma soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) (A), and log10 plasma soluble receptor for advanced glycation end products (sRAGE) (B) in patients undergoing coronary artery bypass graft surgery, n=33. The correlations of cIB with log10 sVEGFR-1 and log10 sRAGE were also statistically significant using non-parametric Spearman correlations (r=0.41, p=0.02 for sVEGFR-1; r=0.40, p=0.02 for sRAGE).

Mentions: Of the plasma angiogenesis-related biomarkers evaluated (table 4), log soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and log soluble RAGE (sRAGE) were associated with increased cIB (figure 2), but not with capillary length density (data not shown).


Calibrated integrated backscatter and myocardial fibrosis in patients undergoing cardiac surgery.

Prior DL, Somaratne JB, Jenkins AJ, Yii M, Newcomb AE, Schalkwijk CG, Black MJ, Kelly DJ, Campbell DJ - Open Heart (2015)

Correlations of calibrated integrated backscatter (cIB) with log10 plasma soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) (A), and log10 plasma soluble receptor for advanced glycation end products (sRAGE) (B) in patients undergoing coronary artery bypass graft surgery, n=33. The correlations of cIB with log10 sVEGFR-1 and log10 sRAGE were also statistically significant using non-parametric Spearman correlations (r=0.41, p=0.02 for sVEGFR-1; r=0.40, p=0.02 for sRAGE).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555070&req=5

OPENHRT2015000278F2: Correlations of calibrated integrated backscatter (cIB) with log10 plasma soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) (A), and log10 plasma soluble receptor for advanced glycation end products (sRAGE) (B) in patients undergoing coronary artery bypass graft surgery, n=33. The correlations of cIB with log10 sVEGFR-1 and log10 sRAGE were also statistically significant using non-parametric Spearman correlations (r=0.41, p=0.02 for sVEGFR-1; r=0.40, p=0.02 for sRAGE).
Mentions: Of the plasma angiogenesis-related biomarkers evaluated (table 4), log soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and log soluble RAGE (sRAGE) were associated with increased cIB (figure 2), but not with capillary length density (data not shown).

Bottom Line: However, cIB was not significantly associated with other histological parameters, including immunostaining for collagens I and III, the advanced glycation end product (AGE) N(ε)-(carboxymethyl)lysine (CML) and the receptor for AGEs (RAGE).When biomarkers were examined, cIB was weakly associated with log plasma levels of amino-terminal pro-B-type natriuretic peptide (r=0.34, p=0.03), creatinine (r=0.33, p=0.04) and glomerular filtration rate (r=-0.33, p=0.04), and was more strongly associated with log plasma levels of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) (r=0.44, p=0.01) and soluble RAGE (r=0.53, p=0.002).Higher cIB was not a marker of increased myocardial fibrosis in patients with coronary artery disease, but was associated with higher plasma levels of sVEGFR-1 and soluble RAGE.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology , St. Vincent's Hospital Melbourne , Fitzroy , Australia ; Department of Medicine , University of Melbourne, St. Vincent's Hospital Melbourne , Fitzroy , Australia ; St. Vincent's Institute of Medical Research , Fitzroy , Australia.

ABSTRACT

Objective: The reported association between calibrated integrated backscatter (cIB) and myocardial fibrosis is based on study of patients with dilated or hypertrophic cardiomyopathy and extensive (mean 15-34%) fibrosis. Its association with lesser degrees of fibrosis is unknown. We examined the relationship between cIB and myocardial fibrosis in patients with coronary artery disease.

Methods: Myocardial histology was examined in left ventricular epicardial biopsies from 40 patients (29 men and 11 women) undergoing coronary artery bypass graft surgery, who had preoperative echocardiography with cIB measurement.

Results: Total fibrosis (picrosirius red staining) varied from 0.7% to 4%, and in contrast to previous reports, cIB showed weak inverse associations with total fibrosis (r=-0.32, p=0.047) and interstitial fibrosis (r=-0.34, p=0.03). However, cIB was not significantly associated with other histological parameters, including immunostaining for collagens I and III, the advanced glycation end product (AGE) N(ε)-(carboxymethyl)lysine (CML) and the receptor for AGEs (RAGE). When biomarkers were examined, cIB was weakly associated with log plasma levels of amino-terminal pro-B-type natriuretic peptide (r=0.34, p=0.03), creatinine (r=0.33, p=0.04) and glomerular filtration rate (r=-0.33, p=0.04), and was more strongly associated with log plasma levels of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) (r=0.44, p=0.01) and soluble RAGE (r=0.53, p=0.002).

Conclusions: Higher cIB was not a marker of increased myocardial fibrosis in patients with coronary artery disease, but was associated with higher plasma levels of sVEGFR-1 and soluble RAGE. The role of cIB as a non-invasive index of fibrosis in clinical studies of patients without extensive fibrosis is, therefore, questionable.

No MeSH data available.


Related in: MedlinePlus