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Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome.

Moti M, Amini L, Mirhoseini Ardakani SS, Kamalzadeh S, Masoomikarimi M, Jafarisani M - Iran J Reprod Med (2015)

Bottom Line: It is characterized by chronic anovulation, hyper androgenism and obesity.The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women.These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.

View Article: PubMed Central - PubMed

Affiliation: Department of Midwifery, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes.

Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran.

Materials and methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples.

Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women.

Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.

No MeSH data available.


Related in: MedlinePlus

The serum levels of advanced oxidation protein products (AOPPs) in women with polycystic ovary syndrome (PCOS) and control women. Data are shown as mean±SD
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Figure 1: The serum levels of advanced oxidation protein products (AOPPs) in women with polycystic ovary syndrome (PCOS) and control women. Data are shown as mean±SD

Mentions: The data showed that there were no significant differences in the fasting glucose, mean age, and BMI between the groups. The women with PCOS had significantly higher serum fasting insulin, CRP and LH levels, and higher LH/FSH ratio and HOMA-R than healthy women (for each parameter; p<0.047). However, TAOS was significantly lower in women with PCOS compared with healthy women (p=0.03). Plasma concentrations of AOPP were significantly higher in PCOS patients than in age- and BMI-matched control subjects (79.4±12.0 vs. 45.8±6.1; p=0.01) (Figure 1). Using the mean+2SD (56.2 pg/mL) for AOPP concentrations in the control group as a cut-off value, PCOS patients with AOPP concentrations >56.2 pg/mL were defined as the high-AOPP group (n=30) and those with values <56.2 pg/mL as the normal-AOPP group (n=30).


Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome.

Moti M, Amini L, Mirhoseini Ardakani SS, Kamalzadeh S, Masoomikarimi M, Jafarisani M - Iran J Reprod Med (2015)

The serum levels of advanced oxidation protein products (AOPPs) in women with polycystic ovary syndrome (PCOS) and control women. Data are shown as mean±SD
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555058&req=5

Figure 1: The serum levels of advanced oxidation protein products (AOPPs) in women with polycystic ovary syndrome (PCOS) and control women. Data are shown as mean±SD
Mentions: The data showed that there were no significant differences in the fasting glucose, mean age, and BMI between the groups. The women with PCOS had significantly higher serum fasting insulin, CRP and LH levels, and higher LH/FSH ratio and HOMA-R than healthy women (for each parameter; p<0.047). However, TAOS was significantly lower in women with PCOS compared with healthy women (p=0.03). Plasma concentrations of AOPP were significantly higher in PCOS patients than in age- and BMI-matched control subjects (79.4±12.0 vs. 45.8±6.1; p=0.01) (Figure 1). Using the mean+2SD (56.2 pg/mL) for AOPP concentrations in the control group as a cut-off value, PCOS patients with AOPP concentrations >56.2 pg/mL were defined as the high-AOPP group (n=30) and those with values <56.2 pg/mL as the normal-AOPP group (n=30).

Bottom Line: It is characterized by chronic anovulation, hyper androgenism and obesity.The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women.These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.

View Article: PubMed Central - PubMed

Affiliation: Department of Midwifery, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes.

Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran.

Materials and methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples.

Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women.

Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.

No MeSH data available.


Related in: MedlinePlus