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The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes.

Khooshideh M, Radi V, Hosseini R, Hosseini L - Iran J Reprod Med (2015)

Bottom Line: The sensitivity and specificity were respectively 81.3% and 100% for Fern test, 93% and 92.8% for Nitrazine test, 98.9% and 92.8% for PAMG-1 test.PAMG-1 test showed higher sensitivity (98.9% with p<0.001) and accuracy (98%) compared with conventional tests.Although PAMG-1showed a lower positive predictive value (PPV) compared to conventional tests such as Fern test (100%), it was shown to be more accurate.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: Premature rupture of membranes (PROM) is a common obstetric issue during pregnancy which might lead to serious fetal or maternal problems. Therefore, an appropriate diagnosis and management of PROM are of significant importance in patients.

Objective: The aim of this study was to determine the accuracy of placental alpha microglobuline-1 (PAMG-1) test in PROM diagnosis and compare this diagnostic method with other standard tests in diagnosis of PROM.

Materials and methods: In this prospective diagnostic accuracy study, patients with symptoms of membrane rupture in 16-39 weeks of gestation were involved. Three tests including Fern, Nitrazine and PAMG-1 were performed at the same time.

Results: PROM was confirmed in 86 patients out of 100. The sensitivity and specificity were respectively 81.3% and 100% for Fern test, 93% and 92.8% for Nitrazine test, 98.9% and 92.8% for PAMG-1 test. PAMG-1 test showed higher sensitivity (98.9% with p<0.001) and accuracy (98%) compared with conventional tests. Although PAMG-1showed a lower positive predictive value (PPV) compared to conventional tests such as Fern test (100%), it was shown to be more accurate.

Conclusion: The accuracy of PAMG-1 test was superior to both Fern and Nitrazine test in PROM diagnosis.

No MeSH data available.


Related in: MedlinePlus

Diagram of patients. Conventional tests (+): Fern test and/ or Nitrazin test are positive. Conventional tests (-): Fern Test and Nitrazin test are negative
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Figure 1: Diagram of patients. Conventional tests (+): Fern test and/ or Nitrazin test are positive. Conventional tests (-): Fern Test and Nitrazin test are negative

Mentions: The average age of 100 pregnant women at the 16th-39th weeks of gestation involved in the study was 26±5.5 years (17-40 years old) and average of gestational age was 34.2±6.2 weeks. 55% of pregnancies were term, 19% between 34-37 weeks and 26% less than 34 weeks. The results of tests have been shown in Figure 1. Initial observations and conventional tests confirmed PROM in 66 women and PAMG-1 test indicated PROM in 86 women. Finally 86% of involved mothers were diagnosed with PROM. Among 21 cases which were negative in at least one conventional test and positive in PAMG-1 test, 20 cases had PROM. Among these 20 cases, 14 cases had positive Nitrazine test and 5 cases had positive Ferning test.


The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes.

Khooshideh M, Radi V, Hosseini R, Hosseini L - Iran J Reprod Med (2015)

Diagram of patients. Conventional tests (+): Fern test and/ or Nitrazin test are positive. Conventional tests (-): Fern Test and Nitrazin test are negative
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555055&req=5

Figure 1: Diagram of patients. Conventional tests (+): Fern test and/ or Nitrazin test are positive. Conventional tests (-): Fern Test and Nitrazin test are negative
Mentions: The average age of 100 pregnant women at the 16th-39th weeks of gestation involved in the study was 26±5.5 years (17-40 years old) and average of gestational age was 34.2±6.2 weeks. 55% of pregnancies were term, 19% between 34-37 weeks and 26% less than 34 weeks. The results of tests have been shown in Figure 1. Initial observations and conventional tests confirmed PROM in 66 women and PAMG-1 test indicated PROM in 86 women. Finally 86% of involved mothers were diagnosed with PROM. Among 21 cases which were negative in at least one conventional test and positive in PAMG-1 test, 20 cases had PROM. Among these 20 cases, 14 cases had positive Nitrazine test and 5 cases had positive Ferning test.

Bottom Line: The sensitivity and specificity were respectively 81.3% and 100% for Fern test, 93% and 92.8% for Nitrazine test, 98.9% and 92.8% for PAMG-1 test.PAMG-1 test showed higher sensitivity (98.9% with p<0.001) and accuracy (98%) compared with conventional tests.Although PAMG-1showed a lower positive predictive value (PPV) compared to conventional tests such as Fern test (100%), it was shown to be more accurate.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: Premature rupture of membranes (PROM) is a common obstetric issue during pregnancy which might lead to serious fetal or maternal problems. Therefore, an appropriate diagnosis and management of PROM are of significant importance in patients.

Objective: The aim of this study was to determine the accuracy of placental alpha microglobuline-1 (PAMG-1) test in PROM diagnosis and compare this diagnostic method with other standard tests in diagnosis of PROM.

Materials and methods: In this prospective diagnostic accuracy study, patients with symptoms of membrane rupture in 16-39 weeks of gestation were involved. Three tests including Fern, Nitrazine and PAMG-1 were performed at the same time.

Results: PROM was confirmed in 86 patients out of 100. The sensitivity and specificity were respectively 81.3% and 100% for Fern test, 93% and 92.8% for Nitrazine test, 98.9% and 92.8% for PAMG-1 test. PAMG-1 test showed higher sensitivity (98.9% with p<0.001) and accuracy (98%) compared with conventional tests. Although PAMG-1showed a lower positive predictive value (PPV) compared to conventional tests such as Fern test (100%), it was shown to be more accurate.

Conclusion: The accuracy of PAMG-1 test was superior to both Fern and Nitrazine test in PROM diagnosis.

No MeSH data available.


Related in: MedlinePlus