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Association of cord blood levels of IL-17A, but not TGF-β with pre-term neonate.

Mobini M, Mirzaie S, Khorramdelazad H, Zainodini N, Sabzali Z, Ghyasi M, Mokhtari M, Bahramabadi R, Hakimi H, Ghorban K, Dadmanesh M, Ehsani V, Kazemi Arababadi M - Iran J Reprod Med (2015)

Bottom Line: It has been hypothesized that abnormal expression of the cytokines may be associated with unsuccessful pregnancy.Our results revealed that the serum levels of IL-17A were significantly decreased in pre-term neonates in comparison to full-term neonates.Based on these findings, it can be concluded that IL-17A may play crucial roles in induction of normal pregnancies and also probably participates in normal growth of fetus.

View Article: PubMed Central - PubMed

Affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

ABSTRACT

Background: It has been documented that cytokines play important roles in the induction of normal functions of the placenta. It has been hypothesized that abnormal expression of the cytokines may be associated with unsuccessful pregnancy.

Objective: The aim of this study was to compare the serum levels of interleukin-17A (IL-17A) and tumor growth factor (TGF-β) in pre-term, term neonates, and their corresponding mothers.

Materials and methods: This study was performed on 100 term and 60 pre-term neonates, and also on their corresponded mothers. Serum levels of IL-17A and TGF-β were examined by enzyme linked immunosorbent assay (ELISA).

Results: Our results revealed that the serum levels of IL-17A were significantly decreased in pre-term neonates in comparison to full-term neonates. However, the serum levels of IL-17A in the mothers either with pre-term or full-term neonates were not different. Also the serum levels of TGF-β were not changed in pre-term neonates and their mothers when compared with full-term neonates and their mothers, respectively.

Conclusion: Based on these findings, it can be concluded that IL-17A may play crucial roles in induction of normal pregnancies and also probably participates in normal growth of fetus.

No MeSH data available.


Related in: MedlinePlus

Serum levels of IL-17A and TGF-β in mothers of term and pre-term infants. The figure illustrates that serum levels of IL-17A (p=0.429) and TGF-β (p=0.413) were not significantly different in mothers of pre-term in comparison to term infants
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Figure 2: Serum levels of IL-17A and TGF-β in mothers of term and pre-term infants. The figure illustrates that serum levels of IL-17A (p=0.429) and TGF-β (p=0.413) were not significantly different in mothers of pre-term in comparison to term infants

Mentions: The results also showed that the serum levels of TGF-β in term, and pre-term newborns and their corresponding; mothers were 70.22±10.99, 48.09±4.44, 58.34±9.09 and 48.00±8.54 pg/ml, respectively. Statistical analysis revealed that contrary to their mother (p=0.41), the differences between neonates (p=0.04) were significant (Figure 2). Our results also showed that inter- and intra-assays were CV <14% and CV <0.03%, respectively.


Association of cord blood levels of IL-17A, but not TGF-β with pre-term neonate.

Mobini M, Mirzaie S, Khorramdelazad H, Zainodini N, Sabzali Z, Ghyasi M, Mokhtari M, Bahramabadi R, Hakimi H, Ghorban K, Dadmanesh M, Ehsani V, Kazemi Arababadi M - Iran J Reprod Med (2015)

Serum levels of IL-17A and TGF-β in mothers of term and pre-term infants. The figure illustrates that serum levels of IL-17A (p=0.429) and TGF-β (p=0.413) were not significantly different in mothers of pre-term in comparison to term infants
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555053&req=5

Figure 2: Serum levels of IL-17A and TGF-β in mothers of term and pre-term infants. The figure illustrates that serum levels of IL-17A (p=0.429) and TGF-β (p=0.413) were not significantly different in mothers of pre-term in comparison to term infants
Mentions: The results also showed that the serum levels of TGF-β in term, and pre-term newborns and their corresponding; mothers were 70.22±10.99, 48.09±4.44, 58.34±9.09 and 48.00±8.54 pg/ml, respectively. Statistical analysis revealed that contrary to their mother (p=0.41), the differences between neonates (p=0.04) were significant (Figure 2). Our results also showed that inter- and intra-assays were CV <14% and CV <0.03%, respectively.

Bottom Line: It has been hypothesized that abnormal expression of the cytokines may be associated with unsuccessful pregnancy.Our results revealed that the serum levels of IL-17A were significantly decreased in pre-term neonates in comparison to full-term neonates.Based on these findings, it can be concluded that IL-17A may play crucial roles in induction of normal pregnancies and also probably participates in normal growth of fetus.

View Article: PubMed Central - PubMed

Affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

ABSTRACT

Background: It has been documented that cytokines play important roles in the induction of normal functions of the placenta. It has been hypothesized that abnormal expression of the cytokines may be associated with unsuccessful pregnancy.

Objective: The aim of this study was to compare the serum levels of interleukin-17A (IL-17A) and tumor growth factor (TGF-β) in pre-term, term neonates, and their corresponding mothers.

Materials and methods: This study was performed on 100 term and 60 pre-term neonates, and also on their corresponded mothers. Serum levels of IL-17A and TGF-β were examined by enzyme linked immunosorbent assay (ELISA).

Results: Our results revealed that the serum levels of IL-17A were significantly decreased in pre-term neonates in comparison to full-term neonates. However, the serum levels of IL-17A in the mothers either with pre-term or full-term neonates were not different. Also the serum levels of TGF-β were not changed in pre-term neonates and their mothers when compared with full-term neonates and their mothers, respectively.

Conclusion: Based on these findings, it can be concluded that IL-17A may play crucial roles in induction of normal pregnancies and also probably participates in normal growth of fetus.

No MeSH data available.


Related in: MedlinePlus