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Adenomyosis and its impact on women fertility.

Garavaglia E, Audrey S, Annalisa I, Stefano F, Iacopo T, Laura C, Massimo C - Iran J Reprod Med (2015)

Bottom Line: In the last ten years, different pathogenetic hypotheses have been proposed to explain the initiation and development of the disease.A PubMed search was undertaken for English language literature using the MeSH terms 'adenomyosis', 'infertility', 'treatment', and 'pathogenesis'.The understanding of these mechanisms helps to clarify the potential usefulness of current therapies.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, IRCCS San Raffaele, Via Olgettina 60, Milan, Italy.

ABSTRACT
Adenomyosis is a widespread disease affecting the reproductive period of women's life. In the last ten years, different pathogenetic hypotheses have been proposed to explain the initiation and development of the disease. This article aims to present and discuss the most important pathophysiologic mechanisms underlying adenomyosis development in order to clarify the relationship between adenomyosis and infertility. A PubMed search was undertaken for English language literature using the MeSH terms 'adenomyosis', 'infertility', 'treatment', and 'pathogenesis'. Although the exact etiology of adenomyosis is unknown, many theories have been proposed. We analysed the most important pathogenic theories expressed and evaluated the potential consequences on women fertility. A better comprehension of the adenomyosis pathogenesis has allowed realizing that adenomyosis may affect young women and may have a great impact on their fertility through different mechanisms. The understanding of these mechanisms helps to clarify the potential usefulness of current therapies.

No MeSH data available.


Related in: MedlinePlus

TIAR system: The mechanism of tissue traumatization and healing is associated with a specific physiological process that involves the local production of Interleukin-1-(IL-1). IL-1-induced activation of the cyclooxygenase-2 enzyme (COX-2) results in the production of prostaglandin E2 (PGE2), which in turn activates STAR (steroidogenic acute regulatory protein) and the P450 aromatase. Thus, testosterone can be formed and aromatized into E2 that exerts its proliferative and healing effects via the ER2. Hyperperistalsis would constitute a mechanical trauma resulting in an increased desquamation of fragments of basal endometrium and, in combination with an increased retrograde uterine transport capacity, in enhanced transtubal dissemination of these fragments. Hyperperistalsis and increased intrauterine pressure would with time, result in myometrial dehiscences that are infiltrated by basal endometrium with the secondary development of peristromal muscular tissue
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Figure 2: TIAR system: The mechanism of tissue traumatization and healing is associated with a specific physiological process that involves the local production of Interleukin-1-(IL-1). IL-1-induced activation of the cyclooxygenase-2 enzyme (COX-2) results in the production of prostaglandin E2 (PGE2), which in turn activates STAR (steroidogenic acute regulatory protein) and the P450 aromatase. Thus, testosterone can be formed and aromatized into E2 that exerts its proliferative and healing effects via the ER2. Hyperperistalsis would constitute a mechanical trauma resulting in an increased desquamation of fragments of basal endometrium and, in combination with an increased retrograde uterine transport capacity, in enhanced transtubal dissemination of these fragments. Hyperperistalsis and increased intrauterine pressure would with time, result in myometrial dehiscences that are infiltrated by basal endometrium with the secondary development of peristromal muscular tissue

Mentions: Hyperperistalsis induced by the local production of estrogen would constitute a mechanical trauma resulting in an increased desquamation of fragments of basal endometrium and in combination with an increased retrograde uterine transport capacity in an enhanced transtubal dissemination of these fragments. Hyperperistalsis and increased intrauterine pressure would with time, result in myometrial dehiscences that are infiltrated by basal endometrium with the secondary development of peristromal muscular tissue. Diffuse or focal adenomyosis of various extents might ensue (11, 13, 15, 18-22) (Figure 1, 2).


Adenomyosis and its impact on women fertility.

Garavaglia E, Audrey S, Annalisa I, Stefano F, Iacopo T, Laura C, Massimo C - Iran J Reprod Med (2015)

TIAR system: The mechanism of tissue traumatization and healing is associated with a specific physiological process that involves the local production of Interleukin-1-(IL-1). IL-1-induced activation of the cyclooxygenase-2 enzyme (COX-2) results in the production of prostaglandin E2 (PGE2), which in turn activates STAR (steroidogenic acute regulatory protein) and the P450 aromatase. Thus, testosterone can be formed and aromatized into E2 that exerts its proliferative and healing effects via the ER2. Hyperperistalsis would constitute a mechanical trauma resulting in an increased desquamation of fragments of basal endometrium and, in combination with an increased retrograde uterine transport capacity, in enhanced transtubal dissemination of these fragments. Hyperperistalsis and increased intrauterine pressure would with time, result in myometrial dehiscences that are infiltrated by basal endometrium with the secondary development of peristromal muscular tissue
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4555051&req=5

Figure 2: TIAR system: The mechanism of tissue traumatization and healing is associated with a specific physiological process that involves the local production of Interleukin-1-(IL-1). IL-1-induced activation of the cyclooxygenase-2 enzyme (COX-2) results in the production of prostaglandin E2 (PGE2), which in turn activates STAR (steroidogenic acute regulatory protein) and the P450 aromatase. Thus, testosterone can be formed and aromatized into E2 that exerts its proliferative and healing effects via the ER2. Hyperperistalsis would constitute a mechanical trauma resulting in an increased desquamation of fragments of basal endometrium and, in combination with an increased retrograde uterine transport capacity, in enhanced transtubal dissemination of these fragments. Hyperperistalsis and increased intrauterine pressure would with time, result in myometrial dehiscences that are infiltrated by basal endometrium with the secondary development of peristromal muscular tissue
Mentions: Hyperperistalsis induced by the local production of estrogen would constitute a mechanical trauma resulting in an increased desquamation of fragments of basal endometrium and in combination with an increased retrograde uterine transport capacity in an enhanced transtubal dissemination of these fragments. Hyperperistalsis and increased intrauterine pressure would with time, result in myometrial dehiscences that are infiltrated by basal endometrium with the secondary development of peristromal muscular tissue. Diffuse or focal adenomyosis of various extents might ensue (11, 13, 15, 18-22) (Figure 1, 2).

Bottom Line: In the last ten years, different pathogenetic hypotheses have been proposed to explain the initiation and development of the disease.A PubMed search was undertaken for English language literature using the MeSH terms 'adenomyosis', 'infertility', 'treatment', and 'pathogenesis'.The understanding of these mechanisms helps to clarify the potential usefulness of current therapies.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, IRCCS San Raffaele, Via Olgettina 60, Milan, Italy.

ABSTRACT
Adenomyosis is a widespread disease affecting the reproductive period of women's life. In the last ten years, different pathogenetic hypotheses have been proposed to explain the initiation and development of the disease. This article aims to present and discuss the most important pathophysiologic mechanisms underlying adenomyosis development in order to clarify the relationship between adenomyosis and infertility. A PubMed search was undertaken for English language literature using the MeSH terms 'adenomyosis', 'infertility', 'treatment', and 'pathogenesis'. Although the exact etiology of adenomyosis is unknown, many theories have been proposed. We analysed the most important pathogenic theories expressed and evaluated the potential consequences on women fertility. A better comprehension of the adenomyosis pathogenesis has allowed realizing that adenomyosis may affect young women and may have a great impact on their fertility through different mechanisms. The understanding of these mechanisms helps to clarify the potential usefulness of current therapies.

No MeSH data available.


Related in: MedlinePlus