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The short-term and long-term outcomes of the endoscopic resection for the superficial pharyngeal squamous cell carcinoma.

Kinjo Y, Nonaka S, Oda I, Abe S, Suzuki H, Yoshinaga S, Maki D, Yoshimoto S, Taniguchi H, Saito Y - Endosc Int Open (2015)

Bottom Line: There were no significant complications in both groups.ER for SPSCC is a feasible treatment with promising results.Tumor thickness over 1000 μm is a significant risk factor for LNM and positive or inconclusive horizontal margin is a risk factor for local recurrence.

View Article: PubMed Central - PubMed

Affiliation: Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

ABSTRACT

Background and study aims: Early detection of superficial pharyngeal squamous cell carcinoma (SPSCC) using narrow-band imaging as well as the increasing use of ER for gastrointestinal cancers may increase the number of ER for SPSCC. The aims of this study were to clarify the feasibility of ER for SPSCC and its long-term outcomes.

Patients and methods: In total, 84 patients with 115 lesions were treated by endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) between March 2004 and August 2012. We retrospectively assessed the en bloc and R0 resection rates, complications, lymph node metastasis (LNM), local recurrence, metachronous pharyngeal and esophageal SCC, 5-year overall and cause-specific survival rates.

Results: Higher proportions of en bloc and R0 resection were achieved with ESD compared to EMR (en bloc 100 % vs. 60 %, P < 0.001; R0 59 % vs. 26 %, P < 0.005). There were no significant complications in both groups. None of the patients died from primary SPSCC during the median follow-up of 34 months (range, 3 - 115). LNM occurred in three patients and local recurrence was detected in seven patients (8.3 %) with eight lesions. Tumor thickness over 1000 μm (P < 0.005) and positive or inconclusive horizontal margins (P < 0.05) were significant risk factors for LNM and local recurrence, respectively. Twelve patients died because of co-existing clinical conditions. The 5-year overall and cause-specific survival rates were 80.7 % and 100 %, respectively.

Conclusions: ER for SPSCC is a feasible treatment with promising results. Tumor thickness over 1000 μm is a significant risk factor for LNM and positive or inconclusive horizontal margin is a risk factor for local recurrence.

No MeSH data available.


Related in: MedlinePlus

 Overall survival after ER.
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FI201-7:  Overall survival after ER.

Mentions: Metachronous pharyngeal SCC occurred in 18 patients (21 %) with 26 lesions a median period of 17 months (6 – 50) after initial ER. In total, 22 lesions were located in the hypopharynx and four lesions were located in the oropharynx. The median tumor size was 13 mm (5 – 50). The cumulative incidence rates at 3 and 5 years were 17.8 % and 25.3 %, respectively (Fig. 6). Regarding the treatment of these metachronous tumors, ER was performed in 17 lesions, RT in three lesions and the remaining six lesions underwent extensive surgical resection. Neither tumor-related death nor distant metastasis occurred among these patients. Metachronous esophageal SCC was also detected in 19 patients (23 %) with 29 lesions a median period of 34 months (3 – 115) after initial ER. Although 26 metachronous lesions were treated by ER and two lesions by APC is enough because of prior correction. In one case treatment has been postponed because of co-existing disease. No patient died from primary SPSCC, metachronous pharyngeal or esophageal SCC during the follow-up period. In total, 12 patients died from co-existing diseases including nine cancers (five esophageal SCCs, two lung cancers, one tongue cancer, and one cholangiocarcinoma) a median period of 31 months (8 – 85) after initial ER. The overall survival rates at 3 and 5 years were 91.1 % and 80.7 %, respectively (Fig. 7).


The short-term and long-term outcomes of the endoscopic resection for the superficial pharyngeal squamous cell carcinoma.

Kinjo Y, Nonaka S, Oda I, Abe S, Suzuki H, Yoshinaga S, Maki D, Yoshimoto S, Taniguchi H, Saito Y - Endosc Int Open (2015)

 Overall survival after ER.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4554513&req=5

FI201-7:  Overall survival after ER.
Mentions: Metachronous pharyngeal SCC occurred in 18 patients (21 %) with 26 lesions a median period of 17 months (6 – 50) after initial ER. In total, 22 lesions were located in the hypopharynx and four lesions were located in the oropharynx. The median tumor size was 13 mm (5 – 50). The cumulative incidence rates at 3 and 5 years were 17.8 % and 25.3 %, respectively (Fig. 6). Regarding the treatment of these metachronous tumors, ER was performed in 17 lesions, RT in three lesions and the remaining six lesions underwent extensive surgical resection. Neither tumor-related death nor distant metastasis occurred among these patients. Metachronous esophageal SCC was also detected in 19 patients (23 %) with 29 lesions a median period of 34 months (3 – 115) after initial ER. Although 26 metachronous lesions were treated by ER and two lesions by APC is enough because of prior correction. In one case treatment has been postponed because of co-existing disease. No patient died from primary SPSCC, metachronous pharyngeal or esophageal SCC during the follow-up period. In total, 12 patients died from co-existing diseases including nine cancers (five esophageal SCCs, two lung cancers, one tongue cancer, and one cholangiocarcinoma) a median period of 31 months (8 – 85) after initial ER. The overall survival rates at 3 and 5 years were 91.1 % and 80.7 %, respectively (Fig. 7).

Bottom Line: There were no significant complications in both groups.ER for SPSCC is a feasible treatment with promising results.Tumor thickness over 1000 μm is a significant risk factor for LNM and positive or inconclusive horizontal margin is a risk factor for local recurrence.

View Article: PubMed Central - PubMed

Affiliation: Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

ABSTRACT

Background and study aims: Early detection of superficial pharyngeal squamous cell carcinoma (SPSCC) using narrow-band imaging as well as the increasing use of ER for gastrointestinal cancers may increase the number of ER for SPSCC. The aims of this study were to clarify the feasibility of ER for SPSCC and its long-term outcomes.

Patients and methods: In total, 84 patients with 115 lesions were treated by endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) between March 2004 and August 2012. We retrospectively assessed the en bloc and R0 resection rates, complications, lymph node metastasis (LNM), local recurrence, metachronous pharyngeal and esophageal SCC, 5-year overall and cause-specific survival rates.

Results: Higher proportions of en bloc and R0 resection were achieved with ESD compared to EMR (en bloc 100 % vs. 60 %, P < 0.001; R0 59 % vs. 26 %, P < 0.005). There were no significant complications in both groups. None of the patients died from primary SPSCC during the median follow-up of 34 months (range, 3 - 115). LNM occurred in three patients and local recurrence was detected in seven patients (8.3 %) with eight lesions. Tumor thickness over 1000 μm (P < 0.005) and positive or inconclusive horizontal margins (P < 0.05) were significant risk factors for LNM and local recurrence, respectively. Twelve patients died because of co-existing clinical conditions. The 5-year overall and cause-specific survival rates were 80.7 % and 100 %, respectively.

Conclusions: ER for SPSCC is a feasible treatment with promising results. Tumor thickness over 1000 μm is a significant risk factor for LNM and positive or inconclusive horizontal margin is a risk factor for local recurrence.

No MeSH data available.


Related in: MedlinePlus