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A prospective randomized study of the difference in diagnostic yield between endoscopic ultrasound-guided fine-needle aspiration (EUSFNA) needles with and without a side port in pancreatic masses.

Ang TL, Kwek AB, Seo DW, Paik WH, Cheng TY, Wang HP, Lau J - Endosc Int Open (2015)

Bottom Line: B: 25/30 vs. 26/30 (P = 0.718).B: 26/30 vs. 26/30 (P = 1.0).NCT02092519.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

ABSTRACT

Background and study aims: Two 22G needles with similar designs, apart from the absence (A) or presence of a side port (B), are available for endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA). The side port was designed to increase diagnostic yield but this advantage was unproven. This study evaluated the difference in diagnostic yield between both needles in pancreatic masses.

Patients and methods: This was a prospective multicenter randomized cross-over study. Patients with pancreatic masses were randomized to one needle for the first two passes, followed by the other for the next two passes. A pathologist blinded to the needle assessed each puncture for cellularity and morphology. The diagnostic yield between both needles was compared.

Results: In total, 30 patients were recruited (mean lesion size: 3.5 cm, range: 1.2 - 6.3). Comparison of cellularity adequacy: first pass: A vs. B: 26/30 vs. 24/30 (P = 0.488): 2nd pass: A vs. B: 25/30 vs. 26/30 (P = 0.718). Comparison of diagnostic accuracy: first pass: A vs. B: 22/30 vs. 23/30 (P = 0.766); after two passes: A vs. B: 26/30 vs. 26/30 (P = 1.0). When all four passes were assessed, adequate cellularity was obtained in 29/30 and the correct diagnosis was obtained in 28/30 patients. There were no procedural complications.

Conclusions: There was no significant difference in diagnostic yield between EUSFNA needles with or without a side port for pancreatic masses.

Study registration: NCT02092519.

No MeSH data available.


Related in: MedlinePlus

 Tip of needle showing the side port.
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FI192-1:  Tip of needle showing the side port.

Mentions: The two 22G needles being compared were both manufactured by Olympus (Tokyo, Japan) and were similar in design apart from the absence or presence of a side port, i. e. EZ-Shot 2 (model: NA-220H-8022) and EZ-Shot 2 with side port (NA-230H-8022) (Fig. 1). The needles were packaged with a 20 mL syringe for application of suction. Full suction was used during EUSFNA. Randomization of the needle used for initial puncture was carried in blocks of five with equal assignment. Once the first two punctures had been performed, the alternative needle was used for the subsequent two needle passes.


A prospective randomized study of the difference in diagnostic yield between endoscopic ultrasound-guided fine-needle aspiration (EUSFNA) needles with and without a side port in pancreatic masses.

Ang TL, Kwek AB, Seo DW, Paik WH, Cheng TY, Wang HP, Lau J - Endosc Int Open (2015)

 Tip of needle showing the side port.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4554507&req=5

FI192-1:  Tip of needle showing the side port.
Mentions: The two 22G needles being compared were both manufactured by Olympus (Tokyo, Japan) and were similar in design apart from the absence or presence of a side port, i. e. EZ-Shot 2 (model: NA-220H-8022) and EZ-Shot 2 with side port (NA-230H-8022) (Fig. 1). The needles were packaged with a 20 mL syringe for application of suction. Full suction was used during EUSFNA. Randomization of the needle used for initial puncture was carried in blocks of five with equal assignment. Once the first two punctures had been performed, the alternative needle was used for the subsequent two needle passes.

Bottom Line: B: 25/30 vs. 26/30 (P = 0.718).B: 26/30 vs. 26/30 (P = 1.0).NCT02092519.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

ABSTRACT

Background and study aims: Two 22G needles with similar designs, apart from the absence (A) or presence of a side port (B), are available for endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA). The side port was designed to increase diagnostic yield but this advantage was unproven. This study evaluated the difference in diagnostic yield between both needles in pancreatic masses.

Patients and methods: This was a prospective multicenter randomized cross-over study. Patients with pancreatic masses were randomized to one needle for the first two passes, followed by the other for the next two passes. A pathologist blinded to the needle assessed each puncture for cellularity and morphology. The diagnostic yield between both needles was compared.

Results: In total, 30 patients were recruited (mean lesion size: 3.5 cm, range: 1.2 - 6.3). Comparison of cellularity adequacy: first pass: A vs. B: 26/30 vs. 24/30 (P = 0.488): 2nd pass: A vs. B: 25/30 vs. 26/30 (P = 0.718). Comparison of diagnostic accuracy: first pass: A vs. B: 22/30 vs. 23/30 (P = 0.766); after two passes: A vs. B: 26/30 vs. 26/30 (P = 1.0). When all four passes were assessed, adequate cellularity was obtained in 29/30 and the correct diagnosis was obtained in 28/30 patients. There were no procedural complications.

Conclusions: There was no significant difference in diagnostic yield between EUSFNA needles with or without a side port for pancreatic masses.

Study registration: NCT02092519.

No MeSH data available.


Related in: MedlinePlus