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Spotlight on nano-theranostics in South Korea: applications in diagnostics and treatment of diseases.

Lee S, Kim J, Bark CW, Lee B, Ju H, Kang SC, Kim T, Kim MI, Ko YT, Nam JS, Yoon HH, Yun KS, Yoon YS, An SS, Hulme J - Int J Nanomedicine (2015)

Bottom Line: From the synergistic integration and the multidisciplinary strengths of the BioNano Sensor Research Center, Gachon Bionano Research Institute, and Lee Gil Ya Cancer and Diabetes Institute, researchers, students, and faculties at Gachon University in collaboration with other institutions in Korea, Australia, France, America, and Japan have come together to produce a special issue on the diverse applications of nano-theranostics in nanomedicine.This special issue will showcase new research conducted by various scientific groups in Gyonggi-do and Songdo/Incheon, South Korea.The objectives of this special issue are as follows: 1) to bring together and demonstrate some of the latest research results in the field, 2) to introduce new multifunctional nanomaterials and their applications in imaging and detection methods, and 3) to stimulate collaborative interdisciplinary research at both national and international levels in nanomedicine.

View Article: PubMed Central - PubMed

Affiliation: BioNano Sensor Research Center, Gachon University, Seongnam-si, South Korea.

ABSTRACT
From the synergistic integration and the multidisciplinary strengths of the BioNano Sensor Research Center, Gachon Bionano Research Institute, and Lee Gil Ya Cancer and Diabetes Institute, researchers, students, and faculties at Gachon University in collaboration with other institutions in Korea, Australia, France, America, and Japan have come together to produce a special issue on the diverse applications of nano-theranostics in nanomedicine. This special issue will showcase new research conducted by various scientific groups in Gyonggi-do and Songdo/Incheon, South Korea. The objectives of this special issue are as follows: 1) to bring together and demonstrate some of the latest research results in the field, 2) to introduce new multifunctional nanomaterials and their applications in imaging and detection methods, and 3) to stimulate collaborative interdisciplinary research at both national and international levels in nanomedicine.

No MeSH data available.


Related in: MedlinePlus

The aggregation behavior of AgcoreAushell NPs with and without DA molecules at various pH ranges.Abbreviations: NPs, nanoparticles; DA, dopamine.
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f2-ijn-10-003: The aggregation behavior of AgcoreAushell NPs with and without DA molecules at various pH ranges.Abbreviations: NPs, nanoparticles; DA, dopamine.

Mentions: The paper by Zhong et al investigates the antibacterial properties of GO modified ZnO nanoparticles were investigated. The researchers present a novel antibacterial mechanism for the formation of reactive oxygen species using the substrate. Govindaraju et al provided a detailed investigation regarding the antibacterial properties of broadband UV and laser irradiated functionalized gold nanoparticles on Escherichia coli. Ramasamy et al examined the effects of modifying the surface of gold nanorods with silica on the growth and viability of pathogenic E. coli O157:H7. Bu et al presented a paper in which the characteristics of AgcoreAushell nanoparticles as SERS substrates for the sensitive detection of dopamine were investigated. The authors propose that dopamine can act as a molecular bridge between nanoparticles, which can induce a profound influence on the SERS activity of colloidal systems. Figure 2 illustrates the pH-dependent interaction of the AgcoreAushell NPs with DA molecules at various pH ranges. Kim et al utilized dopamine-functionalized InP/ZnS quantum dots (QDs) as fluorescence probes for the detection of adenosine in microfluidic chips. Adenosine is an inhibitory neurotransmitter and a signaling molecule that is involved in energy production in the form of ATP at the molecular level. In this investigation, researchers use adenosine to competitively inhibit the binding of zinc ions to different types of dopamine conjugated QDs. It was found that the proposed fluorescence bio-probe has potential application in biological systems for the detection of adenosine in solution and serum at low concentration levels. In another paper by Kim et al the fluorescence quenching of cysteine-capped InP/ZnS QDs by dopamine and ascorbic acid was investigated. The quenching of the QDs was significantly higher for dopamine than ascorbic acid. The analytical performance of this assay for DA was assessed, and it was found that the limit of detection was 875 pM. The following paper by Subbiah et al examined the effects of different concentrations of silver nanoparticles on the physicomechanical responses of human alveolar epithelial cells (A549), mouse fibroblasts (NIH3T3), and human bone marrow stromal cells (hBMSC; HS-5). The authors reported that alterations in cellular morphology were directly proportional to the level of AgNP-induced cytotoxicity. AgNPs, treatment increased the surface roughness (P<0.001) but more importantly the stiffness (P<0.001) of all the cell lines investigated.


Spotlight on nano-theranostics in South Korea: applications in diagnostics and treatment of diseases.

Lee S, Kim J, Bark CW, Lee B, Ju H, Kang SC, Kim T, Kim MI, Ko YT, Nam JS, Yoon HH, Yun KS, Yoon YS, An SS, Hulme J - Int J Nanomedicine (2015)

The aggregation behavior of AgcoreAushell NPs with and without DA molecules at various pH ranges.Abbreviations: NPs, nanoparticles; DA, dopamine.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554482&req=5

f2-ijn-10-003: The aggregation behavior of AgcoreAushell NPs with and without DA molecules at various pH ranges.Abbreviations: NPs, nanoparticles; DA, dopamine.
Mentions: The paper by Zhong et al investigates the antibacterial properties of GO modified ZnO nanoparticles were investigated. The researchers present a novel antibacterial mechanism for the formation of reactive oxygen species using the substrate. Govindaraju et al provided a detailed investigation regarding the antibacterial properties of broadband UV and laser irradiated functionalized gold nanoparticles on Escherichia coli. Ramasamy et al examined the effects of modifying the surface of gold nanorods with silica on the growth and viability of pathogenic E. coli O157:H7. Bu et al presented a paper in which the characteristics of AgcoreAushell nanoparticles as SERS substrates for the sensitive detection of dopamine were investigated. The authors propose that dopamine can act as a molecular bridge between nanoparticles, which can induce a profound influence on the SERS activity of colloidal systems. Figure 2 illustrates the pH-dependent interaction of the AgcoreAushell NPs with DA molecules at various pH ranges. Kim et al utilized dopamine-functionalized InP/ZnS quantum dots (QDs) as fluorescence probes for the detection of adenosine in microfluidic chips. Adenosine is an inhibitory neurotransmitter and a signaling molecule that is involved in energy production in the form of ATP at the molecular level. In this investigation, researchers use adenosine to competitively inhibit the binding of zinc ions to different types of dopamine conjugated QDs. It was found that the proposed fluorescence bio-probe has potential application in biological systems for the detection of adenosine in solution and serum at low concentration levels. In another paper by Kim et al the fluorescence quenching of cysteine-capped InP/ZnS QDs by dopamine and ascorbic acid was investigated. The quenching of the QDs was significantly higher for dopamine than ascorbic acid. The analytical performance of this assay for DA was assessed, and it was found that the limit of detection was 875 pM. The following paper by Subbiah et al examined the effects of different concentrations of silver nanoparticles on the physicomechanical responses of human alveolar epithelial cells (A549), mouse fibroblasts (NIH3T3), and human bone marrow stromal cells (hBMSC; HS-5). The authors reported that alterations in cellular morphology were directly proportional to the level of AgNP-induced cytotoxicity. AgNPs, treatment increased the surface roughness (P<0.001) but more importantly the stiffness (P<0.001) of all the cell lines investigated.

Bottom Line: From the synergistic integration and the multidisciplinary strengths of the BioNano Sensor Research Center, Gachon Bionano Research Institute, and Lee Gil Ya Cancer and Diabetes Institute, researchers, students, and faculties at Gachon University in collaboration with other institutions in Korea, Australia, France, America, and Japan have come together to produce a special issue on the diverse applications of nano-theranostics in nanomedicine.This special issue will showcase new research conducted by various scientific groups in Gyonggi-do and Songdo/Incheon, South Korea.The objectives of this special issue are as follows: 1) to bring together and demonstrate some of the latest research results in the field, 2) to introduce new multifunctional nanomaterials and their applications in imaging and detection methods, and 3) to stimulate collaborative interdisciplinary research at both national and international levels in nanomedicine.

View Article: PubMed Central - PubMed

Affiliation: BioNano Sensor Research Center, Gachon University, Seongnam-si, South Korea.

ABSTRACT
From the synergistic integration and the multidisciplinary strengths of the BioNano Sensor Research Center, Gachon Bionano Research Institute, and Lee Gil Ya Cancer and Diabetes Institute, researchers, students, and faculties at Gachon University in collaboration with other institutions in Korea, Australia, France, America, and Japan have come together to produce a special issue on the diverse applications of nano-theranostics in nanomedicine. This special issue will showcase new research conducted by various scientific groups in Gyonggi-do and Songdo/Incheon, South Korea. The objectives of this special issue are as follows: 1) to bring together and demonstrate some of the latest research results in the field, 2) to introduce new multifunctional nanomaterials and their applications in imaging and detection methods, and 3) to stimulate collaborative interdisciplinary research at both national and international levels in nanomedicine.

No MeSH data available.


Related in: MedlinePlus