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Paracoccus denitrificans possesses two BioR homologs having a role in regulation of biotin metabolism.

Feng Y, Kumar R, Ravcheev DA, Zhang H - Microbiologyopen (2015)

Bottom Line: The identity of the purified BioR proteins (BioR1 and BioR2) was confirmed with LC-QToF-MS.EMSA-based screening failed to demonstrate that the biotin-related metabolite is involved in BioR-DNA interplay, which is consistent with our former observation with Brucella BioR.Our finding defined a complex regulatory network for biotin metabolism in P. denitrificans by two BioR proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology & Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.

No MeSH data available.


Related in: MedlinePlus

Phylogenetic trees for the biotin synthesis proteins duplicated in Paracoccus denitrificans and their orthologs in Rhodobacterales and Rhizobiales genomes. (A) Phylogenetic tree of the BioR homologs. (B) Phylogenetic tree of the BioB proteins. (C) Phylogenetic tree of the BioY transporters.
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fig03: Phylogenetic trees for the biotin synthesis proteins duplicated in Paracoccus denitrificans and their orthologs in Rhodobacterales and Rhizobiales genomes. (A) Phylogenetic tree of the BioR homologs. (B) Phylogenetic tree of the BioB proteins. (C) Phylogenetic tree of the BioY transporters.

Mentions: For better understanding of origin of the duplicated genes, bioR (Fig.3A), bioB (Fig.3B), and bioY (Fig.3C), we analyzed their orthologs in genomes of Rhizobiales and Rhodobacterales. These phylogenetic analyses revealed that at least bioR1 gene (pden_1431) and bioYB2 operon (pden_1432-33) might be products of the horizontal transfer from Azorhizobium caulinodans or the related species (Fig.3).


Paracoccus denitrificans possesses two BioR homologs having a role in regulation of biotin metabolism.

Feng Y, Kumar R, Ravcheev DA, Zhang H - Microbiologyopen (2015)

Phylogenetic trees for the biotin synthesis proteins duplicated in Paracoccus denitrificans and their orthologs in Rhodobacterales and Rhizobiales genomes. (A) Phylogenetic tree of the BioR homologs. (B) Phylogenetic tree of the BioB proteins. (C) Phylogenetic tree of the BioY transporters.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554459&req=5

fig03: Phylogenetic trees for the biotin synthesis proteins duplicated in Paracoccus denitrificans and their orthologs in Rhodobacterales and Rhizobiales genomes. (A) Phylogenetic tree of the BioR homologs. (B) Phylogenetic tree of the BioB proteins. (C) Phylogenetic tree of the BioY transporters.
Mentions: For better understanding of origin of the duplicated genes, bioR (Fig.3A), bioB (Fig.3B), and bioY (Fig.3C), we analyzed their orthologs in genomes of Rhizobiales and Rhodobacterales. These phylogenetic analyses revealed that at least bioR1 gene (pden_1431) and bioYB2 operon (pden_1432-33) might be products of the horizontal transfer from Azorhizobium caulinodans or the related species (Fig.3).

Bottom Line: The identity of the purified BioR proteins (BioR1 and BioR2) was confirmed with LC-QToF-MS.EMSA-based screening failed to demonstrate that the biotin-related metabolite is involved in BioR-DNA interplay, which is consistent with our former observation with Brucella BioR.Our finding defined a complex regulatory network for biotin metabolism in P. denitrificans by two BioR proteins.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology & Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.

No MeSH data available.


Related in: MedlinePlus