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Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties.

Zhong L, Yun K - Int J Nanomedicine (2015)

Bottom Line: The morphology of the graphene oxide sheets and ZnO particles was confirmed with field emission scanning electron microscopy and biological atomic force microscopy.Enhanced electrochemical properties were detected with cyclic voltammetry, with a redox peak of the composites at 0.025 mV.After further study of the antibacterial mechanism, we concluded that a vast number of reactive oxygen species formed on the surface of composites, improving antibacterial properties.

View Article: PubMed Central - PubMed

Affiliation: Department of Bionanotechnology, Gachon University, Gyeonggi-do, Republic of Korea.

ABSTRACT
Nanosized ZnO particles with diameters of 15 nm were prepared with a solution precipitation method at low cost and high yield. The synthesis of the particles was functionalized by the organic solvent dimethylformamide, and the particles were covalently bonded to the surface of graphene oxide. The morphology of the graphene oxide sheets and ZnO particles was confirmed with field emission scanning electron microscopy and biological atomic force microscopy. Fourier transform infrared spectroscopy and X-ray diffraction were used to analyze the physical and chemical properties of the ZnO/graphene oxide composites that differed from those of the individual components. Enhanced electrochemical properties were detected with cyclic voltammetry, with a redox peak of the composites at 0.025 mV. Excellent antibacterial activity of ZnO/graphene oxide composites was observed with a microdilution method in which minimum inhibitory concentrations of 6.25 µg/mL for Escherichia coli and Salmonella typhimurium, 12.5 µg/mL for Bacillus subtilis, and 25 µg/mL for Enterococcus faecalis. After further study of the antibacterial mechanism, we concluded that a vast number of reactive oxygen species formed on the surface of composites, improving antibacterial properties.

No MeSH data available.


Related in: MedlinePlus

Illustration for the synthesis of the ZnO/graphene oxide composites.Abbreviations: ZnO, zinc oxide; NaOH, sodium hydroxide; APTS, 3-aminopropyltriethoxysilane; DMSO, dimethyl sulfoxide; DMF, dimethylformamide.
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f1-ijn-10-079: Illustration for the synthesis of the ZnO/graphene oxide composites.Abbreviations: ZnO, zinc oxide; NaOH, sodium hydroxide; APTS, 3-aminopropyltriethoxysilane; DMSO, dimethyl sulfoxide; DMF, dimethylformamide.

Mentions: The prepared ZnO (0.50 g) was dissolved in 10 mL DMSO and ultrasonicated for 1 hour. APTS (10 mL) was added to the solution and sonicated for 2 hours to complete the reaction. The amino-functionalized ZnO was separated from the solution via centrifugation, washed with absolute ethanol, and dried in an oven. ZnO-APTS particles (0.10 g) and graphene oxide powder were dissolved in dimethylformamide. The solution was mixed and sonicated for 2 hours to obtain uniform dispersion. Finally, ZnO/graphene oxide composites were recovered via centrifugation and washed three times with alcohol, and dried in an oven for future use. Figure 1 shows the fabrication steps briefly.


Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties.

Zhong L, Yun K - Int J Nanomedicine (2015)

Illustration for the synthesis of the ZnO/graphene oxide composites.Abbreviations: ZnO, zinc oxide; NaOH, sodium hydroxide; APTS, 3-aminopropyltriethoxysilane; DMSO, dimethyl sulfoxide; DMF, dimethylformamide.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554433&req=5

f1-ijn-10-079: Illustration for the synthesis of the ZnO/graphene oxide composites.Abbreviations: ZnO, zinc oxide; NaOH, sodium hydroxide; APTS, 3-aminopropyltriethoxysilane; DMSO, dimethyl sulfoxide; DMF, dimethylformamide.
Mentions: The prepared ZnO (0.50 g) was dissolved in 10 mL DMSO and ultrasonicated for 1 hour. APTS (10 mL) was added to the solution and sonicated for 2 hours to complete the reaction. The amino-functionalized ZnO was separated from the solution via centrifugation, washed with absolute ethanol, and dried in an oven. ZnO-APTS particles (0.10 g) and graphene oxide powder were dissolved in dimethylformamide. The solution was mixed and sonicated for 2 hours to obtain uniform dispersion. Finally, ZnO/graphene oxide composites were recovered via centrifugation and washed three times with alcohol, and dried in an oven for future use. Figure 1 shows the fabrication steps briefly.

Bottom Line: The morphology of the graphene oxide sheets and ZnO particles was confirmed with field emission scanning electron microscopy and biological atomic force microscopy.Enhanced electrochemical properties were detected with cyclic voltammetry, with a redox peak of the composites at 0.025 mV.After further study of the antibacterial mechanism, we concluded that a vast number of reactive oxygen species formed on the surface of composites, improving antibacterial properties.

View Article: PubMed Central - PubMed

Affiliation: Department of Bionanotechnology, Gachon University, Gyeonggi-do, Republic of Korea.

ABSTRACT
Nanosized ZnO particles with diameters of 15 nm were prepared with a solution precipitation method at low cost and high yield. The synthesis of the particles was functionalized by the organic solvent dimethylformamide, and the particles were covalently bonded to the surface of graphene oxide. The morphology of the graphene oxide sheets and ZnO particles was confirmed with field emission scanning electron microscopy and biological atomic force microscopy. Fourier transform infrared spectroscopy and X-ray diffraction were used to analyze the physical and chemical properties of the ZnO/graphene oxide composites that differed from those of the individual components. Enhanced electrochemical properties were detected with cyclic voltammetry, with a redox peak of the composites at 0.025 mV. Excellent antibacterial activity of ZnO/graphene oxide composites was observed with a microdilution method in which minimum inhibitory concentrations of 6.25 µg/mL for Escherichia coli and Salmonella typhimurium, 12.5 µg/mL for Bacillus subtilis, and 25 µg/mL for Enterococcus faecalis. After further study of the antibacterial mechanism, we concluded that a vast number of reactive oxygen species formed on the surface of composites, improving antibacterial properties.

No MeSH data available.


Related in: MedlinePlus