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Current applications of graphene oxide in nanomedicine.

Wu SY, An SS, Hulme J - Int J Nanomedicine (2015)

Bottom Line: Graphene has attracted the attention of the entire scientific community due to its unique mechanical and electrochemical, electronic, biomaterial, and chemical properties.The water-soluble derivative of graphene, graphene oxide, is highly prized and continues to be intensely investigated by scientists around the world.This review seeks to provide an overview of the currents applications of graphene oxide in nanomedicine, focusing on delivery systems, tissue engineering, cancer therapies, imaging, and cytotoxicity, together with a short discussion on the difficulties and the trends for future research regarding this amazing material.

View Article: PubMed Central - PubMed

Affiliation: Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Sungnamsi, Republic of Korea.

ABSTRACT
Graphene has attracted the attention of the entire scientific community due to its unique mechanical and electrochemical, electronic, biomaterial, and chemical properties. The water-soluble derivative of graphene, graphene oxide, is highly prized and continues to be intensely investigated by scientists around the world. This review seeks to provide an overview of the currents applications of graphene oxide in nanomedicine, focusing on delivery systems, tissue engineering, cancer therapies, imaging, and cytotoxicity, together with a short discussion on the difficulties and the trends for future research regarding this amazing material.

No MeSH data available.


A schematic diagram of magnetic resonance (MR)/computed tomography (CT) imaging and near infrared photothermal therapy (PTT) using the graphene oxide/BaGdF5/polyethylene glycol (PEG) nanocomposites. Reproduced with permission from Zhang H, Wu H, Wang J, et al. Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy. Biomaterials. 2015;42:66–77.148 Copyright © 2015 Elsevier.
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f5-ijn-10-009: A schematic diagram of magnetic resonance (MR)/computed tomography (CT) imaging and near infrared photothermal therapy (PTT) using the graphene oxide/BaGdF5/polyethylene glycol (PEG) nanocomposites. Reproduced with permission from Zhang H, Wu H, Wang J, et al. Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy. Biomaterials. 2015;42:66–77.148 Copyright © 2015 Elsevier.

Mentions: MR and X-ray computed tomography (CT) imaging modalities are widely used for various experimental and clinical applications. MR offers high sensitivity and good discrimination particularly in soft tissue but shows no signal for high-density calculus and gland calcification. CT affords better spatial and density resolution than other modalities but is limited by the poor performance of iodine-based CAs in soft tissue. Thus, combining MR imaging with CT modality could achieve more useful information of soft tissues or tumors with enhanced accuracy. Recently, a GO-BaGdF5 nanocomposites148 for multimodal imaging was fabricated using a solvo-thermal method in the presence of PEG; BaGdF5 NPs were firmly attached on the surface of GO nanosheets to form the GO/BaGdF5/PEG. The composite showed low cytotoxicity, positive MR contrast effect, and better X-ray attenuation property than lohexol, which enabled effective dual-modality MR and X-ray CT imaging of a tumor model in vivo. Moreover, histological examination and serum biochemistry assay revealed no apparent toxicity of the CA to mice after treatment. GO/BaGdF5/PEG may be further conjugated with different targeting ligands to construct multifunctional systems for targeted theranosis of cancers. A schematic summarizing the dual-imaging capabilities of GO/BaGdF5/PEG is shown in Figure 5.


Current applications of graphene oxide in nanomedicine.

Wu SY, An SS, Hulme J - Int J Nanomedicine (2015)

A schematic diagram of magnetic resonance (MR)/computed tomography (CT) imaging and near infrared photothermal therapy (PTT) using the graphene oxide/BaGdF5/polyethylene glycol (PEG) nanocomposites. Reproduced with permission from Zhang H, Wu H, Wang J, et al. Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy. Biomaterials. 2015;42:66–77.148 Copyright © 2015 Elsevier.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554423&req=5

f5-ijn-10-009: A schematic diagram of magnetic resonance (MR)/computed tomography (CT) imaging and near infrared photothermal therapy (PTT) using the graphene oxide/BaGdF5/polyethylene glycol (PEG) nanocomposites. Reproduced with permission from Zhang H, Wu H, Wang J, et al. Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy. Biomaterials. 2015;42:66–77.148 Copyright © 2015 Elsevier.
Mentions: MR and X-ray computed tomography (CT) imaging modalities are widely used for various experimental and clinical applications. MR offers high sensitivity and good discrimination particularly in soft tissue but shows no signal for high-density calculus and gland calcification. CT affords better spatial and density resolution than other modalities but is limited by the poor performance of iodine-based CAs in soft tissue. Thus, combining MR imaging with CT modality could achieve more useful information of soft tissues or tumors with enhanced accuracy. Recently, a GO-BaGdF5 nanocomposites148 for multimodal imaging was fabricated using a solvo-thermal method in the presence of PEG; BaGdF5 NPs were firmly attached on the surface of GO nanosheets to form the GO/BaGdF5/PEG. The composite showed low cytotoxicity, positive MR contrast effect, and better X-ray attenuation property than lohexol, which enabled effective dual-modality MR and X-ray CT imaging of a tumor model in vivo. Moreover, histological examination and serum biochemistry assay revealed no apparent toxicity of the CA to mice after treatment. GO/BaGdF5/PEG may be further conjugated with different targeting ligands to construct multifunctional systems for targeted theranosis of cancers. A schematic summarizing the dual-imaging capabilities of GO/BaGdF5/PEG is shown in Figure 5.

Bottom Line: Graphene has attracted the attention of the entire scientific community due to its unique mechanical and electrochemical, electronic, biomaterial, and chemical properties.The water-soluble derivative of graphene, graphene oxide, is highly prized and continues to be intensely investigated by scientists around the world.This review seeks to provide an overview of the currents applications of graphene oxide in nanomedicine, focusing on delivery systems, tissue engineering, cancer therapies, imaging, and cytotoxicity, together with a short discussion on the difficulties and the trends for future research regarding this amazing material.

View Article: PubMed Central - PubMed

Affiliation: Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Sungnamsi, Republic of Korea.

ABSTRACT
Graphene has attracted the attention of the entire scientific community due to its unique mechanical and electrochemical, electronic, biomaterial, and chemical properties. The water-soluble derivative of graphene, graphene oxide, is highly prized and continues to be intensely investigated by scientists around the world. This review seeks to provide an overview of the currents applications of graphene oxide in nanomedicine, focusing on delivery systems, tissue engineering, cancer therapies, imaging, and cytotoxicity, together with a short discussion on the difficulties and the trends for future research regarding this amazing material.

No MeSH data available.