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Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese: Evidence From an Updated Meta-Analysis of 27 Studies.

Zhang M, Tan X, Huang J, Ke Z, Ge Y, Xiong H, Lu W, Fang L, Cai Z, Wu S - Med. Sci. Monit. (2015)

Bottom Line: Nevertheless, the data arising from these studies were inconclusive.We used odds ratios (ORs) corresponding with 95% confidence intervals (CIs) by using the random/fixed-effects model to evaluate the association.Moreover, in the stratification analysis by genotyping method, we identified an increased susceptibility for PCR-RFLP group in rs17855750 polymorphism, whereas a decreased susceptibility was identified in rs153109 polymorphism.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).

ABSTRACT

Background: Many epidemiology studies have indicated that several functional polymorphisms of the IL-27 gene may contribute to individual susceptibility to cancer. Nevertheless, the data arising from these studies were inconclusive. Therefore, we conducted the current meta-analysis aiming to elucidate the effects of IL-27 polymorphisms (rs153109, rs17855750, and rs181206) on cancer susceptibility.

Material and methods: We searched the CNKI (Chinese National Knowledge Infrastructure), Wanfang database, PubMed, Web of Science, and Google Scholar for all eligible publications. We used odds ratios (ORs) corresponding with 95% confidence intervals (CIs) by using the random/fixed-effects model to evaluate the association. Finally, a total of 12 publications, including 27 case-control studies comprising of 7570 patients and 9839 controls, were enrolled in our meta-analysis.

Results: Our work demonstrates that IL-27 rs17855750 polymorphism is significantly associated with cancer susceptibility, particularly for bladder cancer. However, no association between IL-27 rs153109 and rs181206 polymorphisms and cancer susceptibility was identified. When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism. Moreover, in the stratification analysis by genotyping method, we identified an increased susceptibility for PCR-RFLP group in rs17855750 polymorphism, whereas a decreased susceptibility was identified in rs153109 polymorphism.

Conclusions: Our study shows that IL-27 rs17855750 polymorphism is significantly associated with increased susceptibility to cancer in Chinese.

No MeSH data available.


Related in: MedlinePlus

(A) Publication bias in studies of the association between the IL-27 rs153109 polymorphism and cancer susceptibility assessed by Begg’s funnel plot and Egger’s test (G vs. A). Log (OR): the natural logarithm of the odds ratio. (B) Publication bias in studies of the association between the IL-27 rs181206 polymorphism and cancer risk assessed by Begg’s funnel plot and Egger’s test (C vs. T). Log (OR): the natural logarithm of the odds ratio. (C) Publication bias in studies of the association between the IL-27 rs17855750 polymorphism and cancer susceptibility assessed by Begg’s funnel plot and Egger’s test (G vs. T). Log (OR): the natural logarithm of the odds ratio.
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f4-medscimonit-21-2505: (A) Publication bias in studies of the association between the IL-27 rs153109 polymorphism and cancer susceptibility assessed by Begg’s funnel plot and Egger’s test (G vs. A). Log (OR): the natural logarithm of the odds ratio. (B) Publication bias in studies of the association between the IL-27 rs181206 polymorphism and cancer risk assessed by Begg’s funnel plot and Egger’s test (C vs. T). Log (OR): the natural logarithm of the odds ratio. (C) Publication bias in studies of the association between the IL-27 rs17855750 polymorphism and cancer susceptibility assessed by Begg’s funnel plot and Egger’s test (G vs. T). Log (OR): the natural logarithm of the odds ratio.

Mentions: We performed sensitivity analysis by omitting each study sequentially, suggesting that the results for the overall population were statistically robust and reliable (Figure 3A–3C). Egger’s test and Begg’s funnel plot were performed to examine the publication bias risk in our research. No publication bias was identified (rs153109: G vs. A: P=0.300 for Begg’s test, P=0.112 for Egger’s test, Figure 4A; rs181206: C vs. T: P=0.133 for Begg’s test, P=0.252 for Egger’s test; Figure 4B; rs17855750: G vs. T: P=0.283 for Begg’s test, P=0.322 for Egger’s test; Figure 4C).


Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese: Evidence From an Updated Meta-Analysis of 27 Studies.

Zhang M, Tan X, Huang J, Ke Z, Ge Y, Xiong H, Lu W, Fang L, Cai Z, Wu S - Med. Sci. Monit. (2015)

(A) Publication bias in studies of the association between the IL-27 rs153109 polymorphism and cancer susceptibility assessed by Begg’s funnel plot and Egger’s test (G vs. A). Log (OR): the natural logarithm of the odds ratio. (B) Publication bias in studies of the association between the IL-27 rs181206 polymorphism and cancer risk assessed by Begg’s funnel plot and Egger’s test (C vs. T). Log (OR): the natural logarithm of the odds ratio. (C) Publication bias in studies of the association between the IL-27 rs17855750 polymorphism and cancer susceptibility assessed by Begg’s funnel plot and Egger’s test (G vs. T). Log (OR): the natural logarithm of the odds ratio.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4554366&req=5

f4-medscimonit-21-2505: (A) Publication bias in studies of the association between the IL-27 rs153109 polymorphism and cancer susceptibility assessed by Begg’s funnel plot and Egger’s test (G vs. A). Log (OR): the natural logarithm of the odds ratio. (B) Publication bias in studies of the association between the IL-27 rs181206 polymorphism and cancer risk assessed by Begg’s funnel plot and Egger’s test (C vs. T). Log (OR): the natural logarithm of the odds ratio. (C) Publication bias in studies of the association between the IL-27 rs17855750 polymorphism and cancer susceptibility assessed by Begg’s funnel plot and Egger’s test (G vs. T). Log (OR): the natural logarithm of the odds ratio.
Mentions: We performed sensitivity analysis by omitting each study sequentially, suggesting that the results for the overall population were statistically robust and reliable (Figure 3A–3C). Egger’s test and Begg’s funnel plot were performed to examine the publication bias risk in our research. No publication bias was identified (rs153109: G vs. A: P=0.300 for Begg’s test, P=0.112 for Egger’s test, Figure 4A; rs181206: C vs. T: P=0.133 for Begg’s test, P=0.252 for Egger’s test; Figure 4B; rs17855750: G vs. T: P=0.283 for Begg’s test, P=0.322 for Egger’s test; Figure 4C).

Bottom Line: Nevertheless, the data arising from these studies were inconclusive.We used odds ratios (ORs) corresponding with 95% confidence intervals (CIs) by using the random/fixed-effects model to evaluate the association.Moreover, in the stratification analysis by genotyping method, we identified an increased susceptibility for PCR-RFLP group in rs17855750 polymorphism, whereas a decreased susceptibility was identified in rs153109 polymorphism.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).

ABSTRACT

Background: Many epidemiology studies have indicated that several functional polymorphisms of the IL-27 gene may contribute to individual susceptibility to cancer. Nevertheless, the data arising from these studies were inconclusive. Therefore, we conducted the current meta-analysis aiming to elucidate the effects of IL-27 polymorphisms (rs153109, rs17855750, and rs181206) on cancer susceptibility.

Material and methods: We searched the CNKI (Chinese National Knowledge Infrastructure), Wanfang database, PubMed, Web of Science, and Google Scholar for all eligible publications. We used odds ratios (ORs) corresponding with 95% confidence intervals (CIs) by using the random/fixed-effects model to evaluate the association. Finally, a total of 12 publications, including 27 case-control studies comprising of 7570 patients and 9839 controls, were enrolled in our meta-analysis.

Results: Our work demonstrates that IL-27 rs17855750 polymorphism is significantly associated with cancer susceptibility, particularly for bladder cancer. However, no association between IL-27 rs153109 and rs181206 polymorphisms and cancer susceptibility was identified. When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism. Moreover, in the stratification analysis by genotyping method, we identified an increased susceptibility for PCR-RFLP group in rs17855750 polymorphism, whereas a decreased susceptibility was identified in rs153109 polymorphism.

Conclusions: Our study shows that IL-27 rs17855750 polymorphism is significantly associated with increased susceptibility to cancer in Chinese.

No MeSH data available.


Related in: MedlinePlus