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Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese: Evidence From an Updated Meta-Analysis of 27 Studies.

Zhang M, Tan X, Huang J, Ke Z, Ge Y, Xiong H, Lu W, Fang L, Cai Z, Wu S - Med. Sci. Monit. (2015)

Bottom Line: Nevertheless, the data arising from these studies were inconclusive.We used odds ratios (ORs) corresponding with 95% confidence intervals (CIs) by using the random/fixed-effects model to evaluate the association.Moreover, in the stratification analysis by genotyping method, we identified an increased susceptibility for PCR-RFLP group in rs17855750 polymorphism, whereas a decreased susceptibility was identified in rs153109 polymorphism.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).

ABSTRACT

Background: Many epidemiology studies have indicated that several functional polymorphisms of the IL-27 gene may contribute to individual susceptibility to cancer. Nevertheless, the data arising from these studies were inconclusive. Therefore, we conducted the current meta-analysis aiming to elucidate the effects of IL-27 polymorphisms (rs153109, rs17855750, and rs181206) on cancer susceptibility.

Material and methods: We searched the CNKI (Chinese National Knowledge Infrastructure), Wanfang database, PubMed, Web of Science, and Google Scholar for all eligible publications. We used odds ratios (ORs) corresponding with 95% confidence intervals (CIs) by using the random/fixed-effects model to evaluate the association. Finally, a total of 12 publications, including 27 case-control studies comprising of 7570 patients and 9839 controls, were enrolled in our meta-analysis.

Results: Our work demonstrates that IL-27 rs17855750 polymorphism is significantly associated with cancer susceptibility, particularly for bladder cancer. However, no association between IL-27 rs153109 and rs181206 polymorphisms and cancer susceptibility was identified. When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism. Moreover, in the stratification analysis by genotyping method, we identified an increased susceptibility for PCR-RFLP group in rs17855750 polymorphism, whereas a decreased susceptibility was identified in rs153109 polymorphism.

Conclusions: Our study shows that IL-27 rs17855750 polymorphism is significantly associated with increased susceptibility to cancer in Chinese.

No MeSH data available.


Related in: MedlinePlus

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f1-medscimonit-21-2505: The flow chart presenting the publications selecting procedure.

Mentions: As presented in Figure 1, after a systematic literature search in the databases, 46 potential relevant studies on the association between IL-27 polymorphisms and cancer were identified. Nevertheless, of them, 34 were unqualified in that some were based on case-only design, some were not polymorphism studies and the others were not concerning the susceptibility of cancer. In the end, a total of 12 publications with 27 independent case-control studies comprising of 7,570 cases and 9,839 controls were concerning the associations of IL-27 polymorphisms and cancer susceptibility. The characteristics of enrolled studies were presented in Table 1 [8–13,22–27]. The genotype distributions of the three polymorphisms and the genotyping method of the enrolled studies were retrieved scrupulously, and the controls were selected from non-cancer populations. Additionally, there were three case-control studies deviated from HWE [13,23].


Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese: Evidence From an Updated Meta-Analysis of 27 Studies.

Zhang M, Tan X, Huang J, Ke Z, Ge Y, Xiong H, Lu W, Fang L, Cai Z, Wu S - Med. Sci. Monit. (2015)

The flow chart presenting the publications selecting procedure.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4554366&req=5

f1-medscimonit-21-2505: The flow chart presenting the publications selecting procedure.
Mentions: As presented in Figure 1, after a systematic literature search in the databases, 46 potential relevant studies on the association between IL-27 polymorphisms and cancer were identified. Nevertheless, of them, 34 were unqualified in that some were based on case-only design, some were not polymorphism studies and the others were not concerning the susceptibility of cancer. In the end, a total of 12 publications with 27 independent case-control studies comprising of 7,570 cases and 9,839 controls were concerning the associations of IL-27 polymorphisms and cancer susceptibility. The characteristics of enrolled studies were presented in Table 1 [8–13,22–27]. The genotype distributions of the three polymorphisms and the genotyping method of the enrolled studies were retrieved scrupulously, and the controls were selected from non-cancer populations. Additionally, there were three case-control studies deviated from HWE [13,23].

Bottom Line: Nevertheless, the data arising from these studies were inconclusive.We used odds ratios (ORs) corresponding with 95% confidence intervals (CIs) by using the random/fixed-effects model to evaluate the association.Moreover, in the stratification analysis by genotyping method, we identified an increased susceptibility for PCR-RFLP group in rs17855750 polymorphism, whereas a decreased susceptibility was identified in rs153109 polymorphism.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).

ABSTRACT

Background: Many epidemiology studies have indicated that several functional polymorphisms of the IL-27 gene may contribute to individual susceptibility to cancer. Nevertheless, the data arising from these studies were inconclusive. Therefore, we conducted the current meta-analysis aiming to elucidate the effects of IL-27 polymorphisms (rs153109, rs17855750, and rs181206) on cancer susceptibility.

Material and methods: We searched the CNKI (Chinese National Knowledge Infrastructure), Wanfang database, PubMed, Web of Science, and Google Scholar for all eligible publications. We used odds ratios (ORs) corresponding with 95% confidence intervals (CIs) by using the random/fixed-effects model to evaluate the association. Finally, a total of 12 publications, including 27 case-control studies comprising of 7570 patients and 9839 controls, were enrolled in our meta-analysis.

Results: Our work demonstrates that IL-27 rs17855750 polymorphism is significantly associated with cancer susceptibility, particularly for bladder cancer. However, no association between IL-27 rs153109 and rs181206 polymorphisms and cancer susceptibility was identified. When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism. Moreover, in the stratification analysis by genotyping method, we identified an increased susceptibility for PCR-RFLP group in rs17855750 polymorphism, whereas a decreased susceptibility was identified in rs153109 polymorphism.

Conclusions: Our study shows that IL-27 rs17855750 polymorphism is significantly associated with increased susceptibility to cancer in Chinese.

No MeSH data available.


Related in: MedlinePlus