Limits...
Relationship between female hormonal and menstrual factors and pancreatic cancer: a meta-analysis of observational studies.

Tang B, Lv J, Li Y, Yuan S, Wang Z, He S - Medicine (Baltimore) (2015)

Bottom Line: Combined relative risks (RRs) were estimated by random-effects models.Sensitivity analyses and publication bias were utilized to evaluate the robustness of our results.No significant associations were observed between the risk of PC and age at menarche (RR = 0.94, 95% confidence interval [CI] 0.83-1.07), age at menopause (RR = 0.98, 95% CI 0.85-1.13), hysterectomy (RR = 0.97, 95% CI 0.84-1.11), oophorectomy (RR = 1.02, 95% CI 0.82-1.26), hormone replacement therapy (RR = 0.97, 95% CI 0.87-1.08), and oral contraceptives (RR = 1.09, 95% CI 0.96-1.23).

View Article: PubMed Central - PubMed

Affiliation: From the Department of Hepatobiliary Surgery (BT, SY, ZW, SH), Affiliated Hospital of Guilin Medical University; Laboratory of Liver Injury and Repair Molecular Medicine (BT, SH), Guilin Medical University, Guilin; Department of Infectious Diseases (JL), People's Hospital of Beihai, Beihai; and Department of Medical Oncology (YL), Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, People's Republic of China.

ABSTRACT
The objective of this study was to assess the relationship between female hormone and menstrual factors and pancreatic cancer (PC) through a meta-analysis of observational studies. We undertook a systematic literature search up to July 10, 2014 in PubMed and EMBASE databases. Combined relative risks (RRs) were estimated by random-effects models. Subgroup analysis was performed by study design, source of control, and geographic regions. Sensitivity analyses and publication bias were utilized to evaluate the robustness of our results. A total of 27 case-control and cohort studies were retrieved for this meta-analysis. No significant associations were observed between the risk of PC and age at menarche (RR = 0.94, 95% confidence interval [CI] 0.83-1.07), age at menopause (RR = 0.98, 95% CI 0.85-1.13), hysterectomy (RR = 0.97, 95% CI 0.84-1.11), oophorectomy (RR = 1.02, 95% CI 0.82-1.26), hormone replacement therapy (RR = 0.97, 95% CI 0.87-1.08), and oral contraceptives (RR = 1.09, 95% CI 0.96-1.23). This meta-analysis of observational studies does not support the hypothesis that exogenous hormone use and menstrual factors are associated with PC.

Show MeSH

Related in: MedlinePlus

Flow diagram of literature search and selection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4554173&req=5

Figure 1: Flow diagram of literature search and selection.

Mentions: Figure 1 shows the process used for the literature search and study selection. A total of 441 publications were identified from databases. Seven studies were additionally identified from the references of other relevant studies. To begin with, 122 duplicate records were excluded. Next, we reviewed the titles and abstracts, and 285 articles were further removed. Finally, 41 articles with full-text were assessed for eligibility. Of these 41 articles, 14 were further excluded because they provided insufficient data,46 were reviews or meta-analysis,3,10,11,47,48 involved parity,49–53 and had overlapping data.54–56 Thus, in total, 27 articles listed in Table 1 were included in the present analysis.4,13–38 All studies were published in English. The first study dated back to 1966. The latest article was published in 2013. Fourteen of 27 studies were case–control studies,13–19,22,23,25,29,34,36,37 the remainders were cohort studies.4,20,21,24,26–28,30–33,35,38 In 7 of case–control studies, controls were recruited randomly from hospitals in 3 studies;13–15,18,29,36,37 in the other 7, they were drawn from the general population.16,17,19,22,23,25,34 All studies were published in Western countries except 2 from East Asia and 1 from Africa.19,28,29 Cases were ascertained by means of computerized record linkages to cancer registries, histopathology, and medical records (eg, health insurance records, death certificates, radiological images). Assessment tools to collect data on exposure variables consisted of interviewer-administered questionnaire, self-administered questionnaire, prescription registry, hospital records, and mass screening registry.


Relationship between female hormonal and menstrual factors and pancreatic cancer: a meta-analysis of observational studies.

Tang B, Lv J, Li Y, Yuan S, Wang Z, He S - Medicine (Baltimore) (2015)

Flow diagram of literature search and selection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554173&req=5

Figure 1: Flow diagram of literature search and selection.
Mentions: Figure 1 shows the process used for the literature search and study selection. A total of 441 publications were identified from databases. Seven studies were additionally identified from the references of other relevant studies. To begin with, 122 duplicate records were excluded. Next, we reviewed the titles and abstracts, and 285 articles were further removed. Finally, 41 articles with full-text were assessed for eligibility. Of these 41 articles, 14 were further excluded because they provided insufficient data,46 were reviews or meta-analysis,3,10,11,47,48 involved parity,49–53 and had overlapping data.54–56 Thus, in total, 27 articles listed in Table 1 were included in the present analysis.4,13–38 All studies were published in English. The first study dated back to 1966. The latest article was published in 2013. Fourteen of 27 studies were case–control studies,13–19,22,23,25,29,34,36,37 the remainders were cohort studies.4,20,21,24,26–28,30–33,35,38 In 7 of case–control studies, controls were recruited randomly from hospitals in 3 studies;13–15,18,29,36,37 in the other 7, they were drawn from the general population.16,17,19,22,23,25,34 All studies were published in Western countries except 2 from East Asia and 1 from Africa.19,28,29 Cases were ascertained by means of computerized record linkages to cancer registries, histopathology, and medical records (eg, health insurance records, death certificates, radiological images). Assessment tools to collect data on exposure variables consisted of interviewer-administered questionnaire, self-administered questionnaire, prescription registry, hospital records, and mass screening registry.

Bottom Line: Combined relative risks (RRs) were estimated by random-effects models.Sensitivity analyses and publication bias were utilized to evaluate the robustness of our results.No significant associations were observed between the risk of PC and age at menarche (RR = 0.94, 95% confidence interval [CI] 0.83-1.07), age at menopause (RR = 0.98, 95% CI 0.85-1.13), hysterectomy (RR = 0.97, 95% CI 0.84-1.11), oophorectomy (RR = 1.02, 95% CI 0.82-1.26), hormone replacement therapy (RR = 0.97, 95% CI 0.87-1.08), and oral contraceptives (RR = 1.09, 95% CI 0.96-1.23).

View Article: PubMed Central - PubMed

Affiliation: From the Department of Hepatobiliary Surgery (BT, SY, ZW, SH), Affiliated Hospital of Guilin Medical University; Laboratory of Liver Injury and Repair Molecular Medicine (BT, SH), Guilin Medical University, Guilin; Department of Infectious Diseases (JL), People's Hospital of Beihai, Beihai; and Department of Medical Oncology (YL), Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, People's Republic of China.

ABSTRACT
The objective of this study was to assess the relationship between female hormone and menstrual factors and pancreatic cancer (PC) through a meta-analysis of observational studies. We undertook a systematic literature search up to July 10, 2014 in PubMed and EMBASE databases. Combined relative risks (RRs) were estimated by random-effects models. Subgroup analysis was performed by study design, source of control, and geographic regions. Sensitivity analyses and publication bias were utilized to evaluate the robustness of our results. A total of 27 case-control and cohort studies were retrieved for this meta-analysis. No significant associations were observed between the risk of PC and age at menarche (RR = 0.94, 95% confidence interval [CI] 0.83-1.07), age at menopause (RR = 0.98, 95% CI 0.85-1.13), hysterectomy (RR = 0.97, 95% CI 0.84-1.11), oophorectomy (RR = 1.02, 95% CI 0.82-1.26), hormone replacement therapy (RR = 0.97, 95% CI 0.87-1.08), and oral contraceptives (RR = 1.09, 95% CI 0.96-1.23). This meta-analysis of observational studies does not support the hypothesis that exogenous hormone use and menstrual factors are associated with PC.

Show MeSH
Related in: MedlinePlus