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Association between periodontal disease and osteoporosis by gender: a nationwide population-based cohort study.

Lin TH, Lung CC, Su HP, Huang JY, Ko PC, Jan SR, Sun YH, Nfor ON, Tu HP, Chang CS, Jian ZH, Chiang YC, Liaw YP - Medicine (Baltimore) (2015)

Bottom Line: Multiple logistic regression was used for analysis.After adjusting for age, sex, income, and geographical region, there was a significant association between periodontitis and osteoporosis among women (odds ratio: 1.96; 95% confidence interval 1.17-3.26).The association between periodontitis and osteoporosis was significant among women.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Dental Hygiene (THL, HPS, HPT), China Medical University; Department of Public Health and Institute of Public Health (CCL, JYH, PCK, SRJ, YHS, ONN, ZHJ, YCC, YPL), Chung Shan Medical University; Department of Family and Community Medicine (CCL, YCC, YPL); Department of Dentistry (YHS), Chung Shan Medical University, Taichung; and Taiwan Society of Oral Health (CSC), Keelung, Taiwan.

ABSTRACT
Periodontitis and osteoporosis are primary concerns in public health and clinical management. The aim of this study was to investigate the association between periodontitis and osteoporosis by gender.Data were retrieved from the National Health Insurance Research Database, Taiwan. A diagnosis of periodontitis was defined on the basis of subgingival curettage, periodontal flap operation, and gingivectomy (excluding those with restorative or aesthetic indications). Multiple logistic regression was used for analysis. After adjusting for age, sex, income, and geographical region, there was a significant association between periodontitis and osteoporosis among women (odds ratio: 1.96; 95% confidence interval 1.17-3.26). The association between periodontitis and osteoporosis was significant among women.

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Related in: MedlinePlus

Flow chart of subjects selected from the National Health Insurance Research Database.
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Figure 1: Flow chart of subjects selected from the National Health Insurance Research Database.

Mentions: A total of 1,878,401 individuals were sampled (Figure 1). In general, 4535 women and 4770 men were diagnosed with periodontal diseases from 2001 to 2003, and 1266 women and 243 men were diagnosed with osteoporosis from 2004 to 2010. Among the periodontal disease cohorts, 15 women and 4 men were diagnosed with osteoporosis. Osteoporotic individuals had a significantly higher mean age (65.81, n = 1509) than their nonosteoporotic counterparts (35.03, n = 1,876,892, P < 0.0001) as shown in Table 2. Variables such as sex, insurance amount, geographical region, and periodontal disease were significantly different between osteoporotic and nonosteoporotic individuals (Table 2). Results from multiple logistic regressions are shown in Table 3. The risk for osteoporosis was higher among patients who received periodontal treatment (odds ratio [OR]: 2.30; 95% confidence interval [CI] 1.29–3.20). Tables 4 and 5 show the OR of osteoporosis categorized by sex. The risk of developing osteoporosis was more significant among women (OR: 1.96; 95% CI 1.17–3.26) than men (OR: 2.37; 95% CI 0.88–6.39).


Association between periodontal disease and osteoporosis by gender: a nationwide population-based cohort study.

Lin TH, Lung CC, Su HP, Huang JY, Ko PC, Jan SR, Sun YH, Nfor ON, Tu HP, Chang CS, Jian ZH, Chiang YC, Liaw YP - Medicine (Baltimore) (2015)

Flow chart of subjects selected from the National Health Insurance Research Database.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554172&req=5

Figure 1: Flow chart of subjects selected from the National Health Insurance Research Database.
Mentions: A total of 1,878,401 individuals were sampled (Figure 1). In general, 4535 women and 4770 men were diagnosed with periodontal diseases from 2001 to 2003, and 1266 women and 243 men were diagnosed with osteoporosis from 2004 to 2010. Among the periodontal disease cohorts, 15 women and 4 men were diagnosed with osteoporosis. Osteoporotic individuals had a significantly higher mean age (65.81, n = 1509) than their nonosteoporotic counterparts (35.03, n = 1,876,892, P < 0.0001) as shown in Table 2. Variables such as sex, insurance amount, geographical region, and periodontal disease were significantly different between osteoporotic and nonosteoporotic individuals (Table 2). Results from multiple logistic regressions are shown in Table 3. The risk for osteoporosis was higher among patients who received periodontal treatment (odds ratio [OR]: 2.30; 95% confidence interval [CI] 1.29–3.20). Tables 4 and 5 show the OR of osteoporosis categorized by sex. The risk of developing osteoporosis was more significant among women (OR: 1.96; 95% CI 1.17–3.26) than men (OR: 2.37; 95% CI 0.88–6.39).

Bottom Line: Multiple logistic regression was used for analysis.After adjusting for age, sex, income, and geographical region, there was a significant association between periodontitis and osteoporosis among women (odds ratio: 1.96; 95% confidence interval 1.17-3.26).The association between periodontitis and osteoporosis was significant among women.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Dental Hygiene (THL, HPS, HPT), China Medical University; Department of Public Health and Institute of Public Health (CCL, JYH, PCK, SRJ, YHS, ONN, ZHJ, YCC, YPL), Chung Shan Medical University; Department of Family and Community Medicine (CCL, YCC, YPL); Department of Dentistry (YHS), Chung Shan Medical University, Taichung; and Taiwan Society of Oral Health (CSC), Keelung, Taiwan.

ABSTRACT
Periodontitis and osteoporosis are primary concerns in public health and clinical management. The aim of this study was to investigate the association between periodontitis and osteoporosis by gender.Data were retrieved from the National Health Insurance Research Database, Taiwan. A diagnosis of periodontitis was defined on the basis of subgingival curettage, periodontal flap operation, and gingivectomy (excluding those with restorative or aesthetic indications). Multiple logistic regression was used for analysis. After adjusting for age, sex, income, and geographical region, there was a significant association between periodontitis and osteoporosis among women (odds ratio: 1.96; 95% confidence interval 1.17-3.26). The association between periodontitis and osteoporosis was significant among women.

Show MeSH
Related in: MedlinePlus