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Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk: A Meta Analysis.

Wang H, Zhang K, Qin H, Yang L, Zhang L, Cao Y - Medicine (Baltimore) (2015)

Bottom Line: rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia.The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis.A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19-2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08-1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06-2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.

View Article: PubMed Central - PubMed

Affiliation: Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.

ABSTRACT
rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia. There have been different reports regarding the correlation of CD143 rs4340 genotypes with pneumonia risk, which prompted us to perform a meta-analysis to determine the elusive association.We combined multiple keywords to identify the studies addressing the association between CD143 rs4340 genotypes and pneumonia risk covered in the EMBASE, Google Scholar, PubMed, and CNKI databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the risk of pneumonia. The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis. We found a strong association between rs4340 single nucleotide polymorphism (SNP) and pneumonia risk using the recessive model (FEM: OR 1.33, 95% CI 1.13-1.57). A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19-2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08-1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06-2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.

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Related in: MedlinePlus

Funnel plots of the Egger test of CD143 rs4340 polymorphism for publication bias. CI =  confidence interval, OR = odds ratio.
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Figure 3: Funnel plots of the Egger test of CD143 rs4340 polymorphism for publication bias. CI =  confidence interval, OR = odds ratio.

Mentions: In the funnel plots for each genetic model, the studies were symmetrically distributed. When performing the Egger test, we found little evidence of significant publication bias across studies (Begg, P = 0.721; Egger, P = 0.975, the recessive model) (Figure 3).


Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk: A Meta Analysis.

Wang H, Zhang K, Qin H, Yang L, Zhang L, Cao Y - Medicine (Baltimore) (2015)

Funnel plots of the Egger test of CD143 rs4340 polymorphism for publication bias. CI =  confidence interval, OR = odds ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554131&req=5

Figure 3: Funnel plots of the Egger test of CD143 rs4340 polymorphism for publication bias. CI =  confidence interval, OR = odds ratio.
Mentions: In the funnel plots for each genetic model, the studies were symmetrically distributed. When performing the Egger test, we found little evidence of significant publication bias across studies (Begg, P = 0.721; Egger, P = 0.975, the recessive model) (Figure 3).

Bottom Line: rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia.The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis.A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19-2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08-1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06-2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.

View Article: PubMed Central - PubMed

Affiliation: Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.

ABSTRACT
rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia. There have been different reports regarding the correlation of CD143 rs4340 genotypes with pneumonia risk, which prompted us to perform a meta-analysis to determine the elusive association.We combined multiple keywords to identify the studies addressing the association between CD143 rs4340 genotypes and pneumonia risk covered in the EMBASE, Google Scholar, PubMed, and CNKI databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the risk of pneumonia. The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis. We found a strong association between rs4340 single nucleotide polymorphism (SNP) and pneumonia risk using the recessive model (FEM: OR 1.33, 95% CI 1.13-1.57). A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19-2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08-1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06-2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.

Show MeSH
Related in: MedlinePlus