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Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk: A Meta Analysis.

Wang H, Zhang K, Qin H, Yang L, Zhang L, Cao Y - Medicine (Baltimore) (2015)

Bottom Line: rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia.The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis.A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19-2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08-1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06-2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.

View Article: PubMed Central - PubMed

Affiliation: Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.

ABSTRACT
rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia. There have been different reports regarding the correlation of CD143 rs4340 genotypes with pneumonia risk, which prompted us to perform a meta-analysis to determine the elusive association.We combined multiple keywords to identify the studies addressing the association between CD143 rs4340 genotypes and pneumonia risk covered in the EMBASE, Google Scholar, PubMed, and CNKI databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the risk of pneumonia. The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis. We found a strong association between rs4340 single nucleotide polymorphism (SNP) and pneumonia risk using the recessive model (FEM: OR 1.33, 95% CI 1.13-1.57). A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19-2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08-1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06-2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.

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The flow chart of the included studies for a meta-analysis of CD143 rs4340 polymorphism and pneumonia risk.
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Figure 1: The flow chart of the included studies for a meta-analysis of CD143 rs4340 polymorphism and pneumonia risk.

Mentions: As depicted in Figure 1, 215 potentially relevant studies were identified through electronic databases and other sources. Among these, 203 studies were excluded owing to research concerning use of CD143 inhibitors or serum CD143 levels and pneumonia risk, or subjects unrelated to the polymorphism of interest. After reading the full texts of the remaining articles, we further excluded 2 studies, of which 1 was a case-only study,22 and the other was a duplicate of 2 studies analyzed in the present analysis.23 Therefore, 10 original articles concerning the correlation of rs4340 SNP with pneumonia were considered eligible for this analysis.15,16,24–31 Main characteristics, including first author, publication year, study country, ethnicity of the populations included, assays used in determining rs4340 SNP, source of controls, specific type of pneumonia, and sample size are presented in Table 1. The 10 studies from 6 different countries were composed of 4 Caucasian studies, 5 Asian studies, and 1 study without stating the ethnicity. In addition, 7 groups studied CAP, 2 studied NP (Takahashi et al presented data in forms of D/D, I/D + I/I, so this study was only available for the recessive model), and 1 study did not give any information on which type of pneumonia was studied. All genotype frequencies were in HWE with the exception of Gu et al (P < 0.001).


Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk: A Meta Analysis.

Wang H, Zhang K, Qin H, Yang L, Zhang L, Cao Y - Medicine (Baltimore) (2015)

The flow chart of the included studies for a meta-analysis of CD143 rs4340 polymorphism and pneumonia risk.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554131&req=5

Figure 1: The flow chart of the included studies for a meta-analysis of CD143 rs4340 polymorphism and pneumonia risk.
Mentions: As depicted in Figure 1, 215 potentially relevant studies were identified through electronic databases and other sources. Among these, 203 studies were excluded owing to research concerning use of CD143 inhibitors or serum CD143 levels and pneumonia risk, or subjects unrelated to the polymorphism of interest. After reading the full texts of the remaining articles, we further excluded 2 studies, of which 1 was a case-only study,22 and the other was a duplicate of 2 studies analyzed in the present analysis.23 Therefore, 10 original articles concerning the correlation of rs4340 SNP with pneumonia were considered eligible for this analysis.15,16,24–31 Main characteristics, including first author, publication year, study country, ethnicity of the populations included, assays used in determining rs4340 SNP, source of controls, specific type of pneumonia, and sample size are presented in Table 1. The 10 studies from 6 different countries were composed of 4 Caucasian studies, 5 Asian studies, and 1 study without stating the ethnicity. In addition, 7 groups studied CAP, 2 studied NP (Takahashi et al presented data in forms of D/D, I/D + I/I, so this study was only available for the recessive model), and 1 study did not give any information on which type of pneumonia was studied. All genotype frequencies were in HWE with the exception of Gu et al (P < 0.001).

Bottom Line: rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia.The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis.A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19-2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08-1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06-2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.

View Article: PubMed Central - PubMed

Affiliation: Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.

ABSTRACT
rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia. There have been different reports regarding the correlation of CD143 rs4340 genotypes with pneumonia risk, which prompted us to perform a meta-analysis to determine the elusive association.We combined multiple keywords to identify the studies addressing the association between CD143 rs4340 genotypes and pneumonia risk covered in the EMBASE, Google Scholar, PubMed, and CNKI databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the risk of pneumonia. The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis. We found a strong association between rs4340 single nucleotide polymorphism (SNP) and pneumonia risk using the recessive model (FEM: OR 1.33, 95% CI 1.13-1.57). A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19-2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08-1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06-2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.

Show MeSH
Related in: MedlinePlus