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The risk of erectile dysfunction in chronic obstructive pulmonary disease: a population-based cohort study in Taiwan.

Shen TC, Chen WC, Lin CL, Chen CH, Tu CY, Hsia TC, Shih CM, Hsu WH, Sung FC - Medicine (Baltimore) (2015)

Bottom Line: Patients were recruited between 2000 and 2011, and the date of diagnosis was defined as the index date.The hazard ratios of ED were estimated using the Cox proportional hazard model after adjusting for age, index year, comorbidities, and medications.Patients with COPD are at a significantly higher risk of developing ED compared with the general population regardless of age and presence of comorbidity.

View Article: PubMed Central - PubMed

Affiliation: From the Graduate Institute of Clinical Medicine Science (T-CS, C-HC, F-CS), College of Medicine; Division of Pulmonary and Critical Care Medicine (T-CS, C-HC, C-YT, T-CH, C-MS, W-HH), Department of Internal Medicine, China Medical University Hospital, Taichung; Division of Pulmonary and Critical Care Medicine (T-CS), Department of Internal Medicine, Chu Shang Show Chwan Hospital, Nantou; Department of Urology (W-CC); Management Office for Health Data (C-LL), China Medical University Hospital, Taichung, Taiwan.

ABSTRACT
The prevalence of erectile dysfunction (ED) in patients with chronic obstructive pulmonary disease (COPD) seemed high; however, large scale of population-based study was absent. We conducted a retrospective cohort study using data from the National Health Insurance system of Taiwan. The cohort included 29,042 male patients who were newly diagnosed with COPD. Patients were recruited between 2000 and 2011, and the date of diagnosis was defined as the index date. Each patient was randomly matched with 1 male person from the general population without COPD according to age and the index year. The occurrence of ED was followed up until the end of 2011. The hazard ratios of ED were estimated using the Cox proportional hazard model after adjusting for age, index year, comorbidities, and medications. The overall incidence of ED was 1.88-fold greater in the COPD cohort than in the non-COPD cohort (24.9 vs 13.3/1000 person-years, 95% confidence interval [CI] = 1.61-2.18). Compared with non-COPD patients, the hazard ratio increased with the number of emergency room visits and admissions for COPD from 1.51 (95% CI 1.29-1.77) to 5.46 (95% CI 3.03-9.84) and from 1.50 (95% CI 1.28-1.76) to 11.5 (95% CI 5.83-22.6), respectively. Patients with COPD are at a significantly higher risk of developing ED compared with the general population regardless of age and presence of comorbidity. The results also support that poor control of COPD status is a key factor affecting ED development.

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Related in: MedlinePlus

Cumulative incidence of ED in patients with (dashed line) or without (solid line) COPD. COPD = chronic obstructive pulmonary disease, ED = erectile dysfunction.
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Figure 1: Cumulative incidence of ED in patients with (dashed line) or without (solid line) COPD. COPD = chronic obstructive pulmonary disease, ED = erectile dysfunction.

Mentions: Overall, 57,928 subjects were selected for this retrospective cohort study, including 29,042 COPD patients and 28,886 non-COPD controls. The age distribution was similar in both cohorts, with the mean age slightly higher in the COPD cohort than in the non-COPD cohort (61.0 [SD = 15.8] vs 59.9 [SD = 15.8] years) but statistically significant. Compared with non-COPD subjects, COPD patients were more prevalent with comorbidities, including CAD, PAD, asthma, stroke, KD, hypertension, diabetes, hyperlipidemia, depression, and anxiety (all P < 0.001, Table 1). All of medications were more prevalent in the COPD cohort at the baseline (all P < 0.001, Table 1), compared with the non-COPD cohort. After 12 years of follow-up, the cumulative incidence of ED in the COPD cohort was approximately 1.29% higher than that in the non-COPD cohort (P < 0.001, Figure 1).


The risk of erectile dysfunction in chronic obstructive pulmonary disease: a population-based cohort study in Taiwan.

Shen TC, Chen WC, Lin CL, Chen CH, Tu CY, Hsia TC, Shih CM, Hsu WH, Sung FC - Medicine (Baltimore) (2015)

Cumulative incidence of ED in patients with (dashed line) or without (solid line) COPD. COPD = chronic obstructive pulmonary disease, ED = erectile dysfunction.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554043&req=5

Figure 1: Cumulative incidence of ED in patients with (dashed line) or without (solid line) COPD. COPD = chronic obstructive pulmonary disease, ED = erectile dysfunction.
Mentions: Overall, 57,928 subjects were selected for this retrospective cohort study, including 29,042 COPD patients and 28,886 non-COPD controls. The age distribution was similar in both cohorts, with the mean age slightly higher in the COPD cohort than in the non-COPD cohort (61.0 [SD = 15.8] vs 59.9 [SD = 15.8] years) but statistically significant. Compared with non-COPD subjects, COPD patients were more prevalent with comorbidities, including CAD, PAD, asthma, stroke, KD, hypertension, diabetes, hyperlipidemia, depression, and anxiety (all P < 0.001, Table 1). All of medications were more prevalent in the COPD cohort at the baseline (all P < 0.001, Table 1), compared with the non-COPD cohort. After 12 years of follow-up, the cumulative incidence of ED in the COPD cohort was approximately 1.29% higher than that in the non-COPD cohort (P < 0.001, Figure 1).

Bottom Line: Patients were recruited between 2000 and 2011, and the date of diagnosis was defined as the index date.The hazard ratios of ED were estimated using the Cox proportional hazard model after adjusting for age, index year, comorbidities, and medications.Patients with COPD are at a significantly higher risk of developing ED compared with the general population regardless of age and presence of comorbidity.

View Article: PubMed Central - PubMed

Affiliation: From the Graduate Institute of Clinical Medicine Science (T-CS, C-HC, F-CS), College of Medicine; Division of Pulmonary and Critical Care Medicine (T-CS, C-HC, C-YT, T-CH, C-MS, W-HH), Department of Internal Medicine, China Medical University Hospital, Taichung; Division of Pulmonary and Critical Care Medicine (T-CS), Department of Internal Medicine, Chu Shang Show Chwan Hospital, Nantou; Department of Urology (W-CC); Management Office for Health Data (C-LL), China Medical University Hospital, Taichung, Taiwan.

ABSTRACT
The prevalence of erectile dysfunction (ED) in patients with chronic obstructive pulmonary disease (COPD) seemed high; however, large scale of population-based study was absent. We conducted a retrospective cohort study using data from the National Health Insurance system of Taiwan. The cohort included 29,042 male patients who were newly diagnosed with COPD. Patients were recruited between 2000 and 2011, and the date of diagnosis was defined as the index date. Each patient was randomly matched with 1 male person from the general population without COPD according to age and the index year. The occurrence of ED was followed up until the end of 2011. The hazard ratios of ED were estimated using the Cox proportional hazard model after adjusting for age, index year, comorbidities, and medications. The overall incidence of ED was 1.88-fold greater in the COPD cohort than in the non-COPD cohort (24.9 vs 13.3/1000 person-years, 95% confidence interval [CI] = 1.61-2.18). Compared with non-COPD patients, the hazard ratio increased with the number of emergency room visits and admissions for COPD from 1.51 (95% CI 1.29-1.77) to 5.46 (95% CI 3.03-9.84) and from 1.50 (95% CI 1.28-1.76) to 11.5 (95% CI 5.83-22.6), respectively. Patients with COPD are at a significantly higher risk of developing ED compared with the general population regardless of age and presence of comorbidity. The results also support that poor control of COPD status is a key factor affecting ED development.

Show MeSH
Related in: MedlinePlus