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Factors influencing the dosimetry for high-intensity focused ultrasound ablation of uterine fibroids: a retrospective study.

Peng S, Zhang L, Hu L, Chen J, Ju J, Wang X, Zhang R, Wang Z, Chen W - Medicine (Baltimore) (2015)

Bottom Line: The aim of this article is to analyze factors affecting sonication dose and build a dosimetry model of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids.The energy efficiency factor (EEF) was set as dependent variable, and the factors possibly affecting sonication dose included age, body mass index, size of uterine fibroid, abdominal wall thickness, the distance from uterine fibroid dorsal side to sacrum, the distance from uterine fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, abdominal wall scar, signal intensity on T2-weighted imaging (T2WI), and enhancement type on T1-weighted imaging (T1WI) were set as predictors to build a multiple regression model.The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI were eventually incorporated into the dosimetry model.

View Article: PubMed Central - PubMed

Affiliation: From the State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology (SP, LZ, LH, JC, ZW), Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University; HIFU Center for Tumor Therapy (JJ, XW, RZ), 1st Affiliated Hospital of Chongqing Medical University; and Clinical Center for Tumor Therapy (WC), 2nd Affiliated Hospital of Chongqing Medical University, Chongqing, China.

ABSTRACT
The aim of this article is to analyze factors affecting sonication dose and build a dosimetry model of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids. Four hundred and three patients with symptomatic uterine fibroids who underwent HIFU were retrospectively analyzed. The energy efficiency factor (EEF) was set as dependent variable, and the factors possibly affecting sonication dose included age, body mass index, size of uterine fibroid, abdominal wall thickness, the distance from uterine fibroid dorsal side to sacrum, the distance from uterine fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, abdominal wall scar, signal intensity on T2-weighted imaging (T2WI), and enhancement type on T1-weighted imaging (T1WI) were set as predictors to build a multiple regression model. The size of uterine fibroid, distance from fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, signal intensity on T2WI, and enhancement type on T1WI had a linear correlation with EEF. The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI were eventually incorporated into the dosimetry model. The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI can be used as dosimetric predictors for HIFU for uterine fibroids.

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Measurement of distance from uterine fibroid ventral side to skin, uterine fibroid dorsal side to sacrum, and abdominal wall thickness.
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Figure 1: Measurement of distance from uterine fibroid ventral side to skin, uterine fibroid dorsal side to sacrum, and abdominal wall thickness.

Mentions: Data were recorded as follows: locations of uterine fibroids: anterior wall, lateral wall, posterior wall, and with uterine fibroids in fundus recorded as those in the anterior wall; types of uterine fibroids: intramural, submucous, and subserous; uterus locations: anteposition and retroposition; size of fibroids: the maximal diameter in 3 dimensions; distance from fibroid ventral side to skin: the shortest distance from ventral side to skin in T2WI sagittal image of maximal diameter of fibroid (measurement as shown in Fig. 1); distance from fibroid dorsal side to sacrum: the shortest distance from dorsal side to sacrum in T2WI sagittal image of maximal diameter of fibroid (measurement as shown in Fig. 1); abdominal wall thickness: the thickness of skin, subcutaneous fat, rectus abdominis, and peritoneum on inferior border of the second sacral vertebrae according to T2WI sagittal image (measurement as shown in Fig. 1); signal intensity on T2WI; and enhancement type on T1WI.


Factors influencing the dosimetry for high-intensity focused ultrasound ablation of uterine fibroids: a retrospective study.

Peng S, Zhang L, Hu L, Chen J, Ju J, Wang X, Zhang R, Wang Z, Chen W - Medicine (Baltimore) (2015)

Measurement of distance from uterine fibroid ventral side to skin, uterine fibroid dorsal side to sacrum, and abdominal wall thickness.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554030&req=5

Figure 1: Measurement of distance from uterine fibroid ventral side to skin, uterine fibroid dorsal side to sacrum, and abdominal wall thickness.
Mentions: Data were recorded as follows: locations of uterine fibroids: anterior wall, lateral wall, posterior wall, and with uterine fibroids in fundus recorded as those in the anterior wall; types of uterine fibroids: intramural, submucous, and subserous; uterus locations: anteposition and retroposition; size of fibroids: the maximal diameter in 3 dimensions; distance from fibroid ventral side to skin: the shortest distance from ventral side to skin in T2WI sagittal image of maximal diameter of fibroid (measurement as shown in Fig. 1); distance from fibroid dorsal side to sacrum: the shortest distance from dorsal side to sacrum in T2WI sagittal image of maximal diameter of fibroid (measurement as shown in Fig. 1); abdominal wall thickness: the thickness of skin, subcutaneous fat, rectus abdominis, and peritoneum on inferior border of the second sacral vertebrae according to T2WI sagittal image (measurement as shown in Fig. 1); signal intensity on T2WI; and enhancement type on T1WI.

Bottom Line: The aim of this article is to analyze factors affecting sonication dose and build a dosimetry model of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids.The energy efficiency factor (EEF) was set as dependent variable, and the factors possibly affecting sonication dose included age, body mass index, size of uterine fibroid, abdominal wall thickness, the distance from uterine fibroid dorsal side to sacrum, the distance from uterine fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, abdominal wall scar, signal intensity on T2-weighted imaging (T2WI), and enhancement type on T1-weighted imaging (T1WI) were set as predictors to build a multiple regression model.The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI were eventually incorporated into the dosimetry model.

View Article: PubMed Central - PubMed

Affiliation: From the State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology (SP, LZ, LH, JC, ZW), Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University; HIFU Center for Tumor Therapy (JJ, XW, RZ), 1st Affiliated Hospital of Chongqing Medical University; and Clinical Center for Tumor Therapy (WC), 2nd Affiliated Hospital of Chongqing Medical University, Chongqing, China.

ABSTRACT
The aim of this article is to analyze factors affecting sonication dose and build a dosimetry model of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids. Four hundred and three patients with symptomatic uterine fibroids who underwent HIFU were retrospectively analyzed. The energy efficiency factor (EEF) was set as dependent variable, and the factors possibly affecting sonication dose included age, body mass index, size of uterine fibroid, abdominal wall thickness, the distance from uterine fibroid dorsal side to sacrum, the distance from uterine fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, abdominal wall scar, signal intensity on T2-weighted imaging (T2WI), and enhancement type on T1-weighted imaging (T1WI) were set as predictors to build a multiple regression model. The size of uterine fibroid, distance from fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, signal intensity on T2WI, and enhancement type on T1WI had a linear correlation with EEF. The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI were eventually incorporated into the dosimetry model. The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI can be used as dosimetric predictors for HIFU for uterine fibroids.

Show MeSH
Related in: MedlinePlus