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Newly detected pulmonary nontuberculous mycobacterial infection and peripheral lung cancers in patients during follow-up of idiopathic interstitial pneumonia: comparison of CT findings.

Oh SY, Kim MY, Hwang HJ, Shim TS, Choi CM, Kim SS, Kim DS - Medicine (Baltimore) (2015)

Bottom Line: Consolidation (n = 30; 85.7%; odds ratio [OR], 45) and cavities (n = 14; 40%, OR, 25) were more common in NTM-IIP (all P < 0.001).The midst of the fibrotic cysts including honeycomb cysts (n = 16; 45.7%, OR, 4.95) was more common in NTM-IIP (P = 0.006).NTM-IIP appeared larger, with more frequent consolidation and cavities, and was more likely to have been located in the midst of the fibrotic cysts including honeycomb cysts at the CT, which showed that it was older than Cancer-IIP.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Radiology and Research Institute of Radiology (SYO, MYK); Department of Pulmonary and Critical Care Medicine (TSS, C-MC, DSK); Department of Oncology (C-MC), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; and Hallym University College of Medicine (HJH), Hallym University, Sacred Heart Hospital, Anyang, and Department of Healthcare Management (S-SK), Cheongju University, Cheongju, South Korea.

ABSTRACT
This article describes the difference between the computed tomography (CT) findings in patients with newly detected pulmonary nontuberculous mycobacterial infection (NTM-IIP) and Cancer-IIP. We retrospectively evaluated 35 NTM-IIP and 78 Cancer-IIP patients in reference to their idiopathic interstitial pneumonia CT (n = 113), using >10 years of data. Two independent radiologists analyzed the CT characteristics and the axial location of the main opacity. The interobserver agreement was good (κ > 0.771). The NTM-IIP patients were older (P = 0.034). The median size of the main opacity in the NTM-IIP (27 mm; 11-73) was larger (19 mm; 5-60; P = 0.002). Consolidation (n = 30; 85.7%; odds ratio [OR], 45) and cavities (n = 14; 40%, OR, 25) were more common in NTM-IIP (all P < 0.001). The midst of the fibrotic cysts including honeycomb cysts (n = 16; 45.7%, OR, 4.95) was more common in NTM-IIP (P = 0.006). NTM-IIP appeared larger, with more frequent consolidation and cavities, and was more likely to have been located in the midst of the fibrotic cysts including honeycomb cysts at the CT, which showed that it was older than Cancer-IIP.

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Related in: MedlinePlus

Inclusion criteria. (A) Newly detected, incidental pulmonary nontuberculous mycobacterial infection during the CT follow-up of idiopathic interstitial pneumonia. (B) Newly detected, incidental lung cancer found during the CT follow-up of idiopathic interstitial pneumonia. CT = computed tomography, CVD = collagen vascular disease, IPF = idiopathic interstitial fibrosis, NSIP = nonspecific interstitial pneumonia.
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Figure 1: Inclusion criteria. (A) Newly detected, incidental pulmonary nontuberculous mycobacterial infection during the CT follow-up of idiopathic interstitial pneumonia. (B) Newly detected, incidental lung cancer found during the CT follow-up of idiopathic interstitial pneumonia. CT = computed tomography, CVD = collagen vascular disease, IPF = idiopathic interstitial fibrosis, NSIP = nonspecific interstitial pneumonia.

Mentions: For the NTM-IIP group, we reviewed 810 patients in the NTM registry (of T.S.S.) from November 2001 to October 2012 in retrospective manner. The eligibility criteria included the presence of underlying IIPs and incidentally detected NTM with the main opacity such as a nodule, consolidation, or a mass (NTM-IIP) (n = 35) (Figure 1A). All the patients in the NTM-IIP group were diagnosed with NTM pulmonary infection and met the American Thoracic Society/Infectious Diseases Society of America criteria for the diagnosis of NTM infection.11 The confirmation methods of NTM pulmonary infection of the patients are revealed in Table 1.


Newly detected pulmonary nontuberculous mycobacterial infection and peripheral lung cancers in patients during follow-up of idiopathic interstitial pneumonia: comparison of CT findings.

Oh SY, Kim MY, Hwang HJ, Shim TS, Choi CM, Kim SS, Kim DS - Medicine (Baltimore) (2015)

Inclusion criteria. (A) Newly detected, incidental pulmonary nontuberculous mycobacterial infection during the CT follow-up of idiopathic interstitial pneumonia. (B) Newly detected, incidental lung cancer found during the CT follow-up of idiopathic interstitial pneumonia. CT = computed tomography, CVD = collagen vascular disease, IPF = idiopathic interstitial fibrosis, NSIP = nonspecific interstitial pneumonia.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554021&req=5

Figure 1: Inclusion criteria. (A) Newly detected, incidental pulmonary nontuberculous mycobacterial infection during the CT follow-up of idiopathic interstitial pneumonia. (B) Newly detected, incidental lung cancer found during the CT follow-up of idiopathic interstitial pneumonia. CT = computed tomography, CVD = collagen vascular disease, IPF = idiopathic interstitial fibrosis, NSIP = nonspecific interstitial pneumonia.
Mentions: For the NTM-IIP group, we reviewed 810 patients in the NTM registry (of T.S.S.) from November 2001 to October 2012 in retrospective manner. The eligibility criteria included the presence of underlying IIPs and incidentally detected NTM with the main opacity such as a nodule, consolidation, or a mass (NTM-IIP) (n = 35) (Figure 1A). All the patients in the NTM-IIP group were diagnosed with NTM pulmonary infection and met the American Thoracic Society/Infectious Diseases Society of America criteria for the diagnosis of NTM infection.11 The confirmation methods of NTM pulmonary infection of the patients are revealed in Table 1.

Bottom Line: Consolidation (n = 30; 85.7%; odds ratio [OR], 45) and cavities (n = 14; 40%, OR, 25) were more common in NTM-IIP (all P < 0.001).The midst of the fibrotic cysts including honeycomb cysts (n = 16; 45.7%, OR, 4.95) was more common in NTM-IIP (P = 0.006).NTM-IIP appeared larger, with more frequent consolidation and cavities, and was more likely to have been located in the midst of the fibrotic cysts including honeycomb cysts at the CT, which showed that it was older than Cancer-IIP.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Radiology and Research Institute of Radiology (SYO, MYK); Department of Pulmonary and Critical Care Medicine (TSS, C-MC, DSK); Department of Oncology (C-MC), University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; and Hallym University College of Medicine (HJH), Hallym University, Sacred Heart Hospital, Anyang, and Department of Healthcare Management (S-SK), Cheongju University, Cheongju, South Korea.

ABSTRACT
This article describes the difference between the computed tomography (CT) findings in patients with newly detected pulmonary nontuberculous mycobacterial infection (NTM-IIP) and Cancer-IIP. We retrospectively evaluated 35 NTM-IIP and 78 Cancer-IIP patients in reference to their idiopathic interstitial pneumonia CT (n = 113), using >10 years of data. Two independent radiologists analyzed the CT characteristics and the axial location of the main opacity. The interobserver agreement was good (κ > 0.771). The NTM-IIP patients were older (P = 0.034). The median size of the main opacity in the NTM-IIP (27 mm; 11-73) was larger (19 mm; 5-60; P = 0.002). Consolidation (n = 30; 85.7%; odds ratio [OR], 45) and cavities (n = 14; 40%, OR, 25) were more common in NTM-IIP (all P < 0.001). The midst of the fibrotic cysts including honeycomb cysts (n = 16; 45.7%, OR, 4.95) was more common in NTM-IIP (P = 0.006). NTM-IIP appeared larger, with more frequent consolidation and cavities, and was more likely to have been located in the midst of the fibrotic cysts including honeycomb cysts at the CT, which showed that it was older than Cancer-IIP.

Show MeSH
Related in: MedlinePlus