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Retinal nerve fiber layer thickness in myopic, emmetropic, and hyperopic children.

Lee JW, Yau GS, Woo TT, Yick DW, Tam VT, Lai JS - Medicine (Baltimore) (2015)

Bottom Line: A thinner RNFL was associated with an older age (r = -0.4, P < 0.0001), a more myopic spherical equivalent (r = 0.5, P < 0.0001), and a longer axial length (r = -0.4, P < 0.0001) on Pearson correlation analysis.The apparently thicker RNFL in hyperopic and emmetropic children was attributed to their younger age as compared with their myopic counterparts.Advancing age, a more myopic spherical equivalent, and a longer axial length were associated with a thinner RNFL in children.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Ophthalmology (JWYL, GSKY, TTYW, DWFY, VTYT), Caritas Medical Centre; and Department of Ophthalmology (JWYL, JSML), The University of Hong Kong, Hong Kong Special Administrative Region, China.

ABSTRACT
The purpose of this study was to investigate the peripapillary retinal nerve fiber layer (RNFL) thickness in myopic, emmetropic, and hyperopic children using optical coherence tomography. Two-hundred one right eyes of subjects aged 4 to 18 years were divided into 3 groups based on their postcycloplegic spherical equivalent: myopes (<-1.0 D), emmetropes (≥-1.0 to ≤+1.0 D), and hyperopes (>+1.0 D). The RNFL was correlated with age, spherical equivalent, and axial length. The RNFL was compared between the 3 groups before and after age adjustment. The RNFL was thickest in the hyperopic group (107.2 ± 10.13 μm, n = 73), followed by the emmetropic group (102.5 ± 9.2 μm, n = 61), and then the myopic group (95.7 ± 10.3, n = 67) (all P < 0.0001). The myopic group (9.6 ± 3.9 years) was significantly older than the emmetropic (6.9 ± 2.7 years) and hyperopic (6.5 ± 1.9 years) groups (both P < 0.0001). When adjusted for age, myopes had a thinner RNFL than the other 2 groups (all P < 0.0001), but there was no RNFL thickness difference between the emmetropic and hyperopic groups (P > 0.05). A thinner RNFL was associated with an older age (r = -0.4, P < 0.0001), a more myopic spherical equivalent (r = 0.5, P < 0.0001), and a longer axial length (r = -0.4, P < 0.0001) on Pearson correlation analysis. The apparently thicker RNFL in hyperopic and emmetropic children was attributed to their younger age as compared with their myopic counterparts. When adjusted for age, only myopia was associated with a thinner RNFL, with emmetropic and hyperopic children having equal RNFL thicknesses. Advancing age, a more myopic spherical equivalent, and a longer axial length were associated with a thinner RNFL in children.

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Global RNFL thickness with age. RNFL = retinal nerve fiber layer.
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Figure 2: Global RNFL thickness with age. RNFL = retinal nerve fiber layer.


Retinal nerve fiber layer thickness in myopic, emmetropic, and hyperopic children.

Lee JW, Yau GS, Woo TT, Yick DW, Tam VT, Lai JS - Medicine (Baltimore) (2015)

Global RNFL thickness with age. RNFL = retinal nerve fiber layer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4554015&req=5

Figure 2: Global RNFL thickness with age. RNFL = retinal nerve fiber layer.
Bottom Line: A thinner RNFL was associated with an older age (r = -0.4, P < 0.0001), a more myopic spherical equivalent (r = 0.5, P < 0.0001), and a longer axial length (r = -0.4, P < 0.0001) on Pearson correlation analysis.The apparently thicker RNFL in hyperopic and emmetropic children was attributed to their younger age as compared with their myopic counterparts.Advancing age, a more myopic spherical equivalent, and a longer axial length were associated with a thinner RNFL in children.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Ophthalmology (JWYL, GSKY, TTYW, DWFY, VTYT), Caritas Medical Centre; and Department of Ophthalmology (JWYL, JSML), The University of Hong Kong, Hong Kong Special Administrative Region, China.

ABSTRACT
The purpose of this study was to investigate the peripapillary retinal nerve fiber layer (RNFL) thickness in myopic, emmetropic, and hyperopic children using optical coherence tomography. Two-hundred one right eyes of subjects aged 4 to 18 years were divided into 3 groups based on their postcycloplegic spherical equivalent: myopes (<-1.0 D), emmetropes (≥-1.0 to ≤+1.0 D), and hyperopes (>+1.0 D). The RNFL was correlated with age, spherical equivalent, and axial length. The RNFL was compared between the 3 groups before and after age adjustment. The RNFL was thickest in the hyperopic group (107.2 ± 10.13 μm, n = 73), followed by the emmetropic group (102.5 ± 9.2 μm, n = 61), and then the myopic group (95.7 ± 10.3, n = 67) (all P < 0.0001). The myopic group (9.6 ± 3.9 years) was significantly older than the emmetropic (6.9 ± 2.7 years) and hyperopic (6.5 ± 1.9 years) groups (both P < 0.0001). When adjusted for age, myopes had a thinner RNFL than the other 2 groups (all P < 0.0001), but there was no RNFL thickness difference between the emmetropic and hyperopic groups (P > 0.05). A thinner RNFL was associated with an older age (r = -0.4, P < 0.0001), a more myopic spherical equivalent (r = 0.5, P < 0.0001), and a longer axial length (r = -0.4, P < 0.0001) on Pearson correlation analysis. The apparently thicker RNFL in hyperopic and emmetropic children was attributed to their younger age as compared with their myopic counterparts. When adjusted for age, only myopia was associated with a thinner RNFL, with emmetropic and hyperopic children having equal RNFL thicknesses. Advancing age, a more myopic spherical equivalent, and a longer axial length were associated with a thinner RNFL in children.

Show MeSH
Related in: MedlinePlus