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Effect of Momordica charantia fruit extract on vascular complication in type 1 diabetic rats.

Abas R, Othman F, Thent ZC - EXCLI J (2015)

Bottom Line: DM-MC group showed a significant decrease (P < 0.05) in blood pressure, total cholesterol and triglyceride levels compared to the DM-Ctrl group.Aortic tissue NO level was significantly increased and malondialdehyde level was decreased in the DM-MC group.In summary, treatment with the MC fruit extract exerted the significant vasculoprotective effect in the type 1 diabetic rat model.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Malaysia ; Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor.

ABSTRACT
Diabetes mellitus is one of the risk factors in the development of vascular complications. Decreased nitric oxide (NO) production and increased lipid peroxidation in diabetes mellitus are the dominant exaggerating factors. Mormodica charantia (MC) was proven to be useful in improving diabetes mellitus and its complications. In the present study, a total of 40 male Sprague-Dawley rats were used. Diabetes was induced by a single dose (50 mg/kg) of streptozotocin (STZ), intramuscularly. Following 4 weeks of STZ induction, the animals were equally divided into five groups (n = 8); Control group (Ctrl), control group treated with MC (Ctrl-MC), diabetic untreated group (DM-Ctrl), diabetic group treated with MC (DM-MC) and diabetic group treated with metformin 150 g/kg (DM-Met). Oral administration of the MC fruit extract (1.5 g/kg) was continued for 28 days. DM-MC group showed a significant decrease (P < 0.05) in blood pressure, total cholesterol and triglyceride levels compared to the DM-Ctrl group. Aortic tissue NO level was significantly increased and malondialdehyde level was decreased in the DM-MC group. Immunohistochemical staining showed an increase in eNOS expression in the endothelial lining of the DM-MC group. Similarly, morphological deterioration of the aortic tissues was reverted to normal. In summary, treatment with the MC fruit extract exerted the significant vasculoprotective effect in the type 1 diabetic rat model.

No MeSH data available.


Related in: MedlinePlus

Effect of MC fruit extract on the fasting serum lipid profile of Sprague-Dawley rats. *Indicates a significant decrease (P<0.05) in a(TC) and b(TG) levels of the DM-MC group compared to the DM-Ctrl group. # Indicates no significant difference (P>0.05) in c(LDL) and d(HDL) levels.
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Figure 2: Effect of MC fruit extract on the fasting serum lipid profile of Sprague-Dawley rats. *Indicates a significant decrease (P<0.05) in a(TC) and b(TG) levels of the DM-MC group compared to the DM-Ctrl group. # Indicates no significant difference (P>0.05) in c(LDL) and d(HDL) levels.

Mentions: At the end of the pre-treatment period, there was an increase in the fasting serum lipid level in all the experimental diabetic groups. Following 4 weeks of treatment, there was a significant decrease (P < 0.05) TC and TG levels in the DM-MC group (1.42 ± 0.08 mmol/L and 0.57 ± 0.08 mmol/L, respectively) compared to the DM-Ctrl group (2.18 ± 0.19 mmol/L and 0.95 ± 0.09 mmol/L, respectively). Similar findings were observed in DM-Met group. However, no changes were observed with regard to the levels of HDL and LDL in all the groups in the post treatment period (Figure 2(Fig. 2)).


Effect of Momordica charantia fruit extract on vascular complication in type 1 diabetic rats.

Abas R, Othman F, Thent ZC - EXCLI J (2015)

Effect of MC fruit extract on the fasting serum lipid profile of Sprague-Dawley rats. *Indicates a significant decrease (P<0.05) in a(TC) and b(TG) levels of the DM-MC group compared to the DM-Ctrl group. # Indicates no significant difference (P>0.05) in c(LDL) and d(HDL) levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4553902&req=5

Figure 2: Effect of MC fruit extract on the fasting serum lipid profile of Sprague-Dawley rats. *Indicates a significant decrease (P<0.05) in a(TC) and b(TG) levels of the DM-MC group compared to the DM-Ctrl group. # Indicates no significant difference (P>0.05) in c(LDL) and d(HDL) levels.
Mentions: At the end of the pre-treatment period, there was an increase in the fasting serum lipid level in all the experimental diabetic groups. Following 4 weeks of treatment, there was a significant decrease (P < 0.05) TC and TG levels in the DM-MC group (1.42 ± 0.08 mmol/L and 0.57 ± 0.08 mmol/L, respectively) compared to the DM-Ctrl group (2.18 ± 0.19 mmol/L and 0.95 ± 0.09 mmol/L, respectively). Similar findings were observed in DM-Met group. However, no changes were observed with regard to the levels of HDL and LDL in all the groups in the post treatment period (Figure 2(Fig. 2)).

Bottom Line: DM-MC group showed a significant decrease (P < 0.05) in blood pressure, total cholesterol and triglyceride levels compared to the DM-Ctrl group.Aortic tissue NO level was significantly increased and malondialdehyde level was decreased in the DM-MC group.In summary, treatment with the MC fruit extract exerted the significant vasculoprotective effect in the type 1 diabetic rat model.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Malaysia ; Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor.

ABSTRACT
Diabetes mellitus is one of the risk factors in the development of vascular complications. Decreased nitric oxide (NO) production and increased lipid peroxidation in diabetes mellitus are the dominant exaggerating factors. Mormodica charantia (MC) was proven to be useful in improving diabetes mellitus and its complications. In the present study, a total of 40 male Sprague-Dawley rats were used. Diabetes was induced by a single dose (50 mg/kg) of streptozotocin (STZ), intramuscularly. Following 4 weeks of STZ induction, the animals were equally divided into five groups (n = 8); Control group (Ctrl), control group treated with MC (Ctrl-MC), diabetic untreated group (DM-Ctrl), diabetic group treated with MC (DM-MC) and diabetic group treated with metformin 150 g/kg (DM-Met). Oral administration of the MC fruit extract (1.5 g/kg) was continued for 28 days. DM-MC group showed a significant decrease (P < 0.05) in blood pressure, total cholesterol and triglyceride levels compared to the DM-Ctrl group. Aortic tissue NO level was significantly increased and malondialdehyde level was decreased in the DM-MC group. Immunohistochemical staining showed an increase in eNOS expression in the endothelial lining of the DM-MC group. Similarly, morphological deterioration of the aortic tissues was reverted to normal. In summary, treatment with the MC fruit extract exerted the significant vasculoprotective effect in the type 1 diabetic rat model.

No MeSH data available.


Related in: MedlinePlus