Limits...
Sequential development of psoriasis, alopecia universalis, and vitiligo vulgaris in a human immunodeficiency virus seropositive patient: A unique case report.

Gaurkar SP, Parmar KS, Shah BJ - Indian J Sex Transm Dis (2014 Jul-Dec)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, B.J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, We report a Person living with human immunodeficiency virus (HIV)/AIDS developing psoriasis, vitiligo vulgaris, and alopecia universalis in a sequential manner... Although, psoriasis and psoriatic arthritis have been classically associated with HIV, its association with, vitiligo vulgaris and alopecia is rare... Initially, patient had scalp scaling for few months, which was followed by typical annular scaly patches with silvery white scales over back, sacroiliac region, and extensor aspects of limbs... Patient was diagnosed as psoriasis vulgaris in July 2010... In noninfectious manifestations seborrheic dermatitis, psoriasis vulgaris, Reiter's syndrome, xerosis and acquired ichthyosis, papular pruritic eruption of HIV, etc., are seen frequently... Other dermatologic manifestations have been associated primarily with HIV-1 infection... In fact, in patients with known risk for HIV exposure, new onset of psoriasis may sometimes be a marker of HIV infection... Role of infectious agents including viruses have been proposed but not proven... The most consistent histological feature of AA is a perifollicular lymphocytic infiltrate comprised primarily of CD4 + cells associated with a CD8 + intrafollicular infiltrate, as well as a T-helper 1 cytokine profile... Human immunodeficiency virus induced immune dysregulation and altered CD4/CD8 ratio appears to be most plausible explanation for occurrence of AA, vitiligo and psoriasis in HIV... Conditions such as atopic dermatitis, psoriasis, and seborrheic dermatitis, AA, vitiligo are extremely common dermatologic problems expressed in the general population and are seen in HIV seropositive individuals in extensive and unusual forms... However, the direct role of the HIV virus in the pathogenesis of these manifestations is still to be discovered... Better animal models, which may include humanized rodents, might represent a more suitable approach for the study of the pathogenesis of HIV related disorders and the development of more effective forms of treatment.

No MeSH data available.


Related in: MedlinePlus

Vitiligo and alopecia of scalp, eyebrow, beard, moustache region
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4553854&req=5

Figure 2: Vitiligo and alopecia of scalp, eyebrow, beard, moustache region

Mentions: In the month of November 2010 patient developed patches of AA on the temporal scalp which spread rapidly to involve entire scalp, eyebrows, eyelashes, axillary, pubic hair were lost rapidly and within a period of 10 days part landed in alopecia universalis [Figures 2 and 3]. Patient also had trachyonychia or rough nails.


Sequential development of psoriasis, alopecia universalis, and vitiligo vulgaris in a human immunodeficiency virus seropositive patient: A unique case report.

Gaurkar SP, Parmar KS, Shah BJ - Indian J Sex Transm Dis (2014 Jul-Dec)

Vitiligo and alopecia of scalp, eyebrow, beard, moustache region
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4553854&req=5

Figure 2: Vitiligo and alopecia of scalp, eyebrow, beard, moustache region
Mentions: In the month of November 2010 patient developed patches of AA on the temporal scalp which spread rapidly to involve entire scalp, eyebrows, eyelashes, axillary, pubic hair were lost rapidly and within a period of 10 days part landed in alopecia universalis [Figures 2 and 3]. Patient also had trachyonychia or rough nails.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, B.J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, We report a Person living with human immunodeficiency virus (HIV)/AIDS developing psoriasis, vitiligo vulgaris, and alopecia universalis in a sequential manner... Although, psoriasis and psoriatic arthritis have been classically associated with HIV, its association with, vitiligo vulgaris and alopecia is rare... Initially, patient had scalp scaling for few months, which was followed by typical annular scaly patches with silvery white scales over back, sacroiliac region, and extensor aspects of limbs... Patient was diagnosed as psoriasis vulgaris in July 2010... In noninfectious manifestations seborrheic dermatitis, psoriasis vulgaris, Reiter's syndrome, xerosis and acquired ichthyosis, papular pruritic eruption of HIV, etc., are seen frequently... Other dermatologic manifestations have been associated primarily with HIV-1 infection... In fact, in patients with known risk for HIV exposure, new onset of psoriasis may sometimes be a marker of HIV infection... Role of infectious agents including viruses have been proposed but not proven... The most consistent histological feature of AA is a perifollicular lymphocytic infiltrate comprised primarily of CD4 + cells associated with a CD8 + intrafollicular infiltrate, as well as a T-helper 1 cytokine profile... Human immunodeficiency virus induced immune dysregulation and altered CD4/CD8 ratio appears to be most plausible explanation for occurrence of AA, vitiligo and psoriasis in HIV... Conditions such as atopic dermatitis, psoriasis, and seborrheic dermatitis, AA, vitiligo are extremely common dermatologic problems expressed in the general population and are seen in HIV seropositive individuals in extensive and unusual forms... However, the direct role of the HIV virus in the pathogenesis of these manifestations is still to be discovered... Better animal models, which may include humanized rodents, might represent a more suitable approach for the study of the pathogenesis of HIV related disorders and the development of more effective forms of treatment.

No MeSH data available.


Related in: MedlinePlus