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Pyoderma gangrenosum masquerading as Donovanosis.

Pai VV, Kikkeri NN, Athanikar SB, Myageri A, Rai V - Indian J Sex Transm Dis (2014 Jul-Dec)

Bottom Line: PG is diagnosed after excluding more commonly occurring condition presenting with similar manifestation.Though PG has been reported to occur over the genitalia, it rarely presents with concurrent involvement of the groin.Herein, we present a case of PG masquerading as Donovanosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Goa Medical College, Goa, India.

ABSTRACT
Pyoderma gangrenosum (PG) is a rare inflammatory disorder of unknown etiology characterized by neutrophilic infiltration of the dermis and destruction of tissue. PG is diagnosed after excluding more commonly occurring condition presenting with similar manifestation. Though PG has been reported to occur over the genitalia, it rarely presents with concurrent involvement of the groin. Herein, we present a case of PG masquerading as Donovanosis.

No MeSH data available.


Related in: MedlinePlus

Ulcer margin shows irregularly acanthotic epidermis with marked neutrophil exocytosis (H and E, ×10)
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Figure 3: Ulcer margin shows irregularly acanthotic epidermis with marked neutrophil exocytosis (H and E, ×10)

Mentions: Complete hemogram was normal. Biochemical investigations such as random blood sugar liver function tests, and renal function tests were within normal limits. Chest X-ray, venereal disease research laboratory, HBsAg and HIV tests were normal. Dark ground microscopy, ZN stain, Wrights stain of the discharge, and tissue smear was negative. Swab for fungal and bacterial culture did not reveal any growth. Stool for occult blood was negative. Antinuclear antibody, anti-dS DNA, cytoplasmic anti-neutrophil cytoplasmic antibodies, perinuclear anti-neutrophil cytoplasmic antibodies, rheumatoid arthritis factor were negative. Ultrasound abdomen and pelvis did not reveal any abnormalities. Histopathology from the ulcer margin showed irregularly acanthotic and spongiotic epidermis with marked neutrophil exocytosis. Papillary and reticular dermis showed mixed inflammatory infiltrate consisting neutrophils, lymphocytes, and plasma cells. Deeper parts of dermis showed liquefactive necrosis surrounded by neutrophils. Other parts showed dense lymphohistiocytic infiltrate, epithelioid cell granuloma with giant cells and fibrinous exudates. One vessel wall showed neutrophilic infiltrates without fibrinoid necrosis. These features were suggestive of PG [Figures 3 and 4]. Colonoscopy was also normal.


Pyoderma gangrenosum masquerading as Donovanosis.

Pai VV, Kikkeri NN, Athanikar SB, Myageri A, Rai V - Indian J Sex Transm Dis (2014 Jul-Dec)

Ulcer margin shows irregularly acanthotic epidermis with marked neutrophil exocytosis (H and E, ×10)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4553847&req=5

Figure 3: Ulcer margin shows irregularly acanthotic epidermis with marked neutrophil exocytosis (H and E, ×10)
Mentions: Complete hemogram was normal. Biochemical investigations such as random blood sugar liver function tests, and renal function tests were within normal limits. Chest X-ray, venereal disease research laboratory, HBsAg and HIV tests were normal. Dark ground microscopy, ZN stain, Wrights stain of the discharge, and tissue smear was negative. Swab for fungal and bacterial culture did not reveal any growth. Stool for occult blood was negative. Antinuclear antibody, anti-dS DNA, cytoplasmic anti-neutrophil cytoplasmic antibodies, perinuclear anti-neutrophil cytoplasmic antibodies, rheumatoid arthritis factor were negative. Ultrasound abdomen and pelvis did not reveal any abnormalities. Histopathology from the ulcer margin showed irregularly acanthotic and spongiotic epidermis with marked neutrophil exocytosis. Papillary and reticular dermis showed mixed inflammatory infiltrate consisting neutrophils, lymphocytes, and plasma cells. Deeper parts of dermis showed liquefactive necrosis surrounded by neutrophils. Other parts showed dense lymphohistiocytic infiltrate, epithelioid cell granuloma with giant cells and fibrinous exudates. One vessel wall showed neutrophilic infiltrates without fibrinoid necrosis. These features were suggestive of PG [Figures 3 and 4]. Colonoscopy was also normal.

Bottom Line: PG is diagnosed after excluding more commonly occurring condition presenting with similar manifestation.Though PG has been reported to occur over the genitalia, it rarely presents with concurrent involvement of the groin.Herein, we present a case of PG masquerading as Donovanosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Goa Medical College, Goa, India.

ABSTRACT
Pyoderma gangrenosum (PG) is a rare inflammatory disorder of unknown etiology characterized by neutrophilic infiltration of the dermis and destruction of tissue. PG is diagnosed after excluding more commonly occurring condition presenting with similar manifestation. Though PG has been reported to occur over the genitalia, it rarely presents with concurrent involvement of the groin. Herein, we present a case of PG masquerading as Donovanosis.

No MeSH data available.


Related in: MedlinePlus