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Genital donovanosis with malignant transformation: An interesting case report.

Sri KN, Chowdary AS, Reddy BS - Indian J Sex Transm Dis (2014 Jul-Dec)

Bottom Line: It became uncommon due to indiscriminate use of broad spectrum antibiotics.In recent years, much interest is being focused on this condition because genital ulcers facilitate HIV infection.We report an interesting episode of genital donovanosis complicated with squamous cell carcinoma in a middle aged female for its rarity and clinical interest.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Mamata Medical College and Hospital, Khammam, Telangana, India.

ABSTRACT
Donovanosis is a chronic indolent sexually transmitted granulomatous ulceration of genito-inguinal region, caused by Calymmatobacterium granulomatis. It became uncommon due to indiscriminate use of broad spectrum antibiotics. In recent years, much interest is being focused on this condition because genital ulcers facilitate HIV infection. We report an interesting episode of genital donovanosis complicated with squamous cell carcinoma in a middle aged female for its rarity and clinical interest.

No MeSH data available.


Related in: MedlinePlus

Fine-needle aspiration cytology of inguinal lymphnode showing oval cells containing large hyperchromatic nuclei, abundant cytoplasm and high N/C ratio suggestive of squamous cell carcinoma
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Figure 3: Fine-needle aspiration cytology of inguinal lymphnode showing oval cells containing large hyperchromatic nuclei, abundant cytoplasm and high N/C ratio suggestive of squamous cell carcinoma

Mentions: Patient was prescribed capsule doxycycline 100 mg bid for 2 weeks. This did not show any clinical improvement in her condition. Hence, a fine-needle aspiration cytology (FNAC) of the inguinal lymphnode was carried out along with a biopsy from the edge of the ulcer. Both these reports demonstrated features suggestive of squamous cell carcinoma with oval cells containing large hyperchromatic nuclei, abundant cytoplasm, high N/C ratio and keratin pearl formation [Figures 3 and 4]. She was explained about the disease and was referred to MNJ Institute of Oncology Regional Cancer Centre, Hyderabad for further management, where the diagnosis of squamous cell carcinoma was confirmed, and subsequently she has undergone radical vulvectomy with bilateral inguinal lymphnode block dissection [Figure 5].


Genital donovanosis with malignant transformation: An interesting case report.

Sri KN, Chowdary AS, Reddy BS - Indian J Sex Transm Dis (2014 Jul-Dec)

Fine-needle aspiration cytology of inguinal lymphnode showing oval cells containing large hyperchromatic nuclei, abundant cytoplasm and high N/C ratio suggestive of squamous cell carcinoma
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4553842&req=5

Figure 3: Fine-needle aspiration cytology of inguinal lymphnode showing oval cells containing large hyperchromatic nuclei, abundant cytoplasm and high N/C ratio suggestive of squamous cell carcinoma
Mentions: Patient was prescribed capsule doxycycline 100 mg bid for 2 weeks. This did not show any clinical improvement in her condition. Hence, a fine-needle aspiration cytology (FNAC) of the inguinal lymphnode was carried out along with a biopsy from the edge of the ulcer. Both these reports demonstrated features suggestive of squamous cell carcinoma with oval cells containing large hyperchromatic nuclei, abundant cytoplasm, high N/C ratio and keratin pearl formation [Figures 3 and 4]. She was explained about the disease and was referred to MNJ Institute of Oncology Regional Cancer Centre, Hyderabad for further management, where the diagnosis of squamous cell carcinoma was confirmed, and subsequently she has undergone radical vulvectomy with bilateral inguinal lymphnode block dissection [Figure 5].

Bottom Line: It became uncommon due to indiscriminate use of broad spectrum antibiotics.In recent years, much interest is being focused on this condition because genital ulcers facilitate HIV infection.We report an interesting episode of genital donovanosis complicated with squamous cell carcinoma in a middle aged female for its rarity and clinical interest.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Mamata Medical College and Hospital, Khammam, Telangana, India.

ABSTRACT
Donovanosis is a chronic indolent sexually transmitted granulomatous ulceration of genito-inguinal region, caused by Calymmatobacterium granulomatis. It became uncommon due to indiscriminate use of broad spectrum antibiotics. In recent years, much interest is being focused on this condition because genital ulcers facilitate HIV infection. We report an interesting episode of genital donovanosis complicated with squamous cell carcinoma in a middle aged female for its rarity and clinical interest.

No MeSH data available.


Related in: MedlinePlus