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Functional Connections of the Vestibulo-spino-adrenal Axis in the Control of Blood Pressure Via the Vestibulosympathetic Reflex in Conscious Rats.

Lu HJ, Li MH, Li MZ, Park SE, Kim MS, Jin YZ, Park BR - Korean J. Physiol. Pharmacol. (2015)

Bottom Line: Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements.In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohistochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation.These results indicate that the VSA axis may be a key component of the pathway used by the vestibulosympathetic reflex to maintain blood pressure during postural movements.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology and Pathophysiology, Yanbian University College of Medicine and Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules at Yanbian University, Yanji 133002, China.

ABSTRACT
Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohistochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation. Expression of c-Fos protein in the intermediolateral cell column of the middle thoracic spinal regions and blood epinephrine levels were investigated, following microinjection of glutamate receptor agonists or antagonists into the medial vestibular nucleus (MVN) and/or sodium nitroprusside (SNP)-induced hypotension. Both microinjection of glutamate receptor agonists (NMDA and AMPA) into the MVN or rostral ventrolateral medullary nucleus (RVLM) and SNP-induced hypotension led to increased number of c-Fos positive neurons in the intermediolateral cell column of the middle thoracic spinal regions and increased blood epinephrine levels. Pretreatment with microinjection of glutamate receptor antagonists (MK-801 and CNQX) into the MVN or RVLM prevented the increased number of c-Fos positive neurons resulting from SNP-induced hypotension, and reversed the increased blood epinephrine levels. These results indicate that the VSA axis may be a key component of the pathway used by the vestibulosympathetic reflex to maintain blood pressure during postural movements.

No MeSH data available.


Related in: MedlinePlus

The effect of microinjection of glutamate receptor agonists into the MVN on blood pressure. Microinjection of AMPA or NMDA into the MVN increased blood pressure, but blood pressure was not changed following ACSF microinjection. AMPA or NMDA was injected into the right MVN at a concentration of 1.5 mmol/L and a volume of 10 µL. Arrows indicate microinjection of ACSF and glutamate agonists.
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Figure 6: The effect of microinjection of glutamate receptor agonists into the MVN on blood pressure. Microinjection of AMPA or NMDA into the MVN increased blood pressure, but blood pressure was not changed following ACSF microinjection. AMPA or NMDA was injected into the right MVN at a concentration of 1.5 mmol/L and a volume of 10 µL. Arrows indicate microinjection of ACSF and glutamate agonists.

Mentions: The basal range of systolic and diastolic blood pressure was 103~116 mmHg and 72~84 mmHg, respectively, before drug treatment. However, microinjection of glutamate receptor agonists into the MVN increased blood pressure as compared to control levels (Fig. 6).


Functional Connections of the Vestibulo-spino-adrenal Axis in the Control of Blood Pressure Via the Vestibulosympathetic Reflex in Conscious Rats.

Lu HJ, Li MH, Li MZ, Park SE, Kim MS, Jin YZ, Park BR - Korean J. Physiol. Pharmacol. (2015)

The effect of microinjection of glutamate receptor agonists into the MVN on blood pressure. Microinjection of AMPA or NMDA into the MVN increased blood pressure, but blood pressure was not changed following ACSF microinjection. AMPA or NMDA was injected into the right MVN at a concentration of 1.5 mmol/L and a volume of 10 µL. Arrows indicate microinjection of ACSF and glutamate agonists.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4553402&req=5

Figure 6: The effect of microinjection of glutamate receptor agonists into the MVN on blood pressure. Microinjection of AMPA or NMDA into the MVN increased blood pressure, but blood pressure was not changed following ACSF microinjection. AMPA or NMDA was injected into the right MVN at a concentration of 1.5 mmol/L and a volume of 10 µL. Arrows indicate microinjection of ACSF and glutamate agonists.
Mentions: The basal range of systolic and diastolic blood pressure was 103~116 mmHg and 72~84 mmHg, respectively, before drug treatment. However, microinjection of glutamate receptor agonists into the MVN increased blood pressure as compared to control levels (Fig. 6).

Bottom Line: Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements.In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohistochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation.These results indicate that the VSA axis may be a key component of the pathway used by the vestibulosympathetic reflex to maintain blood pressure during postural movements.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology and Pathophysiology, Yanbian University College of Medicine and Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules at Yanbian University, Yanji 133002, China.

ABSTRACT
Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohistochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation. Expression of c-Fos protein in the intermediolateral cell column of the middle thoracic spinal regions and blood epinephrine levels were investigated, following microinjection of glutamate receptor agonists or antagonists into the medial vestibular nucleus (MVN) and/or sodium nitroprusside (SNP)-induced hypotension. Both microinjection of glutamate receptor agonists (NMDA and AMPA) into the MVN or rostral ventrolateral medullary nucleus (RVLM) and SNP-induced hypotension led to increased number of c-Fos positive neurons in the intermediolateral cell column of the middle thoracic spinal regions and increased blood epinephrine levels. Pretreatment with microinjection of glutamate receptor antagonists (MK-801 and CNQX) into the MVN or RVLM prevented the increased number of c-Fos positive neurons resulting from SNP-induced hypotension, and reversed the increased blood epinephrine levels. These results indicate that the VSA axis may be a key component of the pathway used by the vestibulosympathetic reflex to maintain blood pressure during postural movements.

No MeSH data available.


Related in: MedlinePlus